NCCN Guidelines Insights: Kidney Cancer, Version 2.2020

Global cancer statistics

2011 • 55,498 citations

Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening

2011 • 9,173 citations

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

2015 • 8,603 citations

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

2015 • 7,844 citations

Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

2009 • 7,749 citations

Mortality in relation to smoking: 40 years' observations on male British doctors

1994 • 5,782 citations

Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma

2007 • 5,572 citations

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

2015 • 5,526 citations

Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

2012 • 5,195 citations

Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

1998 • 4,380 citations

International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma

2011 • 4,371 citations

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

2010 • 4,281 citations

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

2002 • 4,254 citations

Fleischner Society: Glossary of Terms for Thoracic Imaging

2008 • 3,945 citations

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

2018 • 3,846 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

The IASLC Lung Cancer Staging Project: Proposals for the Revision of the TNM Stage Groupings in the Forthcoming (Seventh) Edition of the TNM Classification of Malignant Tumours

2007 • 3,597 citations

Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma

2007 • 3,560 citations

Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

2005 • 3,450 citations

Crizotinib versus Chemotherapy in AdvancedALK-Positive Lung Cancer

2013 • 3,211 citations

Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer

2013 • 3,023 citations

First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer

2014 • 2,914 citations

Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

2019 • 2,714 citations

Mechanisms of Bone Metastasis

2004 • 2,680 citations

Two Hundred Gastrointestinal Stromal Tumors

2000 • 2,510 citations

Screening for Lung Cancer: U.S. Preventive Services Task Force Recommendation Statement

2013 • 2,445 citations

Immune Checkpoint Blockade in Cancer Therapy

2015 • 2,381 citations

The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): A Completed Reference Database of Lung Nodules on CT Scans

2011 • 2,237 citations

PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors

2003 • 2,224 citations

Lung Cancer: Epidemiology, Etiology, and Prevention

2011 • 2,202 citations

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers

2013 • 2,195 citations

Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

2019 • 2,100 citations

Reporting of Noninferiority and Equivalence Randomized Trials

2012 • 2,014 citations

Prognostic Factors for Overall Survival in Patients With Metastatic Renal Cell Carcinoma Treated With Vascular Endothelial Growth Factor–Targeted Agents: Results From a Large, Multicenter Study

2009 • 1,957 citations

Tobacco Smoke Carcinogens and Lung Cancer

1999 • 1,927 citations

Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study

2011 • 1,856 citations

Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK

2009 • 1,805 citations

Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies

2004 • 1,639 citations

Survival of Patients with Stage I Lung Cancer Detected on CT Screening

2006 • 1,623 citations

21st-Century Hazards of Smoking and Benefits of Cessation in the United States

2013 • 1,579 citations

Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs

2014 • 1,552 citations

Biomarker Analyses and Final Overall Survival Results From a Phase III, Randomized, Open-Label, First-Line Study of Gefitinib Versus Carboplatin/Paclitaxel in Clinically Selected Patients With Advanced Non–Small-Cell Lung Cancer in Asia (IPASS)

2011 • 1,492 citations

ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers

2012 • 1,480 citations

Interferon-Alfa as a Comparative Treatment for Clinical Trials of New Therapies Against Advanced Renal Cell Carcinoma

2002 • 1,471 citations

Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials

2015 • 1,466 citations

Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies

2000 • 1,391 citations

Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial

2015 • 1,354 citations

Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial

2009 • 1,294 citations

A cancer family syndrome in twenty-four kindreds.

