The Novel Synthetic Retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) Causes Apoptosis in Acute Promyelocytic Leukemia Cells Through Rapid Activation of Caspases

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1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

1984 • 973 citations

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)

1991 • 884 citations

Acute Promyelocytic Leukemia

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The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

1993 • 602 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

1997 • 486 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia

1997 • 430 citations

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1998 • 421 citations

Constitutive expression of the machinery for programmed cell death.

1996 • 386 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis

1996 • 327 citations

PML, a growth suppressor disrupted in acute promyelocytic leukemia.

1994 • 296 citations

Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis.

1997 • 259 citations

Flow cytometric detection of apoptosis: Comparison of the assays of in situ DNA degradation and chromatin changes

1994 • 235 citations

Acute promyelocytic leukemia

1986 • 224 citations

Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.

1996 • 223 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells.

1997 • 209 citations

Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ

1992 • 205 citations

Two distinct actions of retinoid-receptor ligands

1996 • 200 citations

Treatment With a New Synthetic Retinoid, Am80, of Acute Promyelocytic Leukemia Relapsed From Complete Remission Induced by All-trans Retinoic Acid

1997 • 191 citations

Combined Arsenic and Retinoic Acid Treatment Enhances Differentiation and Apoptosis in Arsenic-Resistant NB4 Cells

1998 • 160 citations

Retinoid-Induced Apoptosis and Sp1 Cleavage Occur Independently of Transcription and Require Caspase Activation

1997 • 140 citations

Processing/Activation of At Least Four Interleukin-1β Converting Enzyme–like Proteases Occurs during the Execution Phase of Apoptosis in Human Monocytic Tumor Cells

1997 • 135 citations

Retinoid Induced Apoptosis in Leukemia Cells Through a Retinoic Acid Nuclear Receptor-Independent Pathway

1997 • 132 citations

Stat1 Is Induced and Activated by All-Trans Retinoic Acid in Acute Promyelocytic Leukemia Cells

1997 • 120 citations

Induction of apoptosis in human leukemic cells by the ether lipid 1‐octadecyl‐2‐methyl‐RAC‐glycero‐3‐ phosphocholine. A possible basis for its selective action

1993 • 115 citations

Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RAR alpha protein

1993 • 111 citations

Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo.

1996 • 106 citations

A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features.

1992 • 89 citations

Posttranscriptional regulation of p21WAF1/CIP1 expression in human breast carcinoma cells.

1996 • 89 citations

AGN193109 Is a Highly Effective Antagonist of Retinoid Action in Human Ectocervical Epithelial Cells

1996 • 83 citations

Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437

1997 • 77 citations

Retinoic acid and granulocyte colony-stimulating factor synergistically induce leukocyte alkaline phosphatase in acute promyelocytic leukemia cells

1994 • 70 citations

Rapid induction of apoptosis in human C33A cervical carcinoma cells by the synthetic retinoid 6-[3-(1-adamantyl)hydroxyphenyl]-2-naphtalene carboxylic acid (CD437)

1997 • 67 citations

AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells

1996 • 65 citations

Retinoic acid and granulocyte colony-stimulating factor synergistically induce leukocyte alkaline phosphatase in acute promyelocytic leukemia cells

1994 • 62 citations

Identification of the First Retinoid X Receptor Homodimer Antagonist

1996 • 58 citations

Inhibition of Cell Proliferation and Induction of Apoptosis by the Retinoid AHPN in Human Lung Carcinoma Cells

1998 • 57 citations

Expression of leukocyte alkaline phosphatase gene in normal and leukemic cells: regulation of the transcript by granulocyte colony- stimulating factor

1990 • 53 citations

Prolonged follow-up confirms that all-trans retinoic acid followed by chemotherapy reduces the risk of relapse in newly diagnosed acute promyelocytic leukemia. The French APL Group [letter]

1994 • 43 citations

All-trans retinoic acid and cyclic adenosine monophosphate cooperate in the expression of leukocyte alkaline phosphatase in acute promyelocytic leukemia cells

1995 • 42 citations

Inhibition of ICE-Related Proteases (Caspases) and Nuclear Apoptosis by Phenylarsine Oxide

1997 • 40 citations

Effects of Synthetic Retinoids and Retinoic Acid Isomers on the Expression of Alkaline Phosphatase in F9 Teratocarcinoma Cells

1993 • 39 citations

Differential changes of retinoid-X-receptor (RXR alpha) and its RAR alpha and PML-RAR alpha partners induced by retinoic acid and cAMP distinguish maturation sensitive and resistant t(15;17) promyelocytic leukemia NB4 cells.

1996 • 36 citations

Chemotherapeutic Drug Activation of the AP24 Protease in Apoptosis: Requirement for Caspase 3-like-Proteases

1998 • 31 citations

The molecular genetics of acute promyelocytic leukemia

1993 • 30 citations

Bcl-XLExpression and Its Downregulation by a Novel Retinoid in Breast Carcinoma Cells

1997 • 26 citations

Differentiation therapy in acute promyelocytic leukemia: European experience

1997 • 24 citations

Effects of Various Synthetic Retinoids on Proliferation and Immunophenotype of Human Melanoma Cells In Vitro

1995 • 20 citations

In vitro treatment with retinoids or the topoisomerase inhibitor, VP-16, evidences different functional apoptotic pathways in acute promyelocytic leukemic cells.

1995 • 20 citations

Effects of 1,25-Dihydroxy Vitamin D3 on All-Trans Retinoic Acid Sensitive and Resistant Acute Promyelocytic Leukemia Cells

1996 • 18 citations

Growth, Differentiation, and Death of Retinoic Acid-Treated Human Acute Promyelocytic Leukemia NB4 Cells

1997 • 17 citations

Genetics of APL and the molecular basis of retinoic acid treatment

1997 • 7 citations

Molecular mechanisms of retinoid action in acute promyelocytic leukemia (Review)

1997 • 4 citations