Adenosine receptors in the central nervous system: Relationship to the central actions of methylxanthines

Adenosine 3‘,5‘-Phosphate in Biological Materials

1962 • 2,102 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.

1970 • 860 citations

Cyclic Nucleotide-dependent Protein Kinases

1969 • 551 citations

Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity.

1970 • 462 citations

The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat

1972 • 366 citations

ADENINE NUCLEOTIDES AND SYNAPTIC TRANSMISSION IN THE in vitro RAT HIPPOCAMPUS

1980 • 357 citations

Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex

1979 • 338 citations

Effects of Adenosine Nucleosides on Adenylate Cyclase, Phosphodiesterase, Cyclic Adenosine Monophosphate Accumulation, and Lipolysis in Fat Cells

1972 • 321 citations

Alkylxanthines: Inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity

1979 • 311 citations

Cyclic Nucleotides in the Nervous System

1977 • 297 citations

Adenosine inhibits the accumulation of cyclic AMP in cultured brain cells

1978 • 251 citations

Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides

1979 • 222 citations

Release of norepinephrine in the central nervous system by theophylline and caffeine

1970 • 210 citations

Cyclic Adenosine Monophosphate Phosphodiesterase in Brain: Effect on Anxiety

1972 • 207 citations

Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists

1980 • 198 citations

Purinergic inhibition of diazepam binding to rat brain ()

1979 • 195 citations

Multiple cyclic nucleotide phosphodiesterase activities from rat tissues and occurrence of a calcium-plus-magnesium-ion-dependent phosphodiesterase and its protein activator

1975 • 170 citations

Protective effect of adenosine and nicotinamide against audiogenic seizure

1974 • 170 citations

ADENOSINE INHIBITION OF γ‐AMINOBUTYRIC ACID RELEASE FROM SLICES OF RAT CEREBRAL CORTEX

1980 • 163 citations

Rhythmic hyperpolarizations and depolarization of sympathetic ganglion cells induced by caffeine

1976 • 159 citations

Adenosine modulation of synaptosomal dopamine release

1979 • 158 citations

Inhibition of slow action potentials of guinea pig atrial muscle by adenosine: A possible effect on Ca2+ influx

1975 • 157 citations

Preliminary data on the possible hypnogenic role of adenosine¹

1973 • 157 citations

Adenosine modulates depolarization-induced release of 3H-noradrenaline from slices of rat brain neocortex

1978 • 154 citations

Adenosine-elicited accumulation of cyclic AMP in brain slices: Potentiation by agents which inhibit uptake of adenosine

1974 • 153 citations

Adenosine-dependent formation of cyclic AMP in brain slices

1976 • 149 citations

Presynaptic inhibitory actions of adenine nucleotides and adenosine on neurotransmission in the rat vas deferens

1977 • 145 citations

Physiological and regulatory functions of adenosine and adenine nucleotides

1979 • 144 citations

Effects of catecholamines and adenosine derivatives given into the brain of fowls

1972 • 136 citations

Regulation of cyclic adenosine 3',5'-monophosphate levels in guinea-pig cerebral cortex by interaction of alpha adrenergic and adenosine receptor activity.

1975 • 126 citations

INCREASE IN THE CONTENT OF ADENOSINE 3′5′‐ MONOPHOSPHATE IN MOUSE FOREBRAIN DURING SEIZURES AND PREVENTION OF THE INCREASE BY METHYLXANTHINES

1971 • 126 citations

Fluoronorepinephrines: specific agonists for the activation of alpha and beta adrenergic-sensitive cyclic AMP-generating systems in brain slices.

1980 • 125 citations

Adenosine and adenosine triphosphate decrease 45Ca uptake by synaptosomes stimulated by potassium

1979 • 124 citations

DEPRESSION OF EVOKED POTENTIALS IN BRAIN SLICES BY ADENOSINE COMPOUNDS

1978 • 124 citations

Purinergic depression of neurons in different areas of the rat brain

1977 • 123 citations

Restless legs, anxiety and caffeinism.

1978 • 119 citations

Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP

1979 • 119 citations

Cyclic adenosine monophosphate antagonism of morphine analgesia.

1973 • 119 citations

Antagonistic effects of theophylline and adenosine on adrenergic neuroeffector transmission in the rabbit kidney.

1978 • 116 citations

Purinergic inhibition of adrenergic transmission in rabbit blood vessels.

