Unique Differentiation Programs of Human Fetal Liver Stem Cells Shown Both In Vitro and In Vivo in NOD/SCID Mice

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.

1995 • 1,223 citations

Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin

1989 • 833 citations

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

1990 • 697 citations

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

The purification and characterization of fetal liver hematopoietic stem cells.

1995 • 607 citations

Cytokine Stimulation of Multilineage Hematopoiesis from Immature Human Cells Engrafted in SCID Mice

1992 • 555 citations

Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic– scid/scid mice

1997 • 495 citations

Ontogeny-related changes in proliferative potential of human hematopoietic cells.

1993 • 413 citations

Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells

1993 • 296 citations

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure.

1982 • 295 citations

Expansionin vitroof adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability

1997 • 276 citations

A developmental switch in B lymphopoiesis.

1991 • 270 citations

Kinetic Evidence of the Regeneration of Multilineage Hematopoiesis From Primitive Cells in Normal Human Bone Marrow Transplanted Into Immunodeficient Mice

1997 • 247 citations

Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero.

1992 • 243 citations

The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts

1996 • 236 citations

Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor

1996 • 234 citations

Hemoglobin F synthesis in vitro: evidence for control at the level of primitive erythroid stem cells.

1977 • 227 citations

The total marrow mass of the mouse: A simplified method of measurement

1984 • 207 citations

Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo

1996 • 163 citations

Relative to adult marrow, fetal liver repopulates nearly five times more effectively long-term than short-term.

1997 • 156 citations

Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep.

1994 • 155 citations

Development of the mouse hematopoietic system

1968 • 152 citations

Developmental switches in the immune system

1994 • 126 citations

Expression of CD33, CD38, and HLA-DR on CD34+ human fetal liver progenitors with a high proliferative potential

1994 • 123 citations

A comparison of long-term repopulating hematopoietic stem cells in fetal liver and adult bone marrow from the mouse.

1996 • 123 citations

Sustained proliferation, multi‐lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood

1997 • 117 citations

Hemoglobins in Development and Differentiation

1982 • 110 citations

Competitive in vivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice

1972 • 106 citations

Ontogeny‐associated changes in the cytokine responses of primitive human haemopoietic cells

1998 • 105 citations

Control of haemoglobin switching by a developmental clock?

1985 • 88 citations

Development of pluripotent hematopoietic progenitor cells in the human fetus

1983 • 84 citations

Impaired Steel Factor Responsiveness Differentially Affects the Detection and Long-Term Maintenance of Fetal Liver Hematopoietic Stem Cells In Vivo

1997 • 79 citations

Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line

1992 • 77 citations

Macrophages are the first differentiated blood cells formed in human embryonic liver.

1980 • 69 citations

Candidate hematopoietic stem cells from fetal tissues, umbilical cord blood vs. adult bone marrow and mobilized peripheral blood.

1998 • 67 citations

CD34++ CD38- and CD34+ CD38+ human hematopoietic progenitors from fetal liver, cord blood, and adult bone marrow respond differently to hematopoietic cytokines depending on the ontogenic source.

1998 • 65 citations

Human embryonic hemopoiesis: Control mechanisms underlying progenitor differentiation in vitro

1988 • 63 citations

HbF and HbA production in erythroid cultures from human fetuses and neonates

1979 • 62 citations

Identification and characterization of three classes of erythroid progenitors in human fetal liver

1981 • 59 citations

Quantitation and characterization of human megakaryocyte colony‐forming cells using a standardized serum‐free agarose assay

1997 • 58 citations

Erythroid colony formation from human fetal liver.

1978 • 52 citations

ANALYSIS OF PROLIFERATION AND DIFFERENTIATION OF FOETAL GRANULOCYTE‐MACROPHAGE PROGENITOR CELLS IN HAEMOPOIETIC TISSUE*

1973 • 52 citations

Expression of CD34 on human B cell precursors

1991 • 49 citations

Phenotypic and functional characterization of committed and primitive myeloid and lymphoid hematopoietic precursors in human fetal liver.

1997 • 43 citations

In Vitro Culture of Erythroid Colonies from Human Fetal Liver and Umbilical Cord Blood*

1979 • 35 citations

Sheep fetal haematopoietic cells produce adult haemoglobin when transplanted in the adult animal

1979 • 35 citations

Successful reconstitution of human hematopoiesis in the SCID-hu mouse by genetically modified, highly enriched progenitors isolated from fetal liver.

1997 • 34 citations

Transplantation of hemopoietic cells from the fetal liver to treat patients with congenital diseases postnatally or prenatally

1997 • 32 citations

Simultaneous assessment of i-antigenic expression and fetal hemoglobin in single red cells by immunofluorescence

1980 • 31 citations

The ontogeny of erythropoiesis in the mouse detected by the erythroid colony-forming technique. II. Transition in erythropoietin sensitivity during development.

1980 • 31 citations

Erythroid colony formation (CFUe) in fetal liver and adult bone marrow and spleen from the mouse

1976 • 29 citations

Severe Combined Immunodeficiency Mice Engrafted With Human T Cells, B Cells, and Myeloid Cells After Transplantation With Human Fetal Bone Marrow or Liver Cells and Implanted With Human Fetal Thymus: A Model for Studying Human Gene Therapy

1997 • 27 citations

Stem cell factor induces proliferation and differentiation of fetal progenitor cells in the mouse

1998 • 26 citations

Effect of burst-promoting activity (BPA) and erythropoietin on hemoglobin biosynthesis in culture

1980 • 26 citations

Successful Reconstitution of Human Hematopoiesis in the SCID-hu Mouse by Genetically Modified, Highly Enriched Progenitors Isolated From Fetal Liver

1997 • 25 citations

The ontogeny of erythropoiesis in the mouse detected by the erythroid colony-forming technique: II. Transition in erythropoietin sensitivity during development

1980 • 25 citations

Culture of Purified Stem Cells from Fetal Liver Results in Loss of In Vivo Repopulating Potential

1996 • 25 citations

Fetal to adult hemopoietic cell transplantation in humans: insights into hemoglobin switching

1986 • 18 citations

The Pattern of Stem Cell Repopulation in Heavily Irradiated Mice Receiving Transplants of Fetal Liver

1970 • 16 citations

Effect of burst-promoting activity (BPA) and erythropoietin on hemoglobin biosynthesis in culture

1980 • 15 citations

Fetal haemoglobin synthesis following fetal liver transplantation in man

1983 • 10 citations