T cell selection and autoimmunity: flexibility and tuning

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Molecular mimicry and autoimmune disease

1987 • 943 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Positive Selection of Thymocytes

1995 • 604 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

T Cell Awareness of Paternal Alloantigens During Pregnancy

1995 • 568 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

T Cell Selection in the Thymus

1988 • 405 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Essential flexibility in the T-cell recognition of antigen

1996 • 330 citations

HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases.

1995 • 301 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses.

1992 • 230 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous Ligands

1995 • 209 citations

Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

1990 • 170 citations

Comparison of peptides bound to spleen and thymus class II.

1993 • 168 citations

T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.

1994 • 162 citations

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1995 • 161 citations

Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunity.

1993 • 149 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

Ligands for the T-cell receptor: hard times for avidity models

1995 • 138 citations

Streptococcal M protein peptide with similarity to myosin induces CD4+ T cell-dependent myocarditis in MRL/++ mice and induces partial tolerance against coxsakieviral myocarditis.

1996 • 102 citations

Similar antigenic surfaces, rather than sequence homology, dictate T-cell epitope molecular mimicry.

1995 • 99 citations

Immunological function of a defined T-cell population tolerized to low-affinity self antigens

1995 • 97 citations

Positive selection of T lymphocytes on fibroblasts

1993 • 92 citations

A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis.

1992 • 85 citations

Recognition of multiple peptide cores by a single T cell receptor.

1995 • 84 citations

Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity.

1993 • 84 citations

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

1994 • 83 citations

Fibroblasts can induce thymocyte positive selection in vivo.

1993 • 73 citations

Crossrecognition by CD8 T cell receptor αβ cytotoxic T lymphocytes of peptides in the self and the mycobacterial hsp60 which share intermediate sequence homology

1995 • 65 citations

Cross-reactive antigen recognition by an encephalitogenic T cell receptor. Implications for T cell biology and autoimmunity.

1992 • 63 citations

Are MHC-bound peptides a nuisance for positive selection?

1994 • 61 citations

Endogenous altered peptide ligands can affect peripheral T cell responses.

1996 • 59 citations

Autologous rat myelin basic protein is a partial agonist that is converted into a full antagonist upon blockade of CD4. Evidence for the integration of efficacious and nonefficacious signals during T cell antigen recognition.

1995 • 55 citations

Mutations in the major histocompatibility complex class I antigen‐presenting groove affect both negative and positive selection of T cells

1990 • 54 citations

Permissive recognition during positive selection

1996 • 52 citations

Frequency of molecular mimicry among T cell peptides as the basis for autoimmune disease and autoantibody induction.

1995 • 51 citations

The influence of invariant chain on the positive selection of single T cell receptor specificities

1995 • 49 citations

TAP1‐deficient mice select a CD8⁺ T cell repertoire that displays both diversity and peptide specificity

1996 • 41 citations

Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection

1993 • 37 citations

Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion

1994 • 33 citations

The T cell receptor as a diverse signal transduction machine.

1996 • 22 citations