1978 • 107 citations

The dextro and levorotatory isomers of N-phenylisopropyladenosine: Stereospecific effects on cyclic AMP-formation and evoked synaptic responses in brain slices

1979 • 106 citations

Inhibitory effect of adenosine on adrenergic neuroeffector transmission in the rabbit heart

1979 • 106 citations

Possible feed-back inhibition of noradrenaline release by purine compounds

1977 • 104 citations

Some effects of caffeine and aminophylline on the turnover of catecholamines in the brain

1971 • 102 citations

A Cyclic Adenosine Monophosphate Link in the Catecholamine Enhancement of Transmitter Release at the Neuromuscular Junction

1974 • 100 citations

Effects of caffeine on central monoamine neurons

1972 • 98 citations

Mouse neuroblastoma adenylate cyclase. Adenosine and adenosine analogues as potent effectors of adenylate cyclase activity.

1975 • 98 citations

Effect of some phosphodiesterase inhibitors on central dopamine mechanisms

1976 • 95 citations

Accumulations of Cyclic AMP in Adenine‐Labeled Cell‐free Preparations from Guinea Pig Cerebral Cortex: Role of α‐Adrenergic and H₁‐Histaminergic Receptors

1980 • 93 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1981 • 91 citations

Incorporation of nucleosides into the nucleotide pools of human erythrocytes. Adenosine and its analogs

1973 • 89 citations

Effect of theophylline and other drugs on rabbit renal cyclic nucleotide phosphodiesterase, 5′-nucleotidase and adenosine deaminase

1978 • 88 citations

The effect of caffeine and theophylline on the disposition of brain serotonin in the rat

1971 • 80 citations

Effects of adenosine derivatives on cAMP accumulation and lipolysis in rat adipocytes and on adenylate cyclase in adipocyte plasma membranes

1977 • 70 citations

Specific binding of 2-[³H]chloroadenosine to rat brain cortical membranes

1980 • 69 citations

The role of calcium ions in accumulation of cyclic adenosine monophosphate elicited by alpha and beta adrenergic agonists in rat brain slices.

1977 • 69 citations

KINETICS OF ADENOSINE UPTAKE INTO ASTROCYTES

1978 • 68 citations

Presynaptic inhibitory actions of 2-substituted adenosine derivatives on neurotransmission in rat vas deferens: Effects of inhibitors of adenosine uptake and deamination

1979 • 67 citations

Regulation of adenosine cyclic 3',5'-phosphate formation in cerebral cortical slices. Interaction among norepinephrine, histamine, serotonin.

1971 • 61 citations

Characterization of [3H]adenosine binding to fat cell membranes.

1978 • 60 citations

Specific binding of 3H-adenosine to rat brain membranes

1979 • 57 citations

Inhibitory action of adenosine and adenosine analogs on neutrotransmission in the olfactory cortex slice of guinea pig — Structure-activity relationships

1980 • 57 citations

RELATED CHANGES IN AMOUNTS OF ACh AND ATP IN RESTING AND ACTIVE TORPEDO NERVE ELECTROPLAQUE SYNAPSES

1977 • 56 citations

Studies on adenosine deaminase. I. Purification and properties of ox heart adenosine deaminase.

1966 • 55 citations

Elevation of cyclic amp in C-1300 murine neuroblastoma by adenosine and related compounds and the antagonism of this response by methylxanthines

1977 • 52 citations

Inhibition of brain adenosine deaminase by 2′‐deoxycoformy cin and erythro‐9‐(2‐hydroxy‐3‐nonyl) adenine

1978 • 52 citations

Inhibition of adenosine uptake in human erythrocytes by adenosine-5'-carboxamides, xylosyladenine, dipyridamole, hexobendine, and p-nitrobenzylthioguanosine

1978 • 52 citations

Inhibitory action of adenosine, 5-HT (serotonin) and GABA (γ-aminobutyric acid) on the postsynaptic potential (PSP) of slices from olfactory cortex and superior colliculus in correlation to the level of cyclic AMP

1979 • 49 citations

Is adenosine the mediator of opiate action on neuronal firing rate?

