Idiotype Vaccination in Human Myeloma: Generation of Tumor-Specific Immune Responses After High-Dose Chemotherapy

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

1975 • 3,051 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

A PROSPECTIVE, RANDOMIZED TRIAL OF AUTOLOGOUS BONE MARROW TRANSPLANTATION AND CHEMOTHERAPY IN MULTIPLE MYELOMA

2013 • 2,176 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

Graft-versus-myeloma effect: proof of principle

1996 • 565 citations

T-cell repertoire diversity and clonal expansions in normal and clinical samples

1995 • 562 citations

Induction of Immune Responses in Patients with B-Cell Lymphoma against the Surface-Immunoglobulin Idiotype Expressed by Their Tumors

1992 • 551 citations

Tumor-Specific Idiotype Vaccines in the Treatment of Patients With B-Cell Lymphoma — Long-Term Results of a Clinical Trial

1997 • 464 citations

The Treatment of Multiple Myeloma

1994 • 409 citations

Idiotype Vaccination Using Dendritic Cells After Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma—A Feasibility Study

1999 • 398 citations

Maintenance Treatment with Recombinant Interferon Alfa-2b in Patients with Multiple Myeloma Responding to Conventional Induction Chemotherapy

1990 • 389 citations

Allogeneic bone marrow transplantation versus autologous stem cell transplantation in multiple myeloma: a retrospective case-matched study from the European Group for Blood and Marrow Transplantation

1996 • 376 citations

Toxicity and Efficacy of Defined Doses of CD4+ Donor Lymphocytes for Treatment of Relapse After Allogeneic Bone Marrow Transplant

1998 • 328 citations

Myeloma Proteins as Tumor-Specific Transplantation Antigens

1972 • 325 citations

Donor Leukocyte Infusions Are Effective in Relapsed Multiple Myeloma After Allogeneic Bone Marrow Transplantation

1997 • 315 citations

Expanded CD4+ and CD8+ T cell clones in elderly humans.

1997 • 307 citations

An experimentally validated panel of subfamily‐specific oligonucleotide primers (V_α1‐w29/V_β1‐w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction

1992 • 302 citations

Oligoclonality of tumor-infiltrating lymphocytes from human melanomas.

1994 • 232 citations

Idiotype Immunization Combined With Granulocyte-Macrophage Colony-Stimulating Factor in Myeloma Patients Induced Type I, Major Histocompatibility Complex–Restricted, CD8- and CD4-Specific T-Cell Responses

1998 • 189 citations

The extent of the human germline T-cell receptor V beta gene segment repertoire

1994 • 164 citations

Idiotype Immunization Combined With Granulocyte-Macrophage Colony-Stimulating Factor in Myeloma Patients Induced Type I, Major Histocompatibility Complex–Restricted, CD8- and CD4-Specific T-Cell Responses

1998 • 161 citations

Autotransplants in multiple myeloma: what have we learned?

1996 • 157 citations

High-dose sequential chemoradiotherapy in multiple myeloma: residual tumor cells are detectable in bone marrow and peripheral blood cell harvests and after autografting

1995 • 145 citations

Combination chemotherapy, glucocorticoids, and interferon alfa in the treatment of multiple myeloma: a Southwest Oncology Group study.

1994 • 139 citations

Autologous hapten-modified melanoma vaccine as postsurgical adjuvant treatment after resection of nodal metastases.

1997 • 128 citations

Evidence for a bone marrow B cell transcribing malignant plasma cell VDJ joined to C mu sequence in immunoglobulin (IgG)- and IgA-secreting multiple myelomas.

1993 • 119 citations

Autotransplants in multiple myeloma: what have we learned?

1996 • 118 citations

Idiotype-reactive T-cell subsets and tumor load in monoclonal gammopathies

1995 • 117 citations

Randomized trial of interferon maintenance in multiple myeloma: a study of the National Cancer Institute of Canada Clinical Trials Group.

