Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria

Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

1968 • 1,363 citations

The complete DNA sequence of vaccinia virus

1990 • 847 citations

γ Interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites

1987 • 699 citations

Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.

1985 • 526 citations

Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites

1987 • 512 citations

Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria

1989 • 505 citations

CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.

1988 • 477 citations

NYVAC: A highly attenuated strain of vaccinia virus

1992 • 473 citations

Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.

1994 • 453 citations

Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection.

1980 • 439 citations

SAFETY AND EFFICACY OF A RECOMBINANT DNA PLASMODIUM FALCIPARUM SPOROZOITE VACCINE

1987 • 428 citations

Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.

1988 • 331 citations

Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria.

1990 • 322 citations

Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes.

1983 • 311 citations

Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters.

1983 • 296 citations

Rationale for the Development of an Engineered Sporozoite Malaria Vaccine

1989 • 295 citations

Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine

1991 • 290 citations

Construction of live vaccines using genetically engineered poxviruses: biological activity of vaccinia virus recombinants expressing the hepatitis B virus surface antigen and the herpes simplex virus glycoprotein D.

1984 • 287 citations

Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria.

1993 • 265 citations

Oral Salmonella typhimurium Vaccine Expressing Circumsporozoite Protein Protects Against Malaria

1988 • 250 citations

Expression of the HTLV-III envelope gene by a recombinant vaccinia virus

1986 • 240 citations

Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin.

1983 • 225 citations

Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells.

1994 • 211 citations

Vaccinia Virus Recombinant Expressing Herpes Simplex Virus Type 1 Glycoprotein D Prevents Latent Herpes in Mice

1985 • 210 citations

Oral Salmonella: malaria circumsporozoite recombinants induce specific CD8+ cytotoxic T cells.

1990 • 207 citations

Japanese encephalitis virus-vaccinia recombinants produce particulate forms of the structural membrane proteins and induce high levels of protection against lethal JEV infection

1991 • 202 citations

Expression of AIDS virus envelope gene in recombinant vaccinia viruses

1986 • 192 citations

Protection against malaria by vaccination with sporozoite surface protein 2 plus CS protein

1991 • 188 citations

Mice immunized with a subviral particle containing the japanese encephalitis virus prM/M and E proteins are protected from lethal JEV infection

1992 • 169 citations

Multiple T helper cell epitopes of the circumsporozoite protein of Plasmodium berghei

1988 • 163 citations

Efficacy of Murine Malaria Sporozoite Vaccines: Implications for Human Vaccine Development

1987 • 162 citations

Cloning and expression of foreign genes in vaccinia virus, using a host range selection system

1989 • 151 citations

Temporal regulation of influenza hemagglutinin expression in vaccinia virus recombinants and effects on the immune response

1986 • 149 citations

NYVAC-Pf7: a poxvirus-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria

1996 • 125 citations

Antibodies to the protective antigen of Plasmodium berghei sporozoites prevent entry into cultured cells.

1982 • 98 citations

Recombinant vaccinia virus expressing epstein‐barr virus glycoprotein gp340 protects cottontop tamarins against EB virus‐induced malignant lymphomas

1988 • 98 citations

Induction of Cytotoxic T Lymphocytes by Recombinant Canarypox (ALVAC) and Attenuated Vaccinia (NYVAC) Viruses Expressing the HIV-1 Envelope Glycoprotein

1993 • 97 citations

T-cell responses to human AIDS virus in macaques immunized with recombinant vaccinia viruses

1986 • 91 citations

Expression of dengue virus structural proteins and nonstructural protein NS1 by a recombinant vaccinia virus

1987 • 77 citations

Immunity to malaria elicited by hybrid hepatitis B virus core particles carrying circumsporozoite protein epitopes.

1994 • 76 citations

Poxvirus-based vectors as vaccine candidates.

1990 • 72 citations

Anchoring a Secreted Plasmodium Antigen on the Surface of Recombinant Vaccinia Virus-Infected Cells Increases Its Immunogenicity

1986 • 60 citations

Dengue 2 Virus Envelope Protein Expressed by a Recombinant Vaccinia Virus Fails to Protect Monkeys against Dengue

1988 • 55 citations

Protection of Guinea Pigs from Primary and Recurrent Herpes Simplex Virus (HSV) Type 2 Cutaneous Disease with Vaccinia Virus Recombinants Expressing HSV Glycoprotein D

1987 • 54 citations

Coexpression by vaccinia virus recombinants of equine herpesvirus 1 glycoproteins gp13 and gp14 results in potentiated immunity

1990 • 50 citations

Vaccination of pigs against pseudorabies with highly attenuated vaccinia (NYVAC) recombinant viruses

1993 • 40 citations

Failure of recombinant vaccinia viruses expressing Plasmodium falciparum antigens to protect Saimiri monkeys against malaria

1991 • 34 citations

Plasmodium berghei: Cloning of the circumsporozoite protein gene

1987 • 31 citations

Studies using a recombinant vaccinia virus expressing the circumsporozoite protein of Plasmodium berghei

1991 • 23 citations

In vivo testing of subunit vaccines against malaria sporozoites using a rodent system.

1987 • 22 citations

Methodology of using vaccinia virus to express foreign genes in tissue culture

1993 • 22 citations

Sequence of the circumsporozoite gene of Plasmodium berghei ANKA clone and NK65 strain

1990 • 21 citations

Use of a Vaccinia Construct Expressing the Circumsporozoite Protein in the Analysis of Protective Immunity to Plasmodium yoelii

1988 • 16 citations

Immune Response to Plasmodium Berghei Sporozoite Antigens. I. Evaluation of Murine T Cell Repertoire Following Immunization with Irradiated Sporozoites

1990 • 12 citations

Immunization with irradiated Plasmodium berghei sporozoites induces IL‐2 and IFNγ but not IL‐4

1994 • 6 citations

Immunogenicity of the Plasmodium falciparum serine repeat antigen (p126) expressed by vaccinia virus

1993 • 6 citations

Recent Advances in Recombinant Vaccines for Viral and Parasitic Diseases

1994 • 2 citations