1988 • 1,274 citations

Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology

2013 • 1,229 citations

Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study

2012 • 1,220 citations

Long-Term Efficacy of Zoledronic Acid for the Prevention of Skeletal Complications in Patients With Metastatic Hormone-Refractory Prostate Cancer

2004 • 1,174 citations

NCCN Task Force Report: Update on the Management of Patients with Gastrointestinal Stromal Tumors

2010 • 1,159 citations

Benefits and Harms of CT Screening for Lung Cancer

2012 • 1,157 citations

Overall Survival and Long-Term Safety of Nivolumab (Anti–Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer

2015 • 1,128 citations

Risk stratification of patients diagnosed with gastrointestinal stromal tumor

2008 • 1,101 citations

A review of human carcinogens—Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish

2009 • 1,043 citations

50-Year Trends in Smoking-Related Mortality in the United States

2013 • 1,036 citations

Results of Initial Low-Dose Computed Tomographic Screening for Lung Cancer

2013 • 986 citations

MicroRNAs accurately identify cancer tissue origin

2008 • 975 citations

Long-Term Results From a Randomized Phase II Trial of Standard- Versus Higher-Dose Imatinib Mesylate for Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing KIT

2008 • 958 citations

Recommendations for the Management of Subsolid Pulmonary Nodules Detected at CT: A Statement from the Fleischner Society

2012 • 952 citations

Annual Report to the Nation on the Status of Cancer, 1975–2005, Featuring Trends in Lung Cancer, Tobacco Use, and Tobacco Control

2008 • 938 citations

One vs Three Years of Adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor

2012 • 907 citations

Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis

2011 • 877 citations

KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours

2006 • 862 citations

A review of human carcinogens—Part C: metals, arsenic, dusts, and fibres

2009 • 850 citations

Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma

2018 • 810 citations

A review of human carcinogens—Part F: Chemical agents and related occupations

2009 • 805 citations

Randomized Phase III Trial of High-Dose Interleukin-2 Versus Subcutaneous Interleukin-2 and Interferon in Patients With Metastatic Renal Cell Carcinoma

2004 • 801 citations

Pseudoprogression and Immune-Related Response in Solid Tumors

2015 • 792 citations

The International Epidemiology of Lung Cancer: Geographical Distribution and Secular Trends

2008 • 780 citations

Randomized Study of High-Dose and Low-Dose Interleukin-2 in Patients With Metastatic Renal Cancer

2003 • 778 citations

Familial Adenomatous Polyposis

2006 • 726 citations

Cancers with increasing incidence trends in the United States: 1999 through 2008

2012 • 710 citations

Management of non-small-cell lung cancer: recent developments

2013 • 699 citations

American Cancer Society lung cancer screening guidelines

2013 • 697 citations

Nivolumab plus ipilimumab versus sunitinib in first-line treatment for advanced renal cell carcinoma: extended follow-up of efficacy and safety results from a randomised, controlled, phase 3 trial

2019 • 678 citations

Epidemiology of Lung Cancer

2013 • 667 citations

Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors

2003 • 665 citations

Unique Clinicopathologic Features Characterize ALK-Rearranged Lung Adenocarcinoma in the Western Population

2009 • 665 citations

Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial

2017 • 659 citations

Epidemiology of Lung Cancer

2007 • 621 citations

Variations in Lung Cancer Risk Among Smokers

2003 • 610 citations

Interferon-Alfa as a Comparative Treatment for Clinical Trials of New Therapies Against Advanced Renal Cell Carcinoma

2002 • 603 citations

Correlation of Kinase Genotype and Clinical Outcome in the North American Intergroup Phase III Trial of Imatinib Mesylate for Treatment of Advanced Gastrointestinal Stromal Tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group

2008 • 596 citations

Diagnostic and therapeutic management of cancer of an unknown primary

2003 • 591 citations

The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups

2012 • 582 citations

Analysis of Epidermal Growth Factor Receptor Gene Mutation in Patients with Non–Small Cell Lung Cancer and Acquired Resistance to Gefitinib

2006 • 579 citations

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

2010 • 573 citations

EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications

2011 • 568 citations

Molecular Epidemiology of EGFR and KRAS Mutations in 3,026 Lung Adenocarcinomas: Higher Susceptibility of Women to Smoking-Related KRAS-Mutant Cancers

2012 • 552 citations

Initial Hormonal Management of Androgen-Sensitive Metastatic, Recurrent, or Progressive Prostate Cancer: 2007 Update of an American Society of Clinical Oncology Practice Guideline

