Immunity causing blindness: five different paths to herpes stromal keratitis

Ocular Infection and Immunity

1996 • 425 citations

Acute and Recurrent Infection with Herpes Simplex Virus in the Mouse: a Model for Studying Latency and Recurrent Disease

1975 • 337 citations

Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes.

1995 • 333 citations

Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis.

1992 • 202 citations

IFN-gamma and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice.

1992 • 194 citations

Differential expression of the complement regulatory proteins in the human eye.

1993 • 175 citations

Herpetic keratitis in athymic (nude) mice

1979 • 168 citations

Role of T-lymphocytes in the pathogenesis of herpetic stromal keratitis.

1984 • 166 citations

Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice.

1995 • 139 citations

Contribution of virus and immune factors to herpes simplex virus type I-induced corneal pathology.

1990 • 135 citations

Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas.

1996 • 132 citations

Critical role of corneal Langerhans cells in the CD4- but not CD8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas.

1992 • 130 citations

OCULAR INFECTION AND IMMUNITY

1997 • 128 citations

Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1.

1994 • 123 citations

Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection.

1996 • 118 citations

Resistance to herpes stromal keratitis conferred by an lgG2a-derived peptide

1995 • 111 citations

Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells.

1987 • 107 citations

Herpetic stromal keratitis: an immunopathologic disease mediated by CD4+ T lymphocytes.

1992 • 104 citations

Distinctive humoral immune responses following anterior chamber and intravenous administration of soluble antigen. Evidence for active suppression of IgG2-secreting B lymphocytes.

1990 • 97 citations

Cytokine expression in vivo during murine herpetic stromal keratitis. Effect of protective antibody therapy.

1993 • 94 citations

Herpetic stromal keratitis in the reconstituted scid mouse model

1993 • 94 citations

Phenotypic and functional studies on ocular T cells during herpetic infections of the eye.

1992 • 89 citations

Viral Antigens in the Immune Ring of Herpes Simplex Stromal Keratitis

1980 • 85 citations

Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness).

1995 • 85 citations

T cell cytokine mRNA expression during the course of the immunopathologic ocular disease herpetic stromal keratitis.

1995 • 84 citations

HLA ANTIGENS IN OCULAR TISSUES

1988 • 82 citations

Exacerbation of murine herpes simplex virus-mediated stromal keratitis by Th2 type T cells.

1993 • 72 citations

Immunobiology of Langerhans cells on the ocular surface. I. Langerhans cells within the central cornea interfere with induction of anterior chamber associated immune deviation.

1987 • 70 citations

Intracameral inoculation of herpes simplex virus type I induces anterior chamber associated immune deviation

1982 • 60 citations

Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice.

1989 • 56 citations

Cell-mediated immune tolerance to HSV-1 antigens associated with reduced susceptibility to HSV-1 corneal lesions.

1987 • 48 citations

Genetic studies on murine susceptibility to herpes simplex keratitis

1986 • 47 citations

Alterations in the antigenic structure of two major HSV-1 glycoproteins, gC and gB, influence immune regulation and susceptibility to murine herpes keratitis.

1989 • 44 citations

HLA DR and DQ distribution in normal human ocular structures

1988 • 42 citations

Resolution of HSV corneal infection in the absence of delayed-type hypersensitivity.

1985 • 38 citations

Autoimmunity against corneal antigens. I. Isolation of a soluble 54 Kd corneal epithelium antigen

1986 • 27 citations

Prevention of herpes keratitis by monoclonal antibodies specific for discontinuous and continuous epitopes on glycoprotein D.

1991 • 23 citations

Immunopathology of Herpesvirus Infections

1985 • 21 citations

Superiority of antibody versus delayed hypersensitivity in clearance of HSV-1 from eye.

1987 • 21 citations

Experimental ulcerative herpetic keratitis. I. Systemic immune responses and resistance to corneal infection.

1981 • 20 citations

Passive transfer of anti-HSV-1 IgG protects against stromal keratitis in mice

1988 • 19 citations

INDUCTION OF DELAYED HYPERSENSITIVITY TO ALLOANTIGENS COINJECTED WITH LANGERHANS CELLS INTO THE ANTERIOR CHAMBER OF THE EYE ABROGATION OF ANTERIOR CHAMBER-ASSOCIATED IMMUNE DEVIATION

1989 • 17 citations

Detection of herpes simplex virus induced polypeptides in rabbit trigeminal ganglia.

1984 • 17 citations

Induction of cell-mediated immunity in herpes simplex virus keratitis. Kinetics of lymphocyte transformation and the effect of antiviral antibody.

1980 • 14 citations

Clinical aspects of herpetic eye diseases

1987 • 12 citations

Natural killer cellular cytotoxicity against herpes simplex virus-infected cells in Igh-1-disparate mice.

1990 • 9 citations

The complement components and their inactivators in the intraocular fluids of the guinea pig.

1970 • 7 citations

Protective effects of anti-glycoprotein D monoclonal antibodies in murine herpetic keratitis

1992 • 7 citations

Histological and immunopathological analysis of T-cells mediating murine HSV-1 keratitis

1994 • 7 citations

Cytotoxic T Lymphocyte Activity after Intravitreal Inoculation of Herpes simplex Virus Type I in Mice

1995 • 2 citations