Malaria Vaccines

Gamma-Globulin and Acquired Immunity to Human Malaria

1961 • 1,404 citations

Structure of the Gene Encoding the Immunodominant Surface Antigen on the Sporozoite of the Human Malaria Parasite Plasmodium falciparum

1984 • 716 citations

γ Interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites

1987 • 699 citations

A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.

1990 • 562 citations

Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites

1987 • 512 citations

Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria

1989 • 505 citations

CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.

1988 • 477 citations

Allelic dimorphism in a surface antigen gene of the malaria parasite Plasmodium falciparum

1987 • 471 citations

Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection.

1980 • 439 citations

SAFETY AND EFFICACY OF A RECOMBINANT DNA PLASMODIUM FALCIPARUM SPOROZOITE VACCINE

1987 • 428 citations

A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

1988 • 413 citations

Immunization against blood-stage rodent malaria using purified parasite antigens

1981 • 400 citations

A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules

1988 • 384 citations

Immunity to Malaria: Antigenic Variation in Chronic Infections of Plasmodium knowlesi

1965 • 383 citations

Immunization of Man against Falciparum and Vivax Malaria by Use of Attenuated Sporozoites *

1975 • 375 citations

A vaccine candidate from the sexual stage of human malaria that contains EGF-like domains

1988 • 375 citations

A Plasmodium falciparum Antigen that Binds to Host Erythrocytes and Merozoites

1985 • 339 citations

Sequential expression of antigens on sexual stages of Plasmodium falciparum accessible to transmission-blocking antibodies in the mosquito.

1985 • 339 citations

Antigens Induced on Erythrocytes by P. falciparum : Expression of Diverse and Conserved Determinants

1986 • 331 citations

Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria.

1990 • 322 citations

Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria.

1987 • 311 citations

Carrier-induced epitopic suppression, a major issue for future synthetic vaccines.

1985 • 298 citations

Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites

1985 • 286 citations

Induction of protective immunity against experimental infection with malaria using synthetic peptides

1987 • 282 citations

Construction of Synthetic Immunogen: Use of New T-Helper Epitope on Malaria Circumsporozoite Protein

1987 • 270 citations

Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule.

1988 • 264 citations

Antibodies in malarial sera to parasite antigens in the membrane of erythrocytes infected with early asexual stages of Plasmodium falciparum.

1984 • 264 citations

Circumsporozoite Protein Heterogeneity in the Human Malaria Parasite Plasmodium vivax

1989 • 255 citations

Oral Salmonella typhimurium Vaccine Expressing Circumsporozoite Protein Protects Against Malaria

1988 • 250 citations

Integral membrane protein located in the apical complex of Plasmodium falciparum.

1989 • 244 citations

Identification of two integral membrane proteins of Plasmodium falciparum.

1988 • 242 citations

Target antigens of transmission-blocking immunity on gametes of plasmodium falciparum.

1983 • 235 citations

Multiple cross‐reactivities amongst antigens of Plasmodium falciparum impair the development of protective immunity against malaria

1986 • 235 citations

Synthetic peptide vaccine confers protection against murine malaria.

1987 • 232 citations

Protective monoclonal antibodies recognising stage-specific merozoite antigens of a rodent malaria parasite

1980 • 226 citations

Prevention of vaccinia virus infection in imiminodeficient mice by vector-directed IL-2 expression

1987 • 216 citations

Expression of Plasmodium falciparum Circumsporozoite Proteins in Escherichia coli for Potential Use in a Human Malaria Vaccine

1985 • 210 citations

Naturally Acquired Antibodies to Sporozoites Do Not Prevent Malaria: Vaccine Development Implications

1987 • 209 citations

Recovery of immunodeficient mice from a vaccinia virus/IL-2 recombinant infection

1987 • 198 citations

Malaria transmission blocked by immunisation with gametes of the malaria parasite

1976 • 195 citations

Structural diversity in the 45-kilodalton merozoite surface antigen of Plasmodium falciparum

1990 • 189 citations

Structure of the RESA gene ofPiasmodium falciparum

1986 • 185 citations

The 230-kDa gamete surface protein of Plasmodium falciparum is also a target for transmission-blocking antibodies.