2007 • 550 citations

Lung Cancer Following Chemotherapy and Radiotherapy for Hodgkin's Disease

2002 • 548 citations

A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer

2011 • 519 citations

Familial adenomatous polyposis

2009 • 519 citations

Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

2014 • 513 citations

Intermittent versus Continuous Androgen Deprivation in Prostate Cancer

2013 • 512 citations

Cost-Effectiveness of CT Screening in the National Lung Screening Trial

2014 • 506 citations

Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer

2013 • 503 citations

Results of the Two Incidence Screenings in the National Lung Screening Trial

2013 • 499 citations

Desmoid Tumor: Prognostic Factors and Outcome After Surgery, Radiation Therapy, or Combined Surgery and Radiation Therapy

1999 • 491 citations

Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis

2009 • 490 citations

Risk‐based selection from the general population in a screening trial: Selection criteria, recruitment and power for the Dutch‐Belgian randomised lung cancer multi‐slice CT screening trial (NELSON)

2006 • 482 citations

Genotyping and Genomic Profiling of Non–Small-Cell Lung Cancer: Implications for Current and Future Therapies

2013 • 475 citations

Clinical and molecular genetics of patients with the Carney–Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD

2007 • 466 citations

Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma

2000 • 464 citations

Estimating Effective Dose for CT Using Dose–Length Product Compared With Using Organ Doses: Consequences of Adopting International Commission on Radiological Protection Publication 103 or Dual-Energy Scanning

2010 • 459 citations

Lung cancer probability in patients with CT-detected pulmonary nodules: a prespecified analysis of data from the NELSON trial of low-dose CT screening

2014 • 453 citations

Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype.

2003 • 453 citations

Intermittent Androgen Suppression for Rising PSA Level after Radiotherapy

2012 • 451 citations

Response to Cabozantinib in Patients with RET Fusion-Positive Lung Adenocarcinomas

2013 • 448 citations

The LLP risk model: an individual risk prediction model for lung cancer

2007 • 441 citations

A randomised, double-blind phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: Final overall survival results and safety update

2013 • 426 citations

A Novel, Highly Sensitive Antibody Allows for the Routine Detection ofALK-Rearranged Lung Adenocarcinomas by Standard Immunohistochemistry

2010 • 423 citations

The Danish Randomized Lung Cancer CT Screening Trial—Overall Design and Results of the Prevalence Round

2009 • 418 citations

Androgen Deprivation Therapy (ADT) Plus Docetaxel Versus ADT Alone in Metastatic Non castrate Prostate Cancer: Impact of Metastatic Burden and Long-term Survival Analysis of the Randomized Phase 3 GETUG-AFU15 Trial

2015 • 413 citations

Tumors associated with p53 germline mutations: a synopsis of 91 families.

1997 • 409 citations

EGFR Exon 20 Insertion Mutations in Lung Adenocarcinomas: Prevalence, Molecular Heterogeneity, and Clinicopathologic Characteristics

2013 • 408 citations

Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): Early results of RTOG 0132/ACRIN 6665

2008 • 404 citations

Histological Subtype is an Independent Predictor of Outcome for Patients With Renal Cell Carcinoma

2010 • 403 citations

Diagnosis of Lung Cancer in Small Biopsies and Cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification

2012 • 398 citations

Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial

2013 • 396 citations

A Risk Model for Prediction of Lung Cancer

2007 • 395 citations

Intraoperative Radiotherapy in Retroperitoneal Sarcomas

1993 • 393 citations

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

2010 • 392 citations

Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial

2013 • 390 citations

Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors (GIST): A meta-analyis based on 1,640 patients (pts)

2007 • 385 citations

Managing Immune Checkpoint-Blocking Antibody Side Effects

2015 • 384 citations

Screening for Lung Cancer

2013 • 384 citations

CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT

2012 • 384 citations

Effects of intermittent androgen suppression on androgen-dependent tumors. Apoptosis and serum prostate-specific antigen

1993 • 380 citations

Update onEpidermal Growth Factor ReceptorMutations in Non–Small Cell Lung Cancer

2006 • 359 citations

Desmoid-Type Fibromatosis: A Front-Line Conservative Approach to Select Patients for Surgical Treatment

2009 • 346 citations

Desmoid tumours in familial adenomatous polyposis.

