Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.

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1980 • 317 citations

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1988 • 258 citations

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1986 • 251 citations

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

1984 • 214 citations

Randomized clinical trial of mitomycin c as an adjunct to radiotherapy in head and neck cancer

1989 • 204 citations

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

1984 • 178 citations

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Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: Results from two randomized clinical trials

1993 • 134 citations

Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.

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Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase

1982 • 113 citations

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Activation of mitomycin C by NADPH:cytochrome P-450 reductase.

1990 • 102 citations

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1987 • 91 citations

Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7.

1989 • 87 citations

Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.

1990 • 85 citations

Interactions of mitomycin C with mammalian DNA detected by alkaline elution.

1985 • 84 citations

Metabolic activation of mitomycin C by liver microsomes and nuclei

1982 • 67 citations

DNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues.

1990 • 61 citations

DNA alkylation by enzyme-activated mitomycin C.

1986 • 57 citations

Preclinical studies of porfiromycin as an adjunct to radiotherapy.

1988 • 55 citations

Cytotoxicity and DNA Crosslinks Produced by Mitomycin Analogs in Aerobic and Hypoxic EMT6 Cells

1991 • 49 citations

Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia.

1992 • 41 citations

Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells.

1988 • 39 citations

Characterization of a human bladder cancer cell line selected for resistance to mitomycin C

1994 • 31 citations

Effects of glutathione and ethylxanthate on mitomycin C activation by isolated rat hepatic or EMT6 mouse mammary tumor nuclei.

1985 • 30 citations

Mechanism of differential sensitivity of human bladder cancer cells to mitomycin C and its analogue

1994 • 21 citations

Effect of deficiencies in DNA repair on the toxicity of mitomycin C and porfiromycin to CHO cells under aerobic and hypoxic conditions.

1991 • 17 citations

Diversity of penetration of anti‐cancer agents into solid tumours

1991 • 15 citations

Studies on the mechanism of the cytotoxic action of the mitomycin antibiotics in hypoxic and oxygenated EMT6 cells

1993 • 12 citations

Porfiromycin as an adjunct to radiation therapy in squamous cell carcinoma of the head and neck: Results of a phase I clinical trial

1993 • 10 citations

Reduction of anthracycline glycoside by NADPH--cytochrome P-450 reductase.

1979 • 7 citations