1987 • 185 citations

Immunization of Aotus monkeys with recombinant proteins of an erythrocyte surface antigen of Plasmodium falciparum

1986 • 184 citations

Malaria: Successful Immunization Against the Sexual Stages of Plasmodium gallinaceum

1976 • 182 citations

Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum

1988 • 180 citations

Sporozoite Vaccine Induces Genetically Restricted T Cell Elimination of Malaria from Hepatocytes

1989 • 177 citations

Vaccination trials in rhesus monkeys with a minor, invariant, Plasmodium knowlesi 66 kD merozoite antigen

1988 • 175 citations

The malaria vaccine: anti-parasite or anti-disease?

1990 • 170 citations

Efficacy of Murine Malaria Sporozoite Vaccines: Implications for Human Vaccine Development

1987 • 162 citations

A liver-stage-specific antigen of Plasmodium falciparum characterized by gene cloning

1987 • 157 citations

Induction of the proteolytic activity of a membrane protein in Plasmodium falciparum by phosphatidyl inositol-specific phospholipase C

1988 • 154 citations

Passive immunization against murine malaria with an IgG3 monoclonal antibody.

1984 • 152 citations

Antibodies to Plasmodium falciparum gamete surface antigens in Papua New Guinea sera

1988 • 152 citations

A rhoptry antigen of Plasmodium falciparum contains conserved and variable epitopes recognized by inhibitory monoclonal antibodies

1986 • 144 citations

Epitope-specific regulation. I. Carrier-specific induction of suppression for IgG anti-hapten antibody responses

1982 • 143 citations

Acylation of a Plasmodium falciparum merozoite surface antigen via sn-1,2-diacyl glycerol.

1985 • 142 citations

Inhibition of P. falciparum growth in human erythrocytes by monoclonal antibodies

1981 • 141 citations

Codon usage in Plasmodium falciparum

1988 • 134 citations

Antigenic variation of Plasmodium knowlesi malaria: identification of the variant antigen on infected erythrocytes.

1983 • 133 citations

Two approximately 300 kilodalton Plasmodium falciparum proteins at the surface membrane of infected erythrocytes

1988 • 128 citations

Roles of tumour necrosis factor in the illness and pathology of malaria

1989 • 127 citations

Pathogenicity, stability, and immunogenicity of a knobless clone of Plasmodium falciparum in Colombian owl monkeys

1985 • 127 citations

Malaria transmission-blocking immunity induced by natural infections of Plasmodium vivax in humans

1987 • 127 citations

Plasmodium falciparum ring-infected erythrocyte surface antigen is released from merozoite dense granules after erythrocyte invasion

1991 • 124 citations

An epitope recognised by inhibitory monoclonal antibodies that react with a 51 kilodalton merozoite surface antigen in Plasmodium falciparum

1988 • 123 citations

Ookinete antigens of Plasmodium berghei. Appearance on the zygote surface of an M_r 21 kD determinant identified by transmission‐blocking monoclonal antibodies

1988 • 119 citations

Immunity to Asexual Erythrocytic Stages of Plasmodium Falciparum: Role of Defined Antigens in the Humoral Response¹

1982 • 118 citations

Properties of epitopes of Pfs 48/45, a target of transmission blocking monoclonal antibodies, on gametes of different isolates of Plasmodium falciparum

1990 • 114 citations

Sequence variation in putative functional domains of the circumsporozoite protein of Plasmodium falciparum. Implications for vaccine development.

1987 • 111 citations

A malaria heat‐shock‐like determinant expressed on the infected hepatocyte surface is the target of antibody‐dependent cell‐mediated cytotoxic mechanisms by nonparenchymal liver cells

1990 • 110 citations

Isolation of a Plasmodium falciparum rhoptry protein

1985 • 109 citations

Restricted or absent immune responses in human populations to Plasmodium falciparum gamete antigens that are targets of malaria transmission-blocking antibodies.

1989 • 108 citations

Adoptive protection against Plasmodium chabaudi adami malaria in athymic nude mice by a cloned T cell line.