1994 • 345 citations

Familial paraganglioma and gastric stromal sarcoma: A new syndrome distinct from the Carney triad

2002 • 345 citations

Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers.

2001 • 344 citations

Molecular Gene Expression Profiling to Predict the Tissue of Origin and Direct Site-Specific Therapy in Patients With Carcinoma of Unknown Primary Site: A Prospective Trial of the Sarah Cannon Research Institute

2012 • 341 citations

Optimizing the Detection of Lung Cancer Patients Harboring Anaplastic Lymphoma Kinase (ALK) Gene Rearrangements Potentially Suitable for ALK Inhibitor Treatment

2010 • 336 citations

Crizotinib Therapy for Advanced Lung Adenocarcinoma and a ROS1 Rearrangement: Results From the EUROS1 Cohort

2015 • 335 citations

The Desmoid Tumor

1989 • 332 citations

Prognostic factors associated with long-term survival for retroperitoneal sarcoma: implications for management.

1997 • 319 citations

The global burden of disease due to occupational carcinogens

2005 • 315 citations

Emerging Paradigms in the Development of Resistance to Tyrosine Kinase Inhibitors in Lung Cancer

2013 • 313 citations

Natural History and Molecular Characteristics of Lung Cancers Harboring EGFR Exon 20 Insertions

2013 • 305 citations

Pretreatment EGFR T790M Mutation and BRCA1 mRNA Expression in Erlotinib-Treated Advanced Non–Small-Cell Lung Cancer Patients with EGFR Mutations

2011 • 302 citations

Biomarkers of Response to Epidermal Growth Factor Receptor Inhibitors in Non–Small-Cell Lung Cancer Working Group: Standardization for Use in the Clinical Trial Setting

2008 • 302 citations

Lung Cancer Epidemiology, Risk Factors, and Prevention

2012 • 294 citations

Systematic review of the relationship between family history and lung cancer risk

2005 • 292 citations

Combined Surgical and Molecular Therapy

2006 • 290 citations

Lung Cancer Risk Prediction: Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Models and Validation

2011 • 289 citations

Five-year Lung Cancer Screening Experience: CT Appearance, Growth Rate, Location, and Histologic Features of 61 Lung Cancers

2007 • 283 citations

Lung Cancer Death Rates in Lifelong Nonsmokers

2006 • 283 citations

Outcome and prognosis in retroperitoneal soft tissue sarcoma

1994 • 279 citations

Molecular Testing for Selection of Patients With Lung Cancer for Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Guideline

2014 • 271 citations

Extra-abdominal primary fibromatosis: Aggressive management could be avoided in a subgroup of patients

2007 • 267 citations

Incidence of EGFR Exon 19 Deletions and L858R in Tumor Specimens From Men and Cigarette Smokers With Lung Adenocarcinomas

2011 • 264 citations

Significant antitumor effect from bone-seeking, alpha-particle-emitting (223)Ra demonstrated in an experimental skeletal metastases model.

2002 • 260 citations

Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness

2005 • 259 citations

Pulmonary Nodules on Multi–Detector Row CT Scans: Performance Comparison of Radiologists and Computer-aided Detection

2005 • 258 citations

Optimization of Patient Selection for Gefitinib in Non–Small Cell Lung Cancer by Combined Analysis of Epidermal Growth Factor Receptor Mutation, K-ras Mutation, and Akt Phosphorylation

2006 • 257 citations

Radiation Dose Reduction in Chest CT: A Review

2008 • 251 citations

Long-Term Results of Two Prospective Trials of Preoperative External Beam Radiotherapy for Localized Intermediate- or High-Grade Retroperitoneal Soft Tissue Sarcoma

2006 • 250 citations

Activity of Sorafenib against Desmoid Tumor/Deep Fibromatosis

2011 • 247 citations

Natural History of Pure Ground-Glass Opacity Lung Nodules Detected by Low-Dose CT Scan

2013 • 242 citations

Characteristics of Lung Cancers Detected by Computer Tomography Screening in the Randomized NELSON Trial

2013 • 241 citations

The epidemiology of soft tissue sarcoma.

