Regulation of cytomegalovirus gene expression: alpha and beta promoters are trans activated by viral functions in permissive human fibroblasts

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Experiments in molecular genetics

1972 • 28,260 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins

1974 • 1,479 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

Die Molekularbiologie der Tumorviren

1977 • 951 citations

An adenovirus type 5 early gene function regulates expression of other early viral genes.

1979 • 791 citations

Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs

1979 • 756 citations

Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.

1975 • 616 citations

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

1981 • 604 citations

Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription

1984 • 567 citations

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

1982 • 507 citations

Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK

1979 • 496 citations

Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells.

1983 • 471 citations

Regulation of α genes of herpes simplex virus: Expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters

1981 • 449 citations

Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175

1980 • 436 citations

A herpes simplex virus type 1 function continuously required for early and late virus RNA synthesis

1980 • 429 citations

Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes

1983 • 423 citations

Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity.

1984 • 396 citations

Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters

1985 • 345 citations

Structural analysis of the major immediate early gene of human cytomegalovirus

1984 • 342 citations

Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes

1982 • 315 citations

Temporal Patterns of Human Cytomegalovirus Transcription: Mapping the Viral RNAs Synthesized at Immediate Early, Early, and Late Times After Infection

1982 • 311 citations

Promoter-regulatory region of the major immediate early gene of human cytomegalovirus.

1984 • 296 citations

Organization and expression of the immediate early genes of human cytomegalovirus

1983 • 288 citations

Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome

1977 • 274 citations

Activation of the major immediate early gene of human cytomegalovirus by cis-acting elements in the promoter-regulatory sequence and by virus-specific trans-acting components

1985 • 245 citations

Bacterial beta-galactosidase as a marker of Rous sarcoma virus gene expression and replication.

1985 • 206 citations

Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169

1983 • 199 citations

Molecular engineering of the herpes simplex virus genome: Insertion of a second L-S junction into the genome causes additional genome inversions

1980 • 185 citations

Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells.

1983 • 178 citations

Human cytomegalovirus DNA: Restriction enzyme cleavage maps and map locations for immediate-early, early, and late RNAs

1981 • 171 citations

Evidence that herpes simplex virus DNA is transcribed by cellular RNA polymerase B

1977 • 163 citations

Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infection

1981 • 159 citations

Differentiation between alpha promoter and regulator regions of herpes simplex virus 1: the functional domains and sequence of a movable alpha regulator.

1982 • 148 citations

Separation of sequences defining basal expression from those conferring alpha gene recognition within the regulatory domains of herpes simplex virus 1 alpha genes.

1984 • 140 citations

The herpes simplex virus amplicon: analyses of cis-acting replication functions.

1985 • 136 citations

Regulation of herpesvirus macromolecular synthesis: transcription-initiation sites and domains of alpha genes.

1980 • 112 citations

Patterns of Transcription of Human Cytomegalovirus in Permissively Infected Cells

1980 • 111 citations

Cloning of the human cytomegalovirus genome as endonuclease XbaI fragments

1981 • 99 citations

The alpha sequence of the cytomegalovirus genome functions as a cleavage/packaging signal for herpes simplex virus defective genomes

1985 • 89 citations

gamma 2-Thymidine kinase chimeras are identically transcribed but regulated a gamma 2 genes in herpes simplex virus genomes and as beta genes in cell genomes.

1985 • 85 citations

Functional analysis of the steroid hormone control region of mouse mammary tumor virus

1984 • 84 citations

Regulation in vivo of a cloned mammalian gene: cadmium induces the transcription of a mouse metallothionein gene in SV40 vectors.

1982 • 82 citations

Transactivation of plasmid-borne promoters by adenovirus and several herpes group viruses

1984 • 81 citations

Analysis of the major transcripts encoded by the long repeat of human cytomegalovirus strain AD169

1985 • 78 citations

Regulation of α Genes of Herpes Simplex Virus: The α 27 Gene Promoter-Thymidine Kinase Chimera Is Positively Regulated in Converted L Cells

1982 • 70 citations

Post-transcriptional control of human cytomegalovirus gene expression

1983 • 69 citations

Physical mapping of human cytomegalovirus genes: Identification of DNA sequences coding for a virion phosphoprotein of 71 kDa and a viral 65-kDa polypeptide

1984 • 68 citations

Precise localization of genes on large animal virus genomes: use of lambda gt11 and monoclonal antibodies to map the gene for a cytomegalovirus protein family.

1985 • 64 citations

"Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene.

1985 • 63 citations

Mapping functional domains in the promoter region of the herpes thymidine kinase gene.

1981 • 56 citations

Bacterial β-Galactosidase as a Marker of Rous Sarcoma Virus Gene Expression and Replication

1985 • 54 citations

γ₂-Thymidine Kinase Chimeras Are Identically Transcribed but Regulated a γ₂ Genes in Herpes Simplex Virus Genomes and as β Genes in Cell Genomes

1985 • 53 citations

Molecular Biology of Cytomegaloviruses

1983 • 51 citations

Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences

1983 • 36 citations

Multiplicity Reactivation of Human Cytomegalovirus Inactivated by Ultra-violet Light

1974 • 22 citations