1988 • 107 citations

Plasmodium falciparum: Two antigens of similar size are located in different compartments of the rhoptry

1990 • 105 citations

Limited Immunological Recognition of Critical Malaria Vaccine Candidate Antigens

1988 • 103 citations

Assessment in humans of a synthetic peptide-based vaccine against the sporozoite stage of the human malaria parasite, Plasmodium falciparum.

1988 • 101 citations

Immunization with a Plasmodium falciparum merozoite surface antigen induces a partial immunity in monkeys.

1985 • 96 citations

A rhoptry antigen of Plasmodium falciparum is protective in Saimiri monkeys

1990 • 95 citations

Antibody-independent immunity to reinfection malaria in B-cell-deficient mice

1983 • 95 citations

Conserved Repetitive Epitope Recognized by CD4⁺Clones From a Malaria-Immunized Volunteer

1989 • 93 citations

Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei. Relevance to vaccine development.

1989 • 88 citations

Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine

1991 • 86 citations

Characterisation and sequence of a protective rhoptry antigen from Plasmodium falciparum

1990 • 85 citations

Development of sporozoite vaccines

1984 • 85 citations

Cross–reactive antigenic determinants present on different Plasmodium falciparum blood–stage antigens

1989 • 84 citations

Monoclonal and Polyclonal Antibodies Both Block and Enhance Transmission of Human Plasmodium Vivax Malaria

1988 • 84 citations

Malaria immunization in Rhesus monkeys. A vaccine effective against both the sexual and asexual stages of Plasmodium knowlesi.

1978 • 83 citations

Monoclonal antibodies that protect in vivo against Plasmodium chabaudi recognize a 250,000-dalton parasite polypeptide

1982 • 83 citations

Aldolase Activity of a Plasmodium falciparum Protein with Protective Properties

1988 • 83 citations

Genetic control of immunity to Plasmodium yoelii sporozoites.

1989 • 81 citations

The 140/130/105 kilodalton protein complex in the rhoptries of Plasmodium falciparum consists of discrete polypeptides

1988 • 80 citations

Characterization of the 175-kilodalton erythrocyte binding antigen of Plasmodium falciparum

1990 • 79 citations

46–53 Kilodalton glycoprotein from the surface of Plasmodium falciparum merozoites

1989 • 78 citations

Monoclonal Antibody Characterization of Plasmodium Falciparum Antigens

1984 • 78 citations

Biosynthesis of two stage-specific membrane proteins during transformation of Plasmodium gallinaceum zygotes into ookinetes

1985 • 78 citations

Kinetic constraints on the development of a malaria vaccine

1987 • 77 citations

A protective monoclonal antibody recognizes an epitope in the carboxyl-terminal cysteine-rich domain in the precursor of the major merozoite surface antigen of the rodent malarial parasite, Plasmodium yoelii.

1989 • 77 citations

Characterization of a 225 kilodalton rhoptry protein of Plasmodium falciparum

1988 • 77 citations

Immunity to Sporozoite-Induced Malaria Infection in Mice

1977 • 76 citations

Expression of the RESA gene in Plasmodium falciparum isolate FCR3 is prevented by a subtelomeric deletion.

1989 • 75 citations

Proteins Responsible for a Punctate Fluorescence Pattern in Plasmodium Falciparum Merozoites

1984 • 72 citations

Minimal variation in a vaccine candidate from the sexual stage of Plasmodium falciparum

1989 • 71 citations

An antigenic complex in the rhoptries of Plasmodium falciparum

1988 • 71 citations

Human lymphocyte proliferative response to a sporozoite T cell epitope correlates with resistance to falciparum malaria.

1989 • 70 citations

Plasmodium falciparum: An abundant stage-specific protein expressed during early gametocyte development

1989 • 70 citations

Adoptive transfer of CD8+ T cells from immune animals does not transfer immunity to blood stage Plasmodium yoelii malaria.

