Human breast cancer: prognostic significance of the c-erbB-2 oncoprotein compared with epidermal growth factor receptor, DNA ploidy, and conventional pathologic features.

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry.

1983 • 2,066 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

A Detergent‐trypsin method for the preparation of nuclei for flow cytometric DNA analysis

1983 • 1,681 citations

A Comparative Study of the Peroxidase-antiperoxidase Method and an Avidin-Biotin Complex Method for Studying Polypeptide Hormones with Radioimmunoassay Antibodies

1981 • 1,664 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

The Product of the Human c- erb B-2 Gene: a 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity

1986 • 805 citations

The pathology of invasive breast cancerA Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)

1975 • 755 citations

Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer.

1990 • 602 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

Prediction of Relapse or Survival in Patients with Node-Negative Breast Cancer by DNA Flow Cytometry

1989 • 571 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

HER-2/neu amplification predicts poor survival in node-positive breast cancer.

1990 • 456 citations

OVEREXPRESSION OF THE c-erbB-2 ONCOPROTEIN IN HUMAN BREAST CARCINOMAS: IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION

1987 • 409 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

A monoclonal antibody to the human epidermal growth factor receptor

1982 • 342 citations

p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.

1986 • 341 citations

Log-Logistic Regression Models for Survival Data

1983 • 333 citations

Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.

1989 • 321 citations

DNA flow cytometry and prognostic factors in 1331 frozen breast cancer specimens

1988 • 301 citations

Amplification of c- erb B-2 and Aggressive Human Breast Tumors?

1988 • 240 citations

Epidermal growth factor stimulation of human breast cancer cells in culture.

1980 • 223 citations

Presence of transforming growth factors in human breast cancer cells.

1984 • 222 citations

An immunohistochemical evaluation of c-erbB-2 expression in human breast carcinoma

1988 • 206 citations

Expression of the c‐erbB‐2 protein in normal and transformed cells

1987 • 197 citations

Cell kinetics as a prognostic marker in node-negative breast cancer

1985 • 197 citations

A Course in Theortical Statistics.

1970 • 159 citations

Regression Models and Non-Proportional Hazards in the Analysis of Breast Cancer Survival

1984 • 145 citations

Autocrine and paracrine growth regulation of human breast cancer

1986 • 135 citations

c-erbB-2 amplification in node-negative human breast cancer.

1989 • 117 citations

Relationship between epidermal growth factor receptor status and various prognostic factors in human breast cancer

1990 • 100 citations

Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells.

1986 • 98 citations

Tumor promoter and epidermal growth factor stimulate phosphorylation of the c-erbB-2 gene product in MKN-7 human adenocarcinoma cells.

1988 • 80 citations

Heterogeneous expression of erbB-2 messenger RNA in human breast cancer.

1989 • 62 citations

Human breast cancer: identification of populations with a high risk of early relapse in relation to both oestrogen receptor status and c-erbB-2 overexpression

1990 • 56 citations

Amplification of c- erb B-2 and Aggressive Human Breast Tumors?

1988 • 51 citations

Immunocytochemical Determination of Epidermal Growth Factor Receptor with Monoclonal EGFR1 Antibody in Primary Breast Cancer Patients

1990 • 23 citations

The role of the pathologist in breast cancer management

1990 • 20 citations

Oncogene structure, function, and expression in breast cancer.

1989 • 11 citations