1979 • 48 citations

Parallel investigations of the effects of adenosine on evoked potentials and cyclic AMP accumulation in hippocampus slices of the rat

1979 • 47 citations

BLOCKADE OF STRIATAL NEURONE RESPONSES TO MORPHINE BY AMINOPHYLLINE: EVIDENCE FOR ADENOSINE MEDIATION OF OPIATE ACTION

1980 • 45 citations

INHIBITION OF 5′‐NUCLEOTIDASE IN RAT BRAIN BY METHYLXANTHINES

1975 • 45 citations

8-Substituted theophyllines. In vitro inhibition of 3',5'-cyclic adenosine monophosphate phosphodiesterase and pharmacological spectrum in mice

1971 • 44 citations

The action of adenosine on noradrenergic neuronal inhibition induced by stimulation of locus coeruleus

1980 • 41 citations

The accumulation of cyclic AMP and cyclic GMP in guinea pig brain slices

1977 • 40 citations

Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium

1978 • 40 citations

The actions of adenosine and various nucleosides and nucleotides on the isolated toad spinal cord

1978 • 37 citations

An electrophysiological demonstration of a synergistic interaction between norepinephrine and adenosine in the cerebral cortex

1978 • 36 citations

Saturable binding of adenosine to the dog heart microsomal fraction: competitive inhibition by aminophylline.

1979 • 34 citations

Protein phosphorylation: The nature, function, and metabolism of proteins which contain covalently bound phosphorus

1979 • 33 citations

Structure activity relations for inhibition of neurotransmission in rat vas deferens by adenosine

1978 • 30 citations

Uptake and release of adenosine by cultured astrocytoma cells

1979 • 30 citations

Pharmacologic and behavioral effects of EMD 28422: A novel purine which enhances (3H) diazepam binding to brain benzodiazepine receptors

1980 • 30 citations

Diazepam and flurazepam inhibit adenosine uptake by rat brain synaptosomes

1980 • 29 citations

Caffeine effects on transmitter depletion and mobilization at motor nerve terminals

1969 • 27 citations

High affinity binding of 2-chloroadenosine to rat brain synaptic membranes

1980 • 27 citations

Cyclic Nucleotides in the Nervous System

1978 • 26 citations

Antidepressant drugs potentiate suppression by adenosine of neuronal firing in rat cerebral cortex

1979 • 23 citations

Adenosine transport by a variant of C1300 murine neuroblastoma cells deficient in adenosine kinase

1980 • 22 citations

INHIBITORY EFFECT OF ADENOSINE AND ADENINE NUCLEOTIDES ON POTASSIUM‐EVOKED EFFLUX OF [³H]‐NORADRENALINE FROM THE RAT ISOLATED HEART: LACK OF RELATIONSHIP TO PROSTAGLANDINS

1980 • 22 citations

Inhibition of alkaline phosphatase by substituted xanthines

1979 • 21 citations

The influence of caffeine and theobromine on locomotive activity and the brain cGMP/cAMP ratio in white mice

1977 • 20 citations

Adenosine-binding to cerebral preparations in interpretation of adenosine activation of adenosine 3′:5′-cyclic monophosphate formation

1980 • 19 citations

Elevation of guanosine 3′,5′-monophosphate level by adenosine in cerebellar slices of guinea pig

1977 • 19 citations

Cyclic nucleotide concentrations in the brains of mice treated with the convulsant bicyclic organophosphate, 4-isopropyl-2,6,7-trioxa-1 -phosphabicyclo[2,2,2] octane

1979 • 18 citations

An Adenosine 3′:5′‐Monophosphate/Adenosine Binding Protein from Mouse Liver

1978 • 18 citations

1-Isoamyl-3-isobutylxanthine: A remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic AMP in brain slices

1979 • 18 citations

Effects of adenosine on neurally mediated norepinephrine release from the cat spleen

1979 • 17 citations

Potentiation by homocysteine of adenosine-stimulated elevation of cellular adenosine 3′,5′-monophosphate

1979 • 14 citations

Single-dose tolerance to the behavioral effects of dibutyryl cyclic AMP in mice

1977 • 13 citations

Adenosine and related compounds do not affect nerve terminal excitability in rat CNS

1980 • 13 citations

The Synthesis and Pharmacologic Evaluation of a Series of 8-Alkylthio-Thiated Theophyllines¹

1966 • 12 citations

Presynaptic inhibition of neurotransmission in rat vas deferens by 2-(p-methoxyphenyl) adenosine, ethyl adenosine-5′-carboxylate and N-cy clopropyl adenosine-5′-carboxamide

1980 • 11 citations

Brain benzodiazepine levels following intravenous administration of [³H]diazepam: Relationship to the potentiation of purinergic depression of central nervous system neurons

1979 • 9 citations

Inhibitory effect of 8-substituted adenosine derivatives on Ca++ and modulator protein-dependent phosphodiesterase activity

1978 • 9 citations

Isolation of a cyclic AMP‐adenosine binding protein from rat heart

1979 • 4 citations

The hypnotic properties of 8-ethylthio-6-thiotheophylline sodium

1968 • 3 citations