Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

1990 • 1,763 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Giant-cell tumor of bone.

1987 • 1,228 citations

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1991 • 1,176 citations

Molecular cloning of a new transforming gene from a chemically transformed human cell line

1984 • 966 citations

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.

1993 • 707 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

1992 • 571 citations

Tyrosine kinase receptor indistinguishable from the c-met protein

1989 • 496 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer.

1995 • 447 citations

Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII

1993 • 373 citations

Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation.

1994 • 363 citations

Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma.

1995 • 329 citations

Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas.

1992 • 317 citations

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

1992 • 316 citations

Enhanced Tumorigenicity and Invasion-Metastasis by Hepatocyte Growth Factor/Scatter Factor-Met Signalling in Human Cells Concomitant with Induction of the Urokinase Proteolysis Network

1996 • 312 citations

The receptor encoded by the human C‐MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors

1991 • 291 citations

The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit.

1995 • 281 citations

Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product

1993 • 281 citations

Mechanisms of p53 loss in human sarcomas.

1990 • 273 citations

Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer.

1995 • 267 citations

Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE

1991 • 253 citations

Biosynthesis of the protein encoded by the c-met proto-oncogene.

1989 • 220 citations

Lung may have an endocrine function producing hepatocyte growth factor in response to injury of distal organs

1992 • 212 citations

Osteosarcoma: Fifteen Years Later

1985 • 194 citations

Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.

1988 • 183 citations

c-fos expression induces bone tumors in transgenic mice.

1989 • 177 citations

c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase.

1991 • 170 citations

Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene.

1993 • 159 citations

p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas

1993 • 145 citations

Met expression and sarcoma tumorigenicity.

1993 • 144 citations

Sequestration of a hepatocyte growth factor in extracellular matrix in normal adult rat liver

1991 • 105 citations

Studies of the retinoblastoma gene in human sarcomas.

1989 • 100 citations

Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells.

1993 • 81 citations

Sporadic amplification of the MYC gene in human osteosarcomas.

1993 • 67 citations

Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients.

1995 • 54 citations

Amplification of Both c‐myc and c‐raf‐1 Oncogenes in a Human Osteosarcoma

1989 • 48 citations

Expression of c‐sis and other cellular proto‐oncogenes in human sarcoma cell lines and biopsies

1989 • 14 citations

Inducibility of neoplastic transformation by Fujinami sarcoma virus in an in vitro chick embryo model for osteosarcoma: (I) Effect of differentiation and (II) investigation for in vivo growth potential in athymic mice

1991 • 5 citations