Patient-Derived Xenograft: An Adjuvant Technology for the Treatment of Metastatic Disease

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

2012 • 7,135 citations

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

2013 • 5,748 citations

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

2011 • 4,808 citations

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

2002 • 4,254 citations

K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer

2008 • 3,476 citations

Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer

2008 • 3,101 citations

The NCI60 human tumour cell line anticancer drug screen

2006 • 2,439 citations

Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer

2011 • 2,267 citations

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

2014 • 1,494 citations

KRAS Mutations As an Independent Prognostic Factor in Patients With Advanced Colorectal Cancer Treated With Cetuximab

2008 • 1,432 citations

Patient-derived tumour xenografts as models for oncology drug development

2012 • 1,197 citations

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

2014 • 1,171 citations

Genome remodelling in a basal-like breast cancer metastasis and xenograft

2010 • 1,138 citations

Phase III Randomized, Intergroup Trial Assessing Imatinib Mesylate At Two Dose Levels in Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing the Kit Receptor Tyrosine Kinase: S0033

2008 • 1,027 citations

Gemcitabine Plusnab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial

2011 • 999 citations

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

2005 • 948 citations

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

2011 • 923 citations

A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

2011 • 876 citations

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

2001 • 830 citations

HETEROTRANSPLANTATION OF A HUMAN MALIGNANT TUMOUR TO “NUDE” MICE

1969 • 700 citations

nab-Paclitaxel Plus Gemcitabine for Metastatic Pancreatic Cancer: Long-Term Survival From a Phase III Trial

2015 • 616 citations

Correlation of Kinase Genotype and Clinical Outcome in the North American Intergroup Phase III Trial of Imatinib Mesylate for Treatment of Advanced Gastrointestinal Stromal Tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group

2008 • 596 citations

Tracking the clonal origin of lethal prostate cancer

2013 • 478 citations

A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models

2013 • 422 citations

Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice

1997 • 400 citations

A New Model of Patient Tumor-Derived Breast Cancer Xenografts for Preclinical Assays

2007 • 392 citations

A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer

2011 • 383 citations

Epidermal Growth Factor Receptor Gene Copy Number and Clinical Outcome of Metastatic Colorectal Cancer Treated With Panitumumab

2007 • 324 citations

Establishment of Patient-Derived Non–Small Cell Lung Cancer Xenografts as Models for the Identification of Predictive Biomarkers

2008 • 276 citations

Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer

2010 • 243 citations

Genomic Changes and Gene Expression Profiles Reveal That Established Glioma Cell Lines Are Poorly Representative of Primary Human Gliomas

2008 • 242 citations

Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development

2004 • 218 citations

Tumor Engraftment in Nude Mice and Enrichment in Stroma- Related Gene Pathways Predict Poor Survival and Resistance to Gemcitabine in Patients with Pancreatic Cancer

2011 • 216 citations

Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review

2010 • 210 citations

Anticancer drug development: the grand challenges

2010 • 207 citations

Metastatic progression of breast cancer: insights from 50 years of autopsies

2013 • 185 citations

Patient-Derived First Generation Xenografts of Non–Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy

2010 • 178 citations

Molecular profiling of patient-derived breast cancer xenografts

2012 • 177 citations

A Validated Tumorgraft Model Reveals Activity of Dovitinib Against Renal Cell Carcinoma

2012 • 174 citations

Advances in the preclinical testing of cancer therapeutic hypotheses

2011 • 150 citations

Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment

2014 • 145 citations

Establishment and Characterization of a Panel of Human Uveal Melanoma Xenografts Derived from Primary and/or Metastatic Tumors

2010 • 145 citations

From Human to Mouse and Back: 'Tumorgraft' Models Surge in Popularity

2008 • 131 citations

Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations

2011 • 121 citations

Current NCI Preclinical Antitumor Screening in Vivo: Results of Tumor Panel Screening, 1976–1982, and Future Directions

1984 • 89 citations

Antitumor Effects and Biomarkers of Activity of AZD0530, a Src Inhibitor, in Pancreatic Cancer

2009 • 86 citations

Prioritizing Phase I Treatment Options Through Preclinical Testing on Personalized Tumorgraft

2011 • 85 citations

Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer

2010 • 70 citations

Growth characteristics and metastatic properties of human breast cancer xenografts in immunodeficient mice.

1998 • 67 citations

Xenografts of primary human gynecological tumors grown under the renal capsule of NOD/SCID mice show genetic stability during serial transplantation and respond to cytotoxic chemotherapy

2008 • 64 citations

Patient-Derived Xenografts from Non–Small Cell Lung Cancer Brain Metastases Are Valuable Translational Platforms for the Development of Personalized Targeted Therapy

2014 • 61 citations

Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer

2014 • 53 citations

Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors

2012 • 42 citations

Tracking sub-clonal TP53 mutated tumor cells in human metastatic renal cell carcinoma

2015 • 28 citations

Clonal intratumor heterogeneity of promoter hypermethylation in breast cancer by MS-MLPA

2013 • 20 citations

Stability of preclinical models of aggressive renal cell carcinomas.

2014 • 8 citations