Immunogenicity and In Vivo Efficacy of Recombinant Plasmodium falciparum Merozoite Surface Protein-1 in Aotus Monkeys

A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.

1990 • 562 citations

Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes.

1990 • 551 citations

Immunization against blood-stage rodent malaria using purified parasite antigens

1981 • 400 citations

Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1)

1993 • 389 citations

Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites

1985 • 286 citations

Proteolytic processing of thePlasmodium falciparum merozoite surface protein-1 produces a membrane-bound fragment containing two epidermal growth factor-like domains

1991 • 237 citations

The three major antigens on the surface of Plasmodium falciparum merozoites are derived from a single high molecular weight precursor.

1984 • 191 citations

A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmodium yoelii yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice

1993 • 189 citations

Immunization against malaria with a recombinant protein

1994 • 182 citations

A carboxyl-terminal fragment of Plasmodium falciparum gp195 expressed by a recombinant baculovirus induces antibodies that completely inhibit parasite growth.

1992 • 150 citations

Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination.

1992 • 135 citations

Production, Purification and Immunogenicity of a Malaria Transmission-Blocking Vaccine Candidate: TBV25H Expressed in Yeast and Purified Using Nickel-NTA Agarose

1994 • 131 citations

Expression, purification and characterization of recombinant marine granulocyte-macrophage colony-stimulating factor and bovine interleukin-2 from yeast

1987 • 86 citations

Expression and antigenicity of Plasmodium falciparum major merozoite surface protein (MSP119) variants secreted from Saccharomyces cerevisiae

1994 • 83 citations

Characteristics of the protective response of BALB/c mice immunized with a purified Plasmodium yoelii schizont antigen.

1983 • 63 citations

The major merozoite surface protein as a malaria vaccine target

1993 • 59 citations

Selection of Different Strains of Plasmodium falciparum for Testing Blood-Stage Vaccines in Aotus Nancymai Monkeys

1994 • 37 citations

Restriction polymorphisms and fingerprint patterns from an interspersed repetitive element of Plasmodium falciparum DNA

1993 • 34 citations

Molecular basis for mutation in a surface protein expressed by malaria parasites

1988 • 28 citations

Vaccination with a purified blood-stage malaria antigen in mice: correlation of protection with T cell mediated immunity.

1985 • 17 citations