NYVAC-Pf7: a poxvirus-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria

A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

1938 • 19,183 citations

A simple method of estimating 50 per cent end points

1938 • 8,381 citations

The complete DNA sequence of vaccinia virus

1990 • 847 citations

Molecular analysis of the association of HLA-B53 and resistance to severe malaria

1992 • 645 citations

Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.

1985 • 526 citations

Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites

1987 • 512 citations

NYVAC: A highly attenuated strain of vaccinia virus

1992 • 473 citations

Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.

1994 • 453 citations

Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection.

1980 • 439 citations

SAFETY AND EFFICACY OF A RECOMBINANT DNA PLASMODIUM FALCIPARUM SPOROZOITE VACCINE

1987 • 428 citations

Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1)

1993 • 389 citations

A vaccine candidate from the sexual stage of human malaria that contains EGF-like domains

1988 • 375 citations

Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria.

1987 • 311 citations

Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters.

1983 • 296 citations

Rationale for the Development of an Engineered Sporozoite Malaria Vaccine

1989 • 295 citations

Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine

1991 • 290 citations

Construction of live vaccines using genetically engineered poxviruses: biological activity of vaccinia virus recombinants expressing the hepatitis B virus surface antigen and the herpes simplex virus glycoprotein D.

1984 • 287 citations

Induction of protective immunity against experimental infection with malaria using synthetic peptides

1987 • 282 citations

Oligonucleotide sequence signaling transcriptional termination of vaccinia virus early genes.

1987 • 280 citations

Differential localization of full-length and processed forms of PF83/AMA-1 an apical membrane antigen of Plasmodium falciparum merozoites

1994 • 267 citations

Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria.

1993 • 265 citations

Oral Salmonella typhimurium Vaccine Expressing Circumsporozoite Protein Protects Against Malaria

1988 • 250 citations

Expression of the HTLV-III envelope gene by a recombinant vaccinia virus

1986 • 240 citations

Major surface antigen gene of a human malaria parasite cloned and expressed in bacteria

1984 • 230 citations

Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin.

1983 • 225 citations

Recombinant Pfs25 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in experimental animals.

1991 • 217 citations

Characterization of Plasmodium falciparum sporozoite surface protein 2.

1992 • 210 citations

Expression of Plasmodium falciparum Circumsporozoite Proteins in Escherichia coli for Potential Use in a Human Malaria Vaccine

1985 • 210 citations

Vaccinia Virus Recombinant Expressing Herpes Simplex Virus Type 1 Glycoprotein D Prevents Latent Herpes in Mice

1985 • 210 citations

Oral Salmonella: malaria circumsporozoite recombinants induce specific CD8+ cytotoxic T cells.

1990 • 207 citations

Japanese encephalitis virus-vaccinia recombinants produce particulate forms of the structural membrane proteins and induce high levels of protection against lethal JEV infection

1991 • 202 citations

Vaccination with SPf66, a chemically synthesised vaccine, against Plasmodium falciparum malaria in Colombia

1993 • 200 citations

Expression of AIDS virus envelope gene in recombinant vaccinia viruses

1986 • 192 citations

Recombinant Vaccinia Virus: Immunization Against Multiple Pathogens

1985 • 192 citations

Immunogenicity and In Vivo Efficacy of Recombinant Plasmodium falciparum Merozoite Surface Protein-1 in Aotus Monkeys

1995 • 189 citations

Antimalarial immunity in Saimiri monkeys. Immunization with surface components of asexual blood stages.

1984 • 188 citations

Protection against malaria by vaccination with sporozoite surface protein 2 plus CS protein

1991 • 188 citations

Vaccination trials in rhesus monkeys with a minor, invariant, Plasmodium knowlesi 66 kD merozoite antigen

1988 • 175 citations

Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus

1990 • 172 citations

Protective Immunity Induced in Squirrel Monkeys with Recombinant Apical Membrane Antigen-1 of Plasmodium fragile

1994 • 172 citations

Mice immunized with a subviral particle containing the japanese encephalitis virus prM/M and E proteins are protected from lethal JEV infection

1992 • 169 citations

A liver-stage-specific antigen of Plasmodium falciparum characterized by gene cloning

1987 • 157 citations

Cloning and expression of foreign genes in vaccinia virus, using a host range selection system

1989 • 151 citations

Temporal regulation of influenza hemagglutinin expression in vaccinia virus recombinants and effects on the immune response

1986 • 149 citations

Localization, biosynthesis, processing and isolation of a major 126 kDa antigen of the parasitophorous vacuole of Plasmodium falciparum

1987 • 126 citations

Derepression of a novel class of vaccinia virus genes upon DNA replication.

