Tumour suppressor gene products, proliferation, and differentiation markers in lung neuroendocrine neoplasms

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

1984 • 4,180 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms

1990 • 1,454 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Tumor suppressor genes

1991 • 775 citations

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA) structural conservation and the detection of a nucleolar form

1990 • 736 citations

Atypical carcinoid tumors of the lung

1972 • 578 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Point Mutational Inactivation of the Retinoblastoma Antioncogene

1989 • 427 citations

Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma.

1990 • 342 citations

Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro

1990 • 283 citations

p53 expression in colorectal tumors.

1991 • 243 citations

Altered Expression of the Retinoblastoma Gene Product in Human Sarcomas

1990 • 221 citations

Histopathologic classification of small cell lung cancer changing concepts and terminology

1988 • 220 citations

Neuroendocrine Differentiation in Endocrine and Nonendocrine Lung Carcinomas

1988 • 191 citations

Expression of the nuclear oncogene p53 in colon tumours

1989 • 173 citations

Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer

1991 • 158 citations

Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.

1990 • 149 citations

New approach to assessing lung tumours in man.

1986 • 113 citations

The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells.

1989 • 104 citations

The pathology of lung cancer--changing concepts and newer diagnostic techniques.

1988 • 102 citations

Vimentin and p53 expression on epidermal growth factor receptor-positive, oestrogen receptor-negative breast carcinomas

1988 • 92 citations

Immunohistochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung

1987 • 85 citations

The role of differentiation in the suppression of malignancy*

1990 • 61 citations

Epitopes on proliferating cell nuclear antigen recognized by human lupus autoantibody and murine monoclonal antibody.

1987 • 58 citations

Immunohistochemical evidence of abnormal expression of the antioncogene-encoded p53 phosphoprotein in Hodgkin's disease and CD30+ anaplastic lymphomas.

1991 • 55 citations

Well differentiated and small cell neuroendocrine carcinomas of the lung

1988 • 47 citations