Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

Stimulus-transcription coupling in neurons: role of cellular immediate-early genes

1989 • 973 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.

1988 • 511 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21^Cip1

1997 • 464 citations

Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

1997 • 462 citations

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1994 • 455 citations

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

1997 • 402 citations

Control of pRB phosphorylation

1998 • 389 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure

1989 • 355 citations

Sequential protein kinase reactions controlling cell growth and differentiation

1994 • 342 citations

Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations.

1991 • 309 citations

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.

1992 • 284 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

1994 • 214 citations

The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.

1995 • 210 citations

Transformation by ras modifies AP1 composition and activity

1997 • 207 citations

Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins.

1992 • 198 citations

Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis

1999 • 186 citations

The Repertoire of Fos and Jun Proteins Expressed during the G₁ Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation

1999 • 179 citations

NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

1995 • 177 citations

Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes.

1994 • 170 citations

Differential activation of p44mapk (ERK1) by α-thrombin and thrombin-receptor peptide agonist

1993 • 163 citations

Transcriptional Activation of the fra-1 Gene by AP-1 Is Mediated by Regulatory Sequences in the First Intron

1995 • 162 citations

Stress-activated kinases regulate protein stability

1998 • 157 citations

Transmembrane Receptors and Intracellular Pathways that Control Cell Proliferation

1992 • 151 citations

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.

1992 • 146 citations

Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product

1997 • 142 citations

Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts

1997 • 139 citations

Regulation of Mitogen-activated Protein Kinase Phosphatase-1 Expression by Extracellular Signal-related Kinase-dependent and Ca2+-dependent Signal Pathways in Rat-1 Cells

1997 • 121 citations

Cell Transformation by c-fos Requires an Extended Period of Expression and Is Independent of the Cell Cycle

1994 • 93 citations

Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells

1996 • 66 citations

Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogenous AP-1

1997 • 59 citations

Ras versus cyclin-dependent kinase inhibitors

1998 • 55 citations

12-O-Tetradecanoyl-Phorbol-13-Acetate Induction of the Human Collagenase Gene Is Mediated By an Inducible Enhancer Element Located in the 5′-Flanking Region

1987 • 47 citations

Expression of Different Jun and Fos Proteins during the G₀-to-G₁ Transition in Mouse Fibroblasts: In Vitro and In Vivo Associations

1991 • 11 citations