1990 • 69 citations

Variation in the precursor to the major merozoite surface antigens of Plasmodium falciparum

1988 • 66 citations

Plasmodium gallinaceum: Transmission-blocking immunity in chickens

1979 • 66 citations

Polymorphism of a 35–48 kDa Plasmodium falciparum merozoite surface antigen

1989 • 64 citations

In vitro and in vivo studies on protective and inhibitory antibodies against Plasmodium falciparum in the Saimiri monkey.

1984 • 64 citations

Third form of the precursor to the major merozoite surface antigens of Plasmodium falciparum.

1988 • 64 citations

The real difficulties for malaria sporozoite vaccine development: nonresponsiveness and antigenic variation

1988 • 63 citations

Boosting of transmission-blocking immunity during natural Plasmodium vivax infections in humans depends upon frequent reinfection

1988 • 63 citations

Human and murine macrophages produce TNF in response to soluble antigens of Plasmodium falciparum

1990 • 62 citations

Identification and characterisation of proteins associated with the rhoptry organelles of Plasmodium falciparum merozoites

1987 • 60 citations

Induction of protective immunity to monoclonal-antibody-defined Plasmodium falciparum antigens requires strong adjuvant in Aotus monkeys

1986 • 60 citations

Human T cell recognition of polymorphic epitopes from malaria circumsporozoite protein.

1989 • 59 citations

Location of human cytotoxic T cell epitopes within a polymorphic domain of the Plasmodium falciparum circumsporozoite protein

1991 • 55 citations

Human T clones reactive to the sexual stages of Plasmodium falciparum malaria. High frequency of gamete-reactive T cells in peripheral blood from nonexposed donors.

1987 • 54 citations

Differential non-Responsiveness in Humans of Candidate Plasmodium Falciparum Vaccine Antigens

1989 • 53 citations

Specificities of antibodies that inhibit merozoite dispersal from malaria-infected erythrocytes

1989 • 52 citations

Malaria: Host Responses to Infection

1989 • 52 citations

Reactivity of the human monoclonal antibody 33G2 with repeated sequences of three distinct Plasmodium falciparum antigens.

1989 • 52 citations

Inhibitory monoclonal antibody against a (myristylated) small-molecular-weight antigen from Plasmodium falciparum associated with the parasitophorous vacuole membrane

1988 • 50 citations

Cellular and humoral immune responses to Plasmodium falciparum gametocyte antigens in malaria-immune individuals. Limited response to the 48/45-kilodalton surface antigen does not appear to be due to MHC restriction.

1990 • 49 citations

Biosynthesis of a putative protective Plasmodium knowlesi merozoite antigen

1984 • 49 citations

Development of the human immune response against the major surface protein (gp190) of Plasmodium falciparum

1989 • 49 citations

Major population differences in T cell response to a malaria sporozite vaccine candidate

1990 • 48 citations

The ring-infected erythrocyte surface antigen protein of Plasmodium falciparum is phosphorylated upon association with the host cell membrane

1990 • 48 citations

Plasmodium knowlesi: Functional immunity and antimerozoite antibodies in rhesus monkeys after repeated infection

1977 • 47 citations

Survival and antigenic profile of irradiated malarial sporozoites in infected liver cells

1990 • 46 citations

Apical membrane antigen of Plasmodium fragile

1990 • 46 citations

The primary antibody response of malaria patients to Plasmodium falciparum sexual stage antigens which are potential transmission blocking vaccine candidates

1990 • 45 citations

Plasmodium berghei: Relationship between protective immunity and anti-sporozoite (CSP) antibody in mice

1973 • 44 citations

Allelic forms of gp195, a major blood-stage antigen of Plasmodium falciparum, are expressed in liver stages.

1988 • 42 citations

Lack of cross-reactivity between variant T cell determinants from malaria circumsporozoite protein.

1988 • 42 citations

Peptide-primed CD4+ cells and malaria sporozoites

1990 • 41 citations

Plasmodium berghei: T cell dependence of sporozoite-induced immunity in rodents

1977 • 41 citations

Cross–reactivity of antibody against an epitope of the Plasmodium falciparum second merozoite surface antigen

1989 • 41 citations

A 60-kDa Plasmodium falciparum protein at the moving junction formed between merozoite and erythrocyte during invasion

1989 • 38 citations

A protective monoclonal antibody recognizes a linear epitope in the precursor to the major merozoite antigens of Plasmodium chabaudi adami.

