Secretory lysosomes — a special mechanism of regulated secretion in haemopoietic cells

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

B lymphocytes secrete antigen-presenting vesicles.

1996 • 3,198 citations

Identification of the homologous beige and Chediak–Higashi syndrome genes

1996 • 536 citations

The Chediak-Higashi syndrome: studies in four patients and a review of the literature.

1972 • 398 citations

Polarized secretion of lysosomal enzymes: co-distribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway.

1988 • 209 citations

Identification of the murine beige gene by YAC complementation and positional cloning

1996 • 193 citations

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.

1993 • 177 citations

Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi (beige) mice.

1975 • 173 citations

Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis.

1995 • 165 citations

Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts.

1993 • 144 citations

Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments.

1995 • 144 citations

Phagocytosis in Chronic Granulomatous Disease and the Chediak–Higashi Syndrome

1972 • 141 citations

The giant organelles in beige and Chediak-Higashi fibroblasts are derived from late endosomes and mature lysosomes.

1993 • 131 citations

Chediak-Higashi gene in humans. II. The selectivity of the defect in natural- killer and antibody-dependent cell-mediated cytotoxicity function

1980 • 110 citations

DISTRIBUTION OF ANOMALOUS LYSOSOMES IN THE BEIGE MOUSE: A HOMOLOGUE OF CHEDIAK-HIGASHI SYNDROME

1973 • 97 citations

Neutrophilic Function in Animals with the Chediak-Higashi Syndrome

1967 • 53 citations

Calcium-induced translocation of annexins to subcellular organelles of human neutrophils

1994 • 47 citations

Aberrant T cells in beige mutant mice.

1987 • 42 citations

Mast cell degranulation in beige mice with the Chédiak-Higashi defect.

1981 • 14 citations