1995 • 102 citations

A novel nested-PCR strategy for the detection of rearranged immunoglobulin heavy-chain genes in B cell tumors

1997 • 102 citations

Recent Advances in Haematology

1978 • 99 citations

Modulation of anti‐idiotypic immune response by immunization with the autologous M‐component protein in multiple myeloma patients

1996 • 97 citations

DIAGNOSIS, PROGNOSIS, AND STANDARD TREATMENT OF MULTIPLE MYELOMA

1997 • 91 citations

Interferon-alpha for induction and maintenance in multiple myeloma: Results of two multicenter randomized trials and summary of other studies

1995 • 90 citations

A Class I MHC-Restricted Recall Response to a Viral Peptide Is Highly Polyclonal Despite Stringent CDR3 Selection: Implications for Establishing Memory T Cell Repertoires in “Real-World” Conditions

1998 • 87 citations

High-dose sequential chemoradiotherapy, a widely applicable regimen, confers survival benefit to patients with high-risk multiple myeloma.

1994 • 82 citations

Cell-Bound Myeloma Proteins on the Surface of Myeloma Cells: Potential Targets for the Immune System

1972 • 80 citations

A comparison of polychemotherapy and melphalan/prednisone for primary remission induction, and interferon-alpha for maintenance treatment, in multiple myeloma. A prospective trial of the German Myeloma Treatment Group

1995 • 75 citations

Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients

1995 • 75 citations

Mitogens, superantigens, and nominal antigens elicit distinctive patterns of TCRB CDR3 diversity

1996 • 68 citations

Activated idiotype-reactive cells in suppressor/cytotoxic subpopulations of monoclonal gammopathies: correlation with diagnosis and disease status

1988 • 66 citations

Interferon versus interferon plus prednisone remission maintenance therapy for multiple myeloma: a Southwest Oncology Group Study.

1998 • 62 citations

Idiotype‐specific T lymphocytes in monoclonal gammopathies: evidence for the presence of CD4⁺ and CD8⁺ subsets

1997 • 59 citations

Multipin peptide synthesis at the micromole scale using 2‐hydroxyethyl methacryiate grafted polyethylene supports

1993 • 54 citations

Activated idiotype-reactive cells in suppressor/cytotoxic subpopulations of monoclonal gammopathies: correlation with diagnosis and disease status

1988 • 49 citations

Detection of hyperreactive T cells in multiple myeloma by multivalent cross-linking of the CD3/TCR complex [see comments]

1991 • 47 citations

T cells recognize the VH complementarity‐determining region 3 of the idiotypic protein of B cell non‐Hodgkin's lymphoma

1997 • 45 citations

Rapid generation of antiplasma cell activity in the bone marrow of myeloma patients by CD3-activated T cells

1993 • 39 citations

A randomized study of VAD therapy with either concurrent or maintenance interferon in patients with newly diagnosed multiple myeloma

1996 • 35 citations

Immunogenicity and cross‐reactivity with idiotypic IgA of VH CDR3 peptide in multiple myeloma

1998 • 34 citations

Idiotype-induced T cell stimulation requires antigen presentation in association with HLA-DR molecules

1996 • 30 citations

Generation of T cell clones binding F(ab′)2 fragments of the idiotypic immunoglobulin in patients with monoclonal gammopathy

1991 • 28 citations

Multicyclic, dose-intensive chemotherapy supported by hemopoietic progenitors in refractory myeloma patients

1997 • 22 citations

In‐vivo immune responses to idiotypic VH complementarity‐determining region 3 peptide vaccination in B‐cell non‐Hodgkin's lymphoma

1998 • 16 citations

T-cell receptor CDR3 size distribution analysis to evaluate specific T-cell response to cancer vaccines

1997 • 12 citations

The Human T Cell Receptor Repertoire Utilized in Response to HBsAg

1997 • 9 citations

Histoanalytical study of the cellular infiltrate in the tuberculin reaction

1993 • 7 citations