Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

1990 • 697 citations

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

1995 • 606 citations

Clonal and systemic analysis of long-term hematopoiesis in the mouse.

1990 • 577 citations

Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.

1990 • 456 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies.

1981 • 386 citations

Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function

1995 • 340 citations

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure.

1982 • 295 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations.

1993 • 288 citations

Decline in colony‐forming ability of marrow cells subjected to serial transplantation into irradiated mice

1964 • 276 citations

The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts

1996 • 236 citations

Life span of multipotential hematopoietic stem cells in vivo.

1990 • 228 citations

Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging.

1978 • 224 citations

Proliferative capacity of murine hematopoietic stem cells.

1978 • 156 citations

Evidence for structured variation in self-renewal capacity within long-term bone marrow cultures.

1980 • 153 citations

Self-renewal of hemopoietic stem cells during mixed colony formation in vitro.

1981 • 153 citations

The Efficient Design of Transplantable Tumour Assays

1963 • 147 citations

Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability.

1992 • 144 citations

Amplification of Sca-1+ Lin-WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential

1994 • 139 citations

Serial depletion and regeneration of the murine hematopoietic system. Implications for hematopoietic organization and the study of cellular aging

1982 • 137 citations

Effects of transplantation on the primitive immunohematopoietic stem cell.

1990 • 136 citations

A comparison of long-term repopulating hematopoietic stem cells in fetal liver and adult bone marrow from the mouse.

1996 • 123 citations

Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer

1994 • 108 citations

Competitive in vivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice

1972 • 106 citations

Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability

1989 • 100 citations

Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells

1990 • 100 citations

A COMPARATIVE STUDY OF THE REPOPULATING POTENTIAL OF GRAFTS FROM VARIOUS HAEMOPOIETIC SOURCES: CFU REPOPULATION

1970 • 68 citations

Normal Function of Transplanted Mouse Erythrocyte Precursors for 21 Months beyond Donor Life Spans

1972 • 52 citations

Granulocyte-macrophage colony-stimulating factor modulation of the inhibitory effect of transforming growth factor-beta on normal and leukemic human hematopoietic progenitor cells.

1992 • 39 citations

Role of Transforming Growth Factor‐β1 in Regulation of Hematopoiesis^ab

1991 • 29 citations

Transforming growth factor β and interleukin-1: a paradigm for opposing regulation of haemopoiesis

1992 • 28 citations

Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability

1989 • 10 citations

Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer

1994 • 7 citations

Self‐renewal and differentiation capacity of bone marrow and fetal liver stem cells

1982 • 6 citations

Amplification of Sca-1+ Lin-WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential

1994 • 4 citations

Decline in colony-forming ability of marrow cells subjected to serial transplantation into irradiated mice

1965 • 2 citations