Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

1998 • 4,380 citations

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

2002 • 4,254 citations

Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial

2006 • 2,500 citations

PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors

2003 • 2,224 citations

Biology of Gastrointestinal Stromal Tumors

2004 • 1,190 citations

Mutations in SDHC cause autosomal dominant paraganglioma, type 3

2000 • 877 citations

Primary and Secondary Kinase Genotypes Correlate With the Biological and Clinical Activity of Sunitinib in Imatinib-Resistant Gastrointestinal Stromal Tumor

2008 • 726 citations

SDH5 , a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

2009 • 686 citations

Genetic Testing in Pheochromocytoma or Functional Paraganglioma

2005 • 657 citations

SDHA is a tumor suppressor gene causing paraganglioma

2010 • 629 citations

Mitochondrial tumour suppressors: a genetic and biochemical update

2005 • 612 citations

Correlation of Kinase Genotype and Clinical Outcome in the North American Intergroup Phase III Trial of Imatinib Mesylate for Treatment of Advanced Gastrointestinal Stromal Tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group

2008 • 596 citations

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

2009 • 506 citations

Clinical and molecular genetics of patients with the Carney–Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD

2007 • 466 citations

Heterogeneity of kinase inhibitor resistance mechanisms in GIST

2008 • 435 citations

A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

2005 • 425 citations

The R22X Mutation of the SDHD Gene in Hereditary Paraganglioma Abolishes the Enzymatic Activity of Complex II in the Mitochondrial Respiratory Chain and Activates the Hypoxia Pathway

2001 • 356 citations

The Succinate Dehydrogenase Genetic Testing in a Large Prospective Series of Patients with Paragangliomas

2009 • 356 citations

Familial paraganglioma and gastric stromal sarcoma: A new syndrome distinct from the Carney triad

2002 • 345 citations

Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)

2004 • 331 citations

Predictors and Prevalence of Paraganglioma Syndrome Associated With Mutations of the <EMPH TYPE="ITAL">SDHC</EMPH> Gene

2005 • 330 citations

Gastrointestinal Stromal Tumors of the Stomach in Children and Young Adults

2005 • 303 citations

Clinical Presentations, Biochemical Phenotypes, and Genotype-Phenotype Correlations in Patients withSuccinate Dehydrogenase Subunit B-Associated Pheochromocytomas and Paragangliomas

2007 • 279 citations

Monoclonal Antibody DOG1.1 Shows Higher Sensitivity Than KIT in the Diagnosis of Gastrointestinal Stromal Tumors, Including Unusual Subtypes

2009 • 276 citations

SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

2010 • 259 citations

Molecular Characterization of Pediatric Gastrointestinal Stromal Tumors

2008 • 245 citations

Gastrointestinal Stromal Tumors

2013 • 220 citations

Functional Consequences of aSDHBGene Mutation in an Apparently Sporadic Pheochromocytoma

2002 • 210 citations

Germline Mutations and Variants in the Succinate Dehydrogenase Genes in Cowden and Cowden-like Syndromes

2008 • 210 citations

Immunohistochemistry for SDHB Divides Gastrointestinal Stromal Tumors (GISTs) into 2 Distinct Types

2010 • 206 citations

The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency

2005 • 183 citations

Nearly all hereditary paragangliomas in The Netherlands are caused by two founder mutations in the SDHD gene

2001 • 166 citations

Pediatric KIT–Wild-Type and Platelet-Derived Growth Factor Receptor α–Wild-Type Gastrointestinal Stromal Tumors Share KIT Activation but not Mechanisms of Genetic Progression with Adult Gastrointestinal Stromal Tumors

2007 • 162 citations

Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib

2009 • 152 citations

Should Patients with Apparently Sporadic Pheochromocytomas or Paragangliomas be Screened for Hereditary Syndromes?

2006 • 137 citations

Isocitrate Dehydrogenase Mutations Are Rare in Pheochromocytomas and Paragangliomas

2009 • 125 citations

Outcome of Metastatic GIST in the Era before Tyrosine Kinase Inhibitors

2006 • 115 citations

Three spectrophotometric assays for the measurement of the five respiratory chain complexes in minuscule biological samples

2006 • 96 citations

Autosomal dominant malignant and catecholamine-producing paraganglioma caused by a splice donor site mutation in SDHC

2003 • 75 citations

Genetic Analyses of Apparently Sporadic Pheochromocytomas

2006 • 31 citations

Mutations of the Metabolic GenesIDH1,IDH2, andSDHAF2Are Not Major Determinants of the Pseudohypoxic Phenotype of Sporadic Pheochromocytomas and Paragangliomas

2010 • 28 citations

SDHB mutation analysis in familial and sporadic phaeochromocytoma identifies a novel mutation

2002 • 19 citations