An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Molecular Biology of Learning: Modulation of Transmitter Release

1982 • 1,534 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

1986 • 1,118 citations

Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer.

1987 • 881 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

Regulation of Simian Virus 40 Transcription: Sensitive Analysis of the RNA Species Present Early in Infections by Virus or Viral DNA

1979 • 623 citations

Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression

1988 • 508 citations

Progress Toward Human Gene Therapy

1989 • 484 citations

Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells.

1983 • 471 citations

Isolation and Characterization of a Herpes Simplex Virus Type 1 Mutant Containing a Deletion within the Gene Encoding the Immediate Early Polypeptide Vmw110

1986 • 422 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation

1987 • 340 citations

Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1

1986 • 335 citations

[53] Long-term culture of dissociated sympathetic neurons

1979 • 294 citations

Transgenic mice

1985 • 243 citations

The DNA Sequences of the Long Repeat Region and Adjoining Parts of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

1988 • 172 citations

Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs

1987 • 160 citations

Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase.

1990 • 146 citations

A Prominent Serine-rich Region in Vmw175, the Major Transcriptional Regulator Protein of Herpes Simplex Virus Type 1, is not Essential for Virus Growth in Tissue Culture

1990 • 86 citations

A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons

1988 • 78 citations

Determination of the Sequence Alteration in the DNA of the Herpes Simplex Virus Type 1 Temperature-sensitive Mutant ts K

1984 • 75 citations

Biology of gliomas: heterogeneity, oncogenes, growth factors.

1986 • 74 citations

Expression of an immediate early polypeptide and activation of a viral origin of DNA replication in cells containing a fragment of herpes simplex virus DNA

1985 • 61 citations

Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4

1987 • 41 citations

A new method to propagate defective HSV-1 vectors

1988 • 17 citations

Expression of the E. coli Lac Z gene from a defective HSV‐1 vector in various human normal, cancer‐prone and tumor cells

1989 • 17 citations

Morphological and physiological studies on cultured nerve cells from guinea pigs infected with herpes simplex virus in vivo

1983 • 15 citations

Palindrome and palindrome-like sequences of herpes simplex virus DNA

1978 • 7 citations