1997 • 238 citations

Surgery and Imatinib in the Management of GIST: Emerging Approaches to Adjuvant and Neoadjuvant Therapy

2004 • 238 citations

Molecular Profiling of Carcinoma of Unknown Primary and Correlation With Clinical Evaluation

2008 • 236 citations

Releasing the Brakes on Cancer Immunotherapy

2015 • 233 citations

Targeting of osseous sites with alpha-emitting 223Ra: comparison with the beta-emitter 89Sr in mice.

2003 • 232 citations

Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men

2015 • 230 citations

Performance of ACR Lung-RADS in a Clinical CT Lung Screening Program

2014 • 228 citations

2nd ESMO Consensus Conference on Lung Cancer: non-small-cell lung cancer first-line/second and further lines of treatment in advanced disease

2014 • 228 citations

Radiopharmaceutical therapy for palliation of bone pain from osseous metastases.

2004 • 225 citations

Long-term results of intraoperative electron beam radiotherapy for primary and recurrent retroperitoneal soft tissue sarcoma

2001 • 224 citations

KRAS Mutation: Should We Test for It, and Does It Matter?

2013 • 223 citations

Endobronchial Ultrasound-Driven Biopsy in the Diagnosis of Peripheral Lung Lesions

2005 • 222 citations

Recent Clinical Advances in Lung Cancer Management

2014 • 216 citations

The Pittsburgh Lung Screening Study (PLuSS)

2008 • 216 citations

Risk of Soft Tissue Sarcomas by Individual Subtype in Survivors of Hereditary Retinoblastoma

2007 • 216 citations

INDEPENDENT VALIDATION OF THE 2002 AMERICAN JOINT COMMITTEE ON CANCER PRIMARY TUMOR CLASSIFICATION FOR RENAL CELL CARCINOMA USING A LARGE, SINGLE INSTITUTION COHORT

2005 • 215 citations

Detection of pulmonary nodules by multislice computed tomography: improved detection rate with reduced slice thickness

2003 • 214 citations

Impact of Lung Cancer Screening Results on Smoking Cessation

2014 • 209 citations

EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations

2012 • 209 citations

Immunohistochemistry for SDHB Divides Gastrointestinal Stromal Tumors (GISTs) into 2 Distinct Types

2010 • 206 citations

Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers

2011 • 204 citations

SDHB immunohistochemistry: a useful tool in the diagnosis of Carney–Stratakis and Carney triad gastrointestinal stromal tumors

2010 • 203 citations

NELSON lung cancer screening study

2011 • 203 citations

Pathologic Evaluation of Unknown Primary Cancer

2009 • 202 citations

Initial results of a trial of preoperative external-beam radiation therapy and postoperative brachytherapy for retroperitoneal sarcoma

2002 • 202 citations

Definition of a Positive Test Result in Computed Tomography Screening for Lung Cancer

2013 • 198 citations

Update in the Evaluation of the Solitary Pulmonary Nodule

2014 • 198 citations

A nation‐wide study comparing sporadic and familial adenomatous polyposis‐related desmoid‐type fibromatoses

2010 • 197 citations

Lung cancer screening as a teachable moment for smoking cessation

2006 • 191 citations

Multicenter Validation of a 1,550-Gene Expression Profile for Identification of Tumor Tissue of Origin

2009 • 191 citations

Treating Smokers in the Health Care Setting

2011 • 191 citations

High-dose-rate intraoperative radiation therapy (HDR-IORT) for retroperitoneal sarcomas

2000 • 189 citations

Molecular Classification of Human Cancers Using a 92‐Gene Real-Time Quantitative Polymerase Chain Reaction Assay

2006 • 189 citations

Gene Expression Profiling to Identify the Histogenetic Origin of Metastatic Adenocarcinomas of Unknown Primary

