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Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

Data up to Jan 2025

Published2005
Citations948
References25

Total Citations Per Year

Abstract

References (25)

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

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Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer

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EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

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RAF/RAS oncogenes and mismatch-repair status

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Systemic Therapy for Colorectal Cancer

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ErbB Receptors: Directing Key Signaling Networks Throughout Life

2004 • 599 citations

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Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer.

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Immunohistochemical Detection of EGFR in Paraffin-embedded Tumor Tissues

2004 • 320 citations

Combined Epidermal Growth Factor Receptor Targeting with the Tyrosine Kinase Inhibitor Gefitinib (ZD1839) and the Monoclonal Antibody Cetuximab (IMC-C225)

2004 • 280 citations

Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs

2003 • 234 citations

Digital karyotyping

2002 • 219 citations

Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers: an immunohistochemical and fluorescent in situ hybridization study

2004 • 181 citations

Prevalence of somatic alterations in the colorectal cancer cell genome

2002 • 179 citations

Therapeutic potential of ABX-EGF: A fully human anti-epidermal growth factor receptor monoclonal antibody for cancer treatment

2002 • 123 citations

ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): An updated analysis

2004 • 86 citations

Epidermal growth factor receptor expression and activation in nonseminomatous germ cell tumors.

2001 • 52 citations

Mutational analysis of gene families in human cancer

2004 • 49 citations

Regulation of epidermal growth factor receptor in human colon cancer cell lines by interferon

2003 • 48 citations

Color multiplex polymerase chain reaction for quantitative analysis of epidermal growth factor receptor genes in colorectal adenocarcinoma

2003 • 32 citations

ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): An updated analysis

2004 • 22 citations

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Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to… (2005) – The Lancet Oncology | Metascience Observatory Explorer