A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Electroporation for the efficient transfection of mammalian cells with DNA

1987 • 856 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

1988 • 429 citations

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

1987 • 428 citations

Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor

1988 • 370 citations

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

1988 • 342 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

1990 • 301 citations

Directed Plasminogen Activation at the Surface of Normal and Malignant Cells

1991 • 291 citations

The SV40 enhancer contains two distinct levels of organization

1988 • 286 citations

OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts

1987 • 255 citations

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1988 • 238 citations

The 5′HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites.

1991 • 231 citations

Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA.

1984 • 229 citations

Polyomavirus enhancer contains multiple redundant sequence elements that activate both DNA replication and gene expression.

1985 • 206 citations

PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes.

1989 • 197 citations

Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins.

1988 • 186 citations

Plasminogen activator dependent pathways inthe dissemination of human tumor cells in the chick embryo

1988 • 181 citations

Localization of urokinase-type plasminogen activator in stromal cells in adenocarcinomas of the colon in humans.

1991 • 179 citations

Essential AP-1 and PEA3 binding elements in the human urokinase enhancer display cell type-specific activity.

1991 • 168 citations

Transforming but not immortalizing oncogenes activate the transcription factor PEA1.

1988 • 160 citations

Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester

1990 • 143 citations

Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells.

1990 • 131 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.

1990 • 119 citations

An upstream enhancer and a negative element in the 5' flanking region of the human urokinase plasminogen activator gene

1988 • 112 citations

Induction and desensitization of plasminogen activator gene expression by tumor promoters.

1985 • 103 citations

Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.

1989 • 99 citations

Increase in urokinase plasminogen activator mRNA synthesis in human carcinoma cells is a primary effect of the potent tumor promoter, phorbol myristate acetate.

1986 • 96 citations

lnterleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1

1991 • 89 citations

Positive and negative elements regulate human interleukin 3 expression.

1990 • 87 citations

Urokinase-dependent cell surface proteolysis and cancer.

1990 • 85 citations

Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5′ non-coding sequences that are conserved between mouse and pig

1991 • 53 citations