2008 • 184 citations

Preoperative intrathoracic lymph node staging in patients with non-small-cell lung cancer: accuracy of integrated positron emission tomography and computed tomography☆

2009 • 181 citations

Use of intraoperative electron beam radiotherapy in the management of retroperitoneal soft tissue sarcomas

2002 • 180 citations

Nivolumab: Targeting PD-1 to Bolster Antitumor Immunity

2015 • 179 citations

A Randomized, Phase II Study of Preoperative plus Postoperative Imatinib in GIST: Evidence of Rapid Radiographic Response and Temporal Induction of Tumor Cell Apoptosis

2008 • 175 citations

Preoperative imatinib mesylate for unresectable or locally advanced primary gastrointestinal stromal tumors (GIST)

2008 • 173 citations

Clinicopathologic and molecular correlations of necrosis in the primary tumor of patients with renal cell carcinoma

2005 • 172 citations

Impact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975–2000

2012 • 164 citations

Detection of ALK Gene Rearrangement in Non-small Cell Lung Cancer: A Comparison of Fluorescence In Situ Hybridization and Chromogenic In Situ Hybridization with Correlation of ALK Protein Expression

2011 • 161 citations

ACR–STR Practice Parameter for the Performance and Reporting of Lung Cancer Screening Thoracic Computed Tomography (CT)

2014 • 156 citations

An International Interpretation Study Using the ALK IHC Antibody D5F3 and a Sensitive Detection Kit Demonstrates High Concordance between ALK IHC and ALK FISH and between Evaluators

2014 • 155 citations

Chronic Obstructive Pulmonary Disease and Altered Risk of Lung Cancer in a Population-Based Case-Control Study

2009 • 153 citations

Phase I Trial of Preoperative Concurrent Doxorubicin and Radiation Therapy, Surgical Resection, and Intraoperative Electron-Beam Radiation Therapy for Patients With Localized Retroperitoneal Sarcoma

2003 • 152 citations

Strategies to Help a Smoker Who Is Struggling to Quit

2012 • 150 citations

A Second-Generation MicroRNA-Based Assay for Diagnosing Tumor Tissue Origin

2012 • 149 citations

REEVALUATION OF THE 1997 TNM CLASSIFICATION FOR RENAL CELL CARCINOMA: T1 AND T2 CUTOFF POINT AT 4.5 RATHER THAN 7 CM. BETTER CORRELATES WITH CLINICAL OUTCOME

2001 • 147 citations

Computed Tomography Screening for Lung Cancer: Has It Finally Arrived? Implications of the National Lung Screening Trial

2013 • 146 citations

Applying the National Lung Screening Trial eligibility criteria to the US population: what percent of the population and of incident lung cancers would be covered?

2012 • 143 citations

Androgen deprivation therapy: evidence‐based management of side effects

2013 • 139 citations

Pooled analysis of stereotactic ablative radiotherapy for primary renal cell carcinoma: A report from the International Radiosurgery Oncology Consortium for Kidney (IROCK)

2017 • 139 citations

Progression-free survival (PFS) from a phase I study of crizotinib (PF-02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC).

2011 • 138 citations

Retroperitoneal sarcomas: Combined-modality treatment approaches

2006 • 137 citations

Intermittent Versus Continuous Total Androgen Blockade in the Treatment of Patients with Advanced Hormone-Naive Prostate Cancer: Results of a Prospective Randomized Multicenter Trial

2002 • 137 citations

Preoperative radiation therapy with selective dose escalation to the margin at risk for retroperitoneal sarcoma

2006 • 135 citations

Renal cell cancer histological subtype distribution differs by race and sex

2014 • 133 citations

Hereditary Lung Cancer Syndrome Targets Never Smokers with Germline EGFR Gene T790M Mutations

2014 • 133 citations

Family History, Surgery, and APC Mutation Are Risk Factors for Desmoid Tumors in Familial Adenomatous Polyposis: An International Cohort Study

2011 • 132 citations

Lung Cancer Screening, Version 1.2015

2015 • 130 citations

Endobronchial Ultrasonography-Guided Transbronchial Needle Aspiration Increases the Diagnostic Yield of Peripheral Pulmonary Lesions

2008 • 129 citations

A critical analysis of treatment strategies in desmoid tumours: a review of a series of 106 cases

2008 • 126 citations

What Do You Mean, a Spot?