1989 • 38 citations

Demonstration of antigenic polymorphism in Plasmodium vivax malaria with a panel of 30 monoclonal antibodies

1987 • 37 citations

A 46000 dalton Plasmodium falciparum merozoite surface glycoprotein not related to the 185000?195000 dalton schizont precursor molecule: isolation and characterization

1988 • 36 citations

Vaccination with purified microgamete antigens prevents transmission of rodent malaria

1985 • 35 citations

Immunogenicity of Plasmodium falciparum sexual stage antigens: Implications for the design of a transmission blocking vaccine

1990 • 34 citations

Plasmodium falciparum sexual stage antigens: Immunogenicity and cell-mediated responses

1990 • 34 citations

Plasmodium knowlesi: persistence of transmission blocking immunity in monkeys immunized with gamete antigens

1984 • 34 citations

Immune response gene regulation of immunity to Plasmodium berghei sporozoites and circumsporozoite protein vaccines. Overcoming genetic restriction with whole organism and subunit vaccines.

1989 • 33 citations

Studies on the Transfer of Protective Immunity with Lymphoid Cells from Mice Immune to Malaria Sporozoites

1978 • 32 citations

Expression of the Precursor of the Major Merozoite Surface Antigens During the Hepatic Stage of Malaria

1989 • 31 citations

Target antigens of transmission blocking immunity of Plasmodium vivax malaria. Characterization and polymorphism in natural parasite isolates.

1990 • 26 citations

The immunologic significance of variation within malaria circumsporozoite protein sequences.

1989 • 26 citations

Biosynthesis of the 25-kDa protein in the macrogametes/zygotes of Plasmodium falciparum

1990 • 25 citations

Plasmodium falciparum: Sporozoite boosting of immunity due to a T-cell epitope on a sporozoite vaccine

1987 • 24 citations

Identification of a peptide sequence of the 25 kD surface protein of Plasmodium falciparum recognized by transmission‐blocking monoclonal antibodies: implications for synthetic vaccine development

1989 • 22 citations

Sequence coding for a sexual stage specific protein ofPlasmodium falciparum

1990 • 22 citations

In vivo testing of subunit vaccines against malaria sporozoites using a rodent system.

1987 • 22 citations

Invasion of erythrocytes in vitro by Plasmodium falciparum can be inhibited by monoclonal antibody directed against an S antigen

1985 • 21 citations

Topography of epitopes on a polymorphic schizont antigen of Plasmodium falciparum determined by the binding of monoclonal antibodies in a two‐site radioimmunoassay

1987 • 21 citations

High Frequency of Antibody Response to Plasmodium falciparum Gametocyte Antigens during Acute Malaria Infections in Papua New Guinea Highlanders

1990 • 19 citations

Monoclonal antibodies to a synthetic peptide corresponding to a repeated sequence in the Plasmodium falciparum antigen Pf155

1988 • 18 citations

Vaccination to prevent transmission of Plasmodium yoelii malaria

1982 • 17 citations

Synthetic gene construct expressing a repeated and highly immunogenic epitope of the Plasmodium falciparum antigen Pf155.

1987 • 17 citations

Three non‐repeated transmission blocking epitopes recognized in the 21 kD surface antigen of zygotes‐ookinetes of Plasmodium berghei

1990 • 17 citations

Characterization of epitopes on the 25 kD protein of the macrogametes/zygotes of Plasmodium falciparum

1989 • 15 citations

Immunogenicity and antigenicity in rabbits of a repeated sequence of Plasmodium falciparum antigen Pf155/RESA fused to two immunoglobulin G-binding domains of staphylococcal protein A

1990 • 13 citations

Variation of T cell epitopes of the Plasmodium falciparum CS protein: Its occurrence, extent and relevance

1990 • 8 citations

A portion of the Pf155/RESA antigen of Plasmodium falciparum is accessible on the surface of infected erythrocytes

1988 • 6 citations

Contrasts in antigen expression in the erythrocytic and exoerythrocytic stages of rodent malaria

1989 • 5 citations