Rapid Production of Interleukin-2-Secreting Tumor Cells by Herpes Simplex Virus-Mediated Gene Transfer: Implications for Autologous Vaccine Production

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

1993 • 588 citations

Methods for Studying Mononuclear Phagocytes

1981 • 576 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

Expression of bcl-2 From a Defective Herpes Simplex Virus–1 Vector Limits Neuronal Death in Focal Cerebral Ischemia

1995 • 297 citations

Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1

1992 • 296 citations

Antimetastatic vaccination of tumor-bearing mice with two types of IFN-gamma gene-inserted tumor cells.

1993 • 142 citations

Retrovirus-mediated transduction of adult hepatocytes.

1988 • 138 citations

Immunotherapy of bladder cancer with cytokine gene-modified tumor vaccines.

1994 • 95 citations

A Prominent Serine-rich Region in Vmw175, the Major Transcriptional Regulator Protein of Herpes Simplex Virus Type 1, is not Essential for Virus Growth in Tissue Culture

1990 • 86 citations

Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor.

1993 • 85 citations

Retroviral gene transfer induced constitutive expression of interleukin- 2 or interferon-gamma in irradiated human melanoma cells

1992 • 81 citations

Gene Therapy of Cancer: A Pilot Study of IL-4-Gene-Modified Fibroblasts Admixed with Autologous Tumor to Elicit an Immune Response. University of Pittsburgh

1994 • 74 citations

Cationic lipid-mediated transfection of liver cels in primary culture

1992 • 63 citations

Gene delivery to neurons: Is herpes simplex virus the right tool for the job?

1993 • 48 citations

Immunization of Cancer Patients Using Autologous Cancer Cells Modified by Insertion of the Gene for Interleukin-2 (National Institutes of Health)

1992 • 43 citations

Viral Transduction of trkA into Cultured Nodose and Spinal Motor Neurons Conveys NGF Responsiveness

1994 • 37 citations

In vivo adenoviral-mediated human p53 tumor suppressor gene transfer and expression in rat liver after resection.

1994 • 37 citations

A Phase I Trial of Human Gamma Interferon Transduced Autologous Tumor Cells in Patients with Disseminated Malignant Melanoma. Duke University Medical Center, Durham, North Carolina

1994 • 30 citations

Electroporation-mediated gene transfer into hepatocytes: Preservation of a growth hormone response

1992 • 29 citations

Adenoviral-mediated gene transfer into primary human and mouse mammary epithelial cells in vitro and in vivo

1995 • 28 citations

Functional and antigenic properties of cultured T cells in the cell mediated lympholysis (CML) assay

1982 • 23 citations

Generation of Interleukin-2-Secreting Melanoma Cell Populations from Resected Metastatic Tumors

1994 • 22 citations

Effect of Specific Immunotherapy With Preimmunization Against Alpha-Fetoprotein on a Mouse Transplantable Hepatoma: Brief Communication 2

1977 • 19 citations