Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 • 44,461 citations

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

2008 • 8,256 citations

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2005 • 6,083 citations

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

2009 • 5,087 citations

Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence

2007 • 4,498 citations

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

2009 • 3,433 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

2006 • 3,072 citations

Genes that mediate breast cancer metastasis to lung

2005 • 2,834 citations

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

2005 • 2,658 citations

Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma

2004 • 2,644 citations

Molecular determinants of resistance to antiandrogen therapy

2003 • 2,212 citations

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

2010 • 2,023 citations

Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis

2006 • 2,001 citations

The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes

2007 • 1,991 citations

Untitled

2003 • 1,901 citations

Genes that mediate breast cancer metastasis to the brain

2009 • 1,742 citations

Molecular Definition of Breast Tumor Heterogeneity

2007 • 1,338 citations

The molecular portraits of breast tumors are conserved across microarray platforms

2006 • 1,320 citations

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

2006 • 1,296 citations

An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

2005 • 1,279 citations

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

2008 • 1,099 citations

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.

1998 • 1,086 citations

Locoregional Relapse and Distant Metastasis in Conservatively Managed Triple Negative Early-Stage Breast Cancer

2006 • 1,014 citations

An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

2008 • 1,002 citations

The morphologies of breast cancer cell lines in three‐dimensional assays correlate with their profiles of gene expression

2007 • 974 citations

Strong Time Dependence of the 76-Gene Prognostic Signature for Node-Negative Breast Cancer Patients in the TRANSBIG Multicenter Independent Validation Series

2007 • 957 citations

Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

2010 • 941 citations

X chromosomal abnormalities in basal-like human breast cancer

2006 • 838 citations

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

2009 • 825 citations

The Fanconi anaemia/BRCA pathway

2003 • 819 citations

Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

2005 • 794 citations

The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer

2008 • 778 citations

Identification of molecular apocrine breast tumours by microarray analysis

2005 • 727 citations

Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

2010 • 667 citations

Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas

2007 • 605 citations

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

2000 • 565 citations

Differences in breast carcinoma characteristics in newly diagnosed African–American and Caucasian patients

2007 • 556 citations

An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen

2006 • 549 citations

An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer

2007 • 487 citations

Phase II Study of Sunitinib Malate, an Oral Multitargeted Tyrosine Kinase Inhibitor, in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane

2008 • 486 citations

Triple-Negative Breast Cancer: Distinguishing between Basal and Nonbasal Subtypes

2009 • 469 citations

How basal are triple‐negative breast cancers?

2008 • 433 citations

Predictors of Competing Mortality in Advanced Head and Neck Cancer

2009 • 432 citations

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.

2002 • 427 citations

Src signaling in cancer invasion

2010 • 411 citations

Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/“triple-negative” breast cancer cell lines growing in vitro

2007 • 397 citations

Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

2010 • 327 citations

Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin

2008 • 318 citations

Identification of molecular apocrine breast tumours by microarray analysis

2005 • 298 citations

Gene Expression Profiling Shows Medullary Breast Cancer Is a Subgroup of Basal Breast Cancers

2006 • 291 citations

Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors

2009 • 281 citations

Randomized Phase II Study Comparing Two Schedules of Everolimus in Patients With Recurrent/Metastatic Breast Cancer: NCIC Clinical Trials Group IND.163

2009 • 260 citations

Androgen Receptor Expression in Estrogen Receptor-Negative Breast Cancer Immunohistochemical, Clinical, and Prognostic Associations

2003 • 217 citations

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

2008 • 211 citations

Androgen Receptor Levels and Association with PIK3CA Mutations and Prognosis in Breast Cancer

2009 • 198 citations

Androgen Receptor Expression in Estrogen Receptor–Negative Breast Cancer

2003 • 189 citations

Identification of Markers of Taxane Sensitivity Using Proteomic and Genomic Analyses of Breast Tumors from Patients Receiving Neoadjuvant Paclitaxel and Radiation

2010 • 182 citations

A stromal gene signature associated with inflammatory breast cancer

2007 • 170 citations

HER-2 Gene Amplification, HER-2 and Epidermal Growth Factor Receptor mRNA and Protein Expression, and Lapatinib Efficacy in Women with Metastatic Breast Cancer

2008 • 169 citations

Genetic Changes of Wnt Pathway Genes Are Common Events in Metaplastic Carcinomas of the Breast

2008 • 161 citations

Genomic profiling of breast tumours in relation to BRCAabnormalities and phenotypes

2009 • 146 citations

A Precisely Regulated Gene Expression Cassette Potently Modulates Metastasis and Survival in Multiple Solid Cancers

2008 • 142 citations

Functional Roles of Multiple Feedback Loops in Extracellular Signal-Regulated Kinase and Wnt Signaling Pathways That Regulate Epithelial-Mesenchymal Transition

2010 • 141 citations

Genomic instability in breast cancer: Pathogenesis and clinical implications

2010 • 140 citations

Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials

2010 • 129 citations

Phase II trial of the oral PARP inhibitor olaparib (AZD2281) in BRCA-deficient advanced ovarian cancer

2009 • 107 citations

Metaplastic Breast Cancer: Clinical Features and Outcomes

2005 • 99 citations

Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancer

2007 • 82 citations

Neoadjuvant Concurrent Paclitaxel and Radiation in Stage II/III Breast Cancer

2006 • 68 citations

RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells

2010 • 66 citations

Data driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancer

2009 • 56 citations

Phase-II trial of tamoxifen in advanced breast cancer

1979 • 33 citations

Novel Treatment Approaches for Triple-Negative Breast Cancer

2010 • 23 citations

Analysis of estrogen receptor messenger RNA in breast carcinomas from archival specimens is predictive of tumor biology.

1997 • 19 citations

Simultaneous targeting of the androgen receptor and PI3K/mTOR pathway in androgen-dependent and androgen-independent prostate cancer cells.

2010 • 4 citations