1988 • 117 citations

Ability of recombinant or native proteins to protect monkeys against heterologous challenge with Plasmodium falciparum

1991 • 103 citations

Induction of Cytotoxic T Lymphocytes by Recombinant Canarypox (ALVAC) and Attenuated Vaccinia (NYVAC) Viruses Expressing the HIV-1 Envelope Glycoprotein

1993 • 97 citations

T-cell responses to human AIDS virus in macaques immunized with recombinant vaccinia viruses

1986 • 91 citations

Protective immunity induced in Aotus monkeys by recombinant SERA proteins of Plasmodium falciparum

1991 • 86 citations

Protection against malaria in Aotus monkeys immunized with a recombinant blood-stage antigen fused to a universal T-cell epitope: correlation of serum gamma interferon levels with protection

1992 • 84 citations

A Population-Based Clinical Trial with the SPf66 Synthetic Plasmodium falciparum Malaria Vaccine in Venezuela

1994 • 82 citations

Sequence and transcriptional analysis of the vaccinia virus HindIII I fragment

1988 • 80 citations

Recombinant vaccinia virus induces neutralising antibodies in rabbits against Epstein-Barr virus membrane antigen gp340.

1985 • 77 citations

Induction of Plasmodium falciparum Transmission-blocking Antibodies by Recombinant Vaccinia Virus

1991 • 76 citations

Immunity to malaria elicited by hybrid hepatitis B virus core particles carrying circumsporozoite protein epitopes.

1994 • 76 citations

Structure of Plasmodium falciparum liver stage antigen-1

1991 • 75 citations

Analysis of variation in PF83, an erythrocytic merozoite vaccine candidate antigen of Plasmodium falciparum

1990 • 73 citations

Protein p126: a parasitophorous vacuole antigen associated with the release of Plasmodium falciparum merozoites

1988 • 73 citations

Monoclonal antibody characterization of the 195-kilodalton major surface glycoprotein of Plasmodium falciparum malaria schizonts and merozoites: identification of additional processed products and a serotype-restricted repetitive epitope.

1987 • 72 citations

Poxvirus-based vectors as vaccine candidates.

1990 • 72 citations

Plasmodium falciparum: Immunogenicity of circumsporozoite protein constructs produced in Escherichia coli

1987 • 66 citations

Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: further studies using SERA 1 and MF75.2 adjuvant

1993 • 64 citations

Immunization of Aotus monkeys with Plasmodium falciparum blood-stage recombinant proteins.

1990 • 59 citations

Plasmodium falciparum: Gene structure and hydropathy profile of the major merozoite surface antigen (gp195) of the Uganda-Palo Alto isolate

1988 • 59 citations

Protection of Guinea Pigs from Primary and Recurrent Herpes Simplex Virus (HSV) Type 2 Cutaneous Disease with Vaccinia Virus Recombinants Expressing HSV Glycoprotein D

1987 • 54 citations

Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: adjuvant effects on induction of protective immunity

1993 • 53 citations

The circumsporozoite protein gene from NF54, a Plasmodium falciparum isolate used in malaria vaccine trials

1989 • 52 citations

Coexpression by vaccinia virus recombinants of equine herpesvirus 1 glycoproteins gp13 and gp14 results in potentiated immunity

1990 • 50 citations

Immunization against Plasmodium falciparum with recombinant polypeptides produced in Escherichia coli

1988 • 47 citations

Non-CS pre-erythrocytic protective antigens

1990 • 44 citations

Vaccination of pigs against pseudorabies with highly attenuated vaccinia (NYVAC) recombinant viruses

1993 • 40 citations

Mature liver stages of cloned Plasmodium falciparum share epitopes with proteins from sporozoites and asexual blood stages

1988 • 40 citations

A 60-kDa Plasmodium falciparum protein at the moving junction formed between merozoite and erythrocyte during invasion

1989 • 38 citations

Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria

1996 • 37 citations

Failure of recombinant vaccinia viruses expressing Plasmodium falciparum antigens to protect Saimiri monkeys against malaria

1991 • 34 citations

Fine specificities of monoclonal antibodies against the Plasmodium falciparum circumsporozoite protein: recognition of both repetitive and non‐repetitive regions

1991 • 31 citations

Generalized immunological recognition of the major merozoite surface antigen (gp195) of Plasmodium falciparum.

1989 • 24 citations

Studies using a recombinant vaccinia virus expressing the circumsporozoite protein of Plasmodium berghei

1991 • 23 citations

Methodology of using vaccinia virus to express foreign genes in tissue culture

1993 • 22 citations

A histidin alanine rich recombinant antigen protects Aotus monkeys from P. falciparum infection.

1988 • 19 citations

Antigen-presenting Capacity of Epidermal Cells Infected with Vaccinia Virus Recombinants Containing the Herpes Simplex Virus Glycoprotein D, and Protective Immunity

1989 • 17 citations

Use of a Vaccinia Construct Expressing the Circumsporozoite Protein in the Analysis of Protective Immunity to Plasmodium yoelii

1988 • 16 citations

Strategies for the development of an antimalarial vaccine

1992 • 10 citations

Vaccination against Malaria

1992 • 9 citations

Immunogenicity of the Plasmodium falciparum serine repeat antigen (p126) expressed by vaccinia virus

1993 • 6 citations

Malaria Vaccines

1992 • 2 citations

Laboratory Manual in Virology

1968 • 1 citations