Activation of a mammalian origin of replication by chromosomal rearrangement.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Genomic sequencing.

1984 • 8,343 citations

Rapid transfer of DNA from agarose gels to nylon membranes

1985 • 1,810 citations

Isolation of High‐Molecular‐Weight DNA from Mammalian Cells

1973 • 1,723 citations

The localization of replication origins on ARS plasmids in S. cerevisiae

1987 • 1,051 citations

On the mechanism of DNA replication in mammalian chromosomes

1968 • 950 citations

A small cosmid for efficient cloning of large DNA fragments

1980 • 829 citations

Replication Timing of Genes and Middle Repetitive Sequences

1984 • 561 citations

A replication fork barrier at the 3′ end of yeast ribosomal RNA genes

1988 • 555 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Identification of an origin of bidirectional DNA replication in mammalian chromosomes

1990 • 288 citations

Replication initiates in a broad zone in the amplified CHO dihydrofolate reductase domain

1990 • 287 citations

Replication program of active and inactive multigene families in mammalian cells.

1988 • 247 citations

Isolation of human sequences that replicate autonomously in human cells.

1989 • 244 citations

Mapping replication units in animal cells

1989 • 232 citations

Cosmid vectors for rapid genomic walking, restriction mapping, and gene transfer.

1987 • 222 citations

A Novel Chromosome Abnormality in Human Neuroblastoma and Antifolate-Resistant Chinese Hamster Cell Lines in Culture 1 2

1976 • 213 citations

An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments.

1982 • 197 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

Mapping of replication initiation sites in mammalian genomes by two-dimensional gel analysis: stabilization and enrichment of replication intermediates by isolation on the nuclear matrix.

1991 • 153 citations

Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation.

1991 • 140 citations

High-resolution mapping of replication fork movement through the amplified dihydrofolate reductase domain in CHO cells by in-gel renaturation analysis.

1989 • 134 citations

Replication in the amplified dihydrofolate reductase domain in CHO cells may initiate at two distinct sites, one of which is a repetitive sequence element.

1989 • 130 citations

Isolation of the origin of replication associated with the amplified Chinese hamster dihydrofolate reductase domain.

1986 • 116 citations

Isolation of Human Sequences That Replicate Autonomously in Human Cells

1989 • 100 citations

Isolation of the amplified dihydrofolate reductase domain from methotrexate-resistant Chinese hamster ovary cells.

1987 • 97 citations

Replication Program of Active and Inactive Multigene Families in Mammalian Cells

1988 • 91 citations

Autonomous replication of plasmids bearing monkey DNA origin-enriched sequences.

1987 • 83 citations

Organization and genesis of dihydrofolate reductase amplicons in the genome of a methotrexate-resistant Chinese hamster ovary cell line.

1988 • 66 citations

Temporal Order of Gene Replication in Chinese Hamster Ovary Cells

1989 • 63 citations

Mapping of Replication Initiation Sites in Mammalian Genomes by Two-Dimensional Gel Analysis: Stabilization and Enrichment of Replication Intermediates by Isolation on the Nuclear Matrix

1991 • 53 citations

Replication in the Amplified Dihydrofolate Reductase Domain in CHO Cells May Initiate at Two Distinct Sites, One of Which Is a Repetitive Sequence Element

1989 • 50 citations

Multiple origins of replication in the dihydrofolate reductase amplicons of a methotrexate-resistant chinese hamster cell line.

1990 • 48 citations

Polarity of DNA replication through the avian alpha-globin locus.

1986 • 44 citations

Autonomous replicating sequences from mouse cells which can replicate in mouse cells in vivo and in vitro.

1987 • 37 citations

Isolation of the Amplified Dihydrofolate Reductase Domain from Methotrexate-Resistant Chinese Hamster Ovary Cells

1987 • 34 citations

Temporal order of gene replication in Chinese hamster ovary cells.

1989 • 32 citations

Identification and characterization of a gene that is coamplified with dihydrofolate reductase in a methotrexate-resistant CHO cell line.

1989 • 28 citations

The dihydrofolate reductase amplicons in different methotrexate-resistant Chinese hamster cell lines share at least a 273-kilobase core sequence, but the amplicons in some cell lines are much larger and are remarkably uniform in structure.

1988 • 28 citations

Repetitive sequence elements in an initiation locus of the amplified dihydrofolate reductase domain in CHO cells

1990 • 22 citations

Autonomous Replicating Sequences from Mouse Cells Which can Replicate in Mouse Cells in Vivo and in Vitro

1987 • 14 citations

Identification and Characterization of a Gene That Is Coamplified with Dihydrofolate Reductase in a Methotrexate-Resistant CHO Cell Line

1989 • 10 citations