2013 • 125 citations

Molecular Profiling in Unknown Primary Cancer: Accuracy of Tissue of Origin Prediction

2010 • 124 citations

Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma

2008 • 122 citations

Neoadjuvant imatinib in patients with locally advanced non metastatic GIST in the prospective BFR14 trial

2011 • 122 citations

EGFRMutation Is a Better Predictor of Response to Tyrosine Kinase Inhibitors in Non–Small Cell Lung Carcinoma Than FISH, CISH, and Immunohistochemistry

2010 • 121 citations

ALK Status Testing in Non–Small Cell Lung Carcinoma

2013 • 120 citations

Effect of CAD on Radiologists' Detection of Lung Nodules on Thoracic CT Scans: Analysis of an Observer Performance Study by Nodule Size

2009 • 119 citations

Therapeutic Guidelines for the Treatment of Bone Metastasis: A Report from the American College of Radiology Appropriateness Criteria Expert Panel on Radiation Oncology

2009 • 119 citations

Crizotinib and Testing for ALK

2011 • 119 citations

Screening for Germline EGFR T790M Mutations Through Lung Cancer Genotyping

2012 • 118 citations

Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring <scp>BRAF</scp> mutations in the <scp>L</scp>ung <scp>C</scp>ancer <scp>M</scp>utation <scp>C</scp>onsortium

2014 • 118 citations

Prospective Gene Signature Study Using microRNA to Identify the Tissue of Origin in Patients with Carcinoma of Unknown Primary

2011 • 118 citations

Molecular Profiling Diagnosis in Unknown Primary Cancer: Accuracy and Ability to Complement Standard Pathology

2013 • 117 citations

Adjuvant Radiation Therapy for Resectable Retroperitoneal Soft Tissue Sarcoma

2005 • 117 citations

The UK Lung Screen (UKLS): Demographic Profile of First 88,897 Approaches Provides Recommendations for Population Screening

2014 • 115 citations

Desmoid Tumors – a Characterization of Patients Seen at Mayo Clinic 1976–1999

2006 • 113 citations

Cancer of Unknown Primary Site

2010 • 113 citations

Targeted therapy for non-small-cell lung cancer: past, present and future

2013 • 112 citations

CT Screening for Lung Cancer: Alternative Definitions of Positive Test Result Based on the National Lung Screening Trial and International Early Lung Cancer Action Program Databases

2014 • 111 citations

Pembrolizumab (pembro) plus axitinib (axi) versus sunitinib as first-line therapy for metastatic renal cell carcinoma (mRCC): Outcomes in the combined IMDC intermediate/poor risk and sarcomatoid subgroups of the phase 3 KEYNOTE-426 study.

2019 • 110 citations

Treatment of Prostate Cancer With Intermittent Versus Continuous Androgen Deprivation: A Systematic Review of Randomized Trials

2013 • 110 citations

EBUS-TBNA for the Clarification of PET Positive Intra-Thoracic Lymph Nodes—an International Multi-Centre Experience

2009 • 108 citations

The Introduction of Systematic Genomic Testing for Patients with Non–Small-Cell Lung Cancer

2012 • 108 citations

Opportunistic infections in patients treated with immunotherapy for cancer

2014 • 105 citations

Dramatic Response Induced by Vemurafenib in a BRAF V600E-Mutated Lung Adenocarcinoma

2013 • 105 citations

A Quantitative Reverse Transcriptase-Polymerase Chain Reaction Assay to Identify Metastatic Carcinoma Tissue of Origin

2006 • 104 citations

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2002 • 99 citations

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2011 • 95 citations

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2007 • 93 citations

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2005 • 90 citations

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2009 • 81 citations

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NCCN Non-Small-Cell Lung Cancer Practice Guidelines. The National Comprehensive Cancer Network.

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