Neoadjuvant Interleukin-12 Immunogene Therapy Protects Against Cancer Recurrence After Liver Resection in an Animal Model

Clinical Score for Predicting Recurrence After Hepatic Resection for Metastatic Colorectal Cancer

1999 • 3,538 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Surgical resection of colorectal carcinoma metastases to the liver: A prognostic scoring system to improve case selection, based on 1568 patients

1996 • 1,658 citations

Resection of colorectal liver metastases

1995 • 1,566 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Hepatic Arterial Infusion of Chemotherapy after Resection of Hepatic Metastases from Colorectal Cancer

1999 • 923 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Prospective Randomized Trial of High-Dose Interleukin-2 Alone or in Conjunction With Lymphokine-Activated Killer Cells for the Treatment of Patients With Advanced Cancer

1993 • 639 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4

1992 • 540 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

Human Mig chemokine: biochemical and functional characterization.

1995 • 378 citations

Randomized Trial of Surgery Versus Surgery Followed by Adjuvant Hepatic Arterial Infusion With 5-Fluorouracil and Folinic Acid for Liver Metastases of Colorectal Cancer

1998 • 357 citations

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

1994 • 335 citations

Interferons in the treatment of human cancer.

1984 • 334 citations

Regulation of human cytolytic lymphocyte responses by interleukin-12

1992 • 331 citations

Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo.

1991 • 315 citations

Interleukin-12

1994 • 285 citations

Hospital Mortality of Major Hepatectomy for Hepatocellular Carcinoma Associated With Cirrhosis

1995 • 280 citations

Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.

1995 • 277 citations

Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells.

1992 • 232 citations

Regression of bladder tumors in mice treated with interleukin 2 gene-modified tumor cells.

1993 • 210 citations

An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.

1990 • 203 citations

Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene.

1992 • 185 citations

Immunotherapy of prostate cancer in the Dunning rat model: use of cytokine gene modified tumor vaccines.

1994 • 181 citations

Therapeutic Efficiency and Safety of a Second-Generation Replication-Conditional HSV1 Vector for Brain Tumor Gene Therapy

1997 • 171 citations

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.

1994 • 167 citations

Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer.

1997 • 150 citations

Surgical treatment of colorectal metastases to the liver

1995 • 135 citations

IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.

1996 • 129 citations

Phase I trial of recombinant interferon gamma in cancer patients.

1986 • 121 citations

Cytokine Gene Therapy of Cancer Using Gene Gun Technology: Superior Antitumor Activity of Interleukin-12

1997 • 118 citations

Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity

1998 • 117 citations

Advanced colorectal cancer is associated with impaired interleukin 12 and enhanced interleukin 10 production.

1998 • 109 citations

Immunotherapy of bladder cancer with cytokine gene-modified tumor vaccines.

1994 • 95 citations

Experimental studies of factors influencing hepatic metastases.II. Effect of partial hepatectomy

1959 • 87 citations

Experimental Studies of Factors Influencing Hepatic Metastases

1962 • 82 citations

Adoptive Immunotherapy for Cancer

1990 • 81 citations

Interleukin 2‐dependent activation of tumor‐specific cytotoxic T lymphocytes in vivo

1991 • 81 citations

A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons

1988 • 78 citations

Interleukin 12 potentiates the curative effect of a vaccine based on interleukin 2-transduced tumor cells.

1996 • 77 citations

Phase I trial of recombinant human gamma-interferon and recombinant human tumor necrosis factor in patients with advanced gastrointestinal cancer.

1989 • 67 citations

Cytokine Gene Therapy or Infusion as Treatment for Solid Human Cancer

1998 • 63 citations

Adjuvant Chemoimmunotherapy for Hepatocellular Carcinoma Patients

1995 • 58 citations

Phase I/II trial of human recombinant beta-interferon serine in patients with renal cell carcinoma.

1986 • 53 citations

Human dendritic cell (DC)-based anti-infective therapy: engineering DCs to secrete functional IFN-gamma and IL-12.

1998 • 52 citations

Rapid Production of Interleukin-2-Secreting Tumor Cells by Herpes Simplex Virus-Mediated Gene Transfer: Implications for Autologous Vaccine Production

1996 • 48 citations

Human Dendritic Cell (DC)-Based Anti-Infective Therapy: Engineering DCs to Secrete Functional IFN-γ and IL-12

1998 • 46 citations

Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon.

1997 • 41 citations

In situ cytokine gene transfection using vaccinia virus vectors.

1996 • 37 citations

Interleukin‐12 Gene Therapy Prevents Establishment of SCC VII Squamous Cell Carcinomas, Inhibits Tumor Growth, and Elicits Long‐term Antitumor Immunity in Syngeneic C3H Mice

1998 • 37 citations

Immunotherapy Via Gene Therapy

1993 • 35 citations

Interferon gamma protects against hepatic tumor growth in rats by increasing Kupffer cell tumoricidal activity

1996 • 35 citations

Rapid and efficient gene transfer in human hepatocytes by herpes viral vectors

1995 • 32 citations

Systemic macrophage activation with liposome-entrapped immunomodulators for therapy of cancer metastasis

1992 • 30 citations

Herpes Simplex Virus (HSV)-Mediated ICAM-1 Gene Transfer Abrogates Tumorigenicity and Induces Anti-Tumor Immunity

1999 • 21 citations

Interleukin-2: Its Biology and Clinical Application in Patients with Cancer

1993 • 20 citations

Impaired interleukin-12 production is associated with a defective anti-tumor response in colorectal cancer

1998 • 19 citations

In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors

1999 • 19 citations

Interleukin-12 Restores Dendritic Cell Function and Cell-Mediated Immunity in Retrovirus-Infected Mice

1998 • 18 citations

Adjuvant immunotherapy using fibroblasts genetically engineered to secrete interleukin 12 prevents recurrence after surgical resection of established tumors in a murine adenocarcinoma model

1999 • 15 citations

Efficient cotransduction of tumors by multiple herpes simplex vectors: Implications for tumor vaccine production

2000 • 15 citations

Easing the Trauma

1990 • 10 citations

The Elogium - L. Pernot: La rhétorique de l̛éloge dans le monde gréco-romain. (Collection des Études Augustiniennes, 137–8.) Vol. 1: Histoire et Technique; Vol. 2: Les Valeurs. Pp. 490; 391. Paris: Institut ďÉtudes Augustiniennes, 1993. Paper.

1995 • 1 citations