Adenovector engineered interleukin-2 expressing autologous plasma cell vaccination after high-dose chemotherapy for multiple myeloma - a phase 1 study

Bone Marrow Transplant

1990 • 2,745 citations

A PROSPECTIVE, RANDOMIZED TRIAL OF AUTOLOGOUS BONE MARROW TRANSPLANTATION AND CHEMOTHERAPY IN MULTIPLE MYELOMA

2013 • 2,176 citations

Experience with the Use of High-Dose Interleukin-2 in the Treatment of 652 Cancer Patients

1989 • 1,003 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

Graft-versus-myeloma effect: proof of principle

1996 • 565 citations

Idiotype Vaccination Using Dendritic Cells After Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma—A Feasibility Study

1999 • 398 citations

Paracrine Cytokine Adjuvants in Cancer Immunotherapy

1995 • 373 citations

Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor

1995 • 269 citations

Graft-versus-myeloma effect in two cases

1996 • 245 citations

Genes encoding tumor-specific antigens are expressed in human myeloma cells

1999 • 201 citations

von Willebrand Factor Propeptide in Vascular Disorders: A Tool to Distinguish Between Acute and Chronic Endothelial Cell Perturbation

1999 • 199 citations

Idiotype Immunization Combined With Granulocyte-Macrophage Colony-Stimulating Factor in Myeloma Patients Induced Type I, Major Histocompatibility Complex–Restricted, CD8- and CD4-Specific T-Cell Responses

1998 • 189 citations

Multicenter phase III trial to evaluate CD34(+) selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma.

1999 • 175 citations

Idiotype Immunization Combined With Granulocyte-Macrophage Colony-Stimulating Factor in Myeloma Patients Induced Type I, Major Histocompatibility Complex–Restricted, CD8- and CD4-Specific T-Cell Responses

1998 • 161 citations

Idiotype Vaccination in Human Myeloma: Generation of Tumor-Specific Immune Responses After High-Dose Chemotherapy

1999 • 150 citations

Gene Transfer as Cancer Therapy

1995 • 142 citations

Idiotypic protein-pulsed adherent peripheral blood mononuclear cell-derived dendritic cells prime immune system in multiple myeloma.

1998 • 133 citations

Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial

1999 • 131 citations

Immunotherapy of Metastatic Malignant Melanoma by a Vaccine Consisting of Autologous Interleukin 2-Transfected Cancer Cells: Outcome of a Phase I Study

1999 • 125 citations

Monoclonal antibody-purged bone marrow transplantation therapy for multiple myeloma

1993 • 108 citations

IL-2 Adenovector-Transduced Autologous Tumor Cells Induce Antitumor Immune Responses in Patients With Neuroblastoma

1998 • 106 citations

IL-2 Adenovector-Transduced Autologous Tumor Cells Induce Antitumor Immune Responses in Patients With Neuroblastoma

1998 • 99 citations

Modulation of anti‐idiotypic immune response by immunization with the autologous M‐component protein in multiple myeloma patients

1996 • 97 citations

Effects of recombinant interleukin-2 administration on cytotoxic function following high-dose chemo-radiotherapy for hematological malignancy

1989 • 93 citations

Bone marrow transplantation in multiple myeloma.

1991 • 87 citations

Gene Therapy with Autologous, Interleukin 2-Secreting Tumor Cells in Patients with Malignant Melanoma

1999 • 79 citations

Malignant plasma cells are sensitive to LAK cell lysis: pre‐clinical and clinical studies of interleukin 2 in the treatment of multiple myeloma

1990 • 33 citations

Induced Expression of B7-1 on Myeloma Cells Following Retroviral Gene Transfer Results in Tumor-Specific Recognition by Cytotoxic T Cells

1999 • 33 citations

Large scale and clinical grade purification of syndecan-1+ malignant plasma cells

1997 • 31 citations

Intensification of the stem cell transplant induction regimen results in increased treatment-related mortality without improved outcome in multiple myeloma

1999 • 29 citations

Efficient adenovirus-mediated gene expression in malignant human plasma cells: relative lymphoid cell resistance.

1998 • 27 citations

Tumor vaccination strategies combined with autologous peripheral stem cell transplantation

1998 • 22 citations

Plasma cell antigens in human multiple myeloma.

1977 • 13 citations

Interleukin-2-Mediated Modulation of Plasma Cell Tumor Growth in a Model of Multiple Myeloma

1998 • 13 citations

Untitled

1998 • 9 citations

Isolation of bone marrow plasma cells by negative selection with immunomagnetic beads

1996 • 3 citations