Blinded Comparator Study of Immunohistochemical Analysis versus a 92-Gene Cancer Classifier in the Diagnosis of the Primary Site in Metastatic Tumors

A Coefficient of Agreement for Nominal Scales

1960 • 37,524 citations

Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer

2004 • 10,779 citations

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

2011 • 7,390 citations

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

1997 • 5,683 citations

Erlotinib in Previously Treated Non–Small-Cell Lung Cancer

2005 • 5,383 citations

Note on the sampling error of the difference between correlated proportions or percentages

1947 • 3,814 citations

Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non–Small-Cell Lung Cancer Previously Treated With Chemotherapy

2004 • 2,376 citations

American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS Gene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti–Epidermal Growth Factor Receptor Monoclonal Antibody Therapy

2009 • 1,144 citations

Cancer of unknown primary site

2012 • 527 citations

American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients With Advanced Non–Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy

2011 • 489 citations

Molecular Gene Expression Profiling to Predict the Tissue of Origin and Direct Site-Specific Therapy in Patients With Carcinoma of Unknown Primary Site: A Prospective Trial of the Sarah Cannon Research Institute

2012 • 341 citations

Markers of Adenocarcinoma Characteristic of the Site of Origin: Development of a Diagnostic Algorithm

2005 • 326 citations

PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors.

2010 • 281 citations

Panels of Immunohistochemical Markers Help Determine Primary Sites of Metastatic Adenocarcinoma

2007 • 203 citations

Molecular Classification of Human Cancers Using a 92-Gene Real-Time Quantitative Polymerase Chain Reaction Assay

2006 • 197 citations

Molecular Classification of Human Cancers Using a 92‐Gene Real-Time Quantitative Polymerase Chain Reaction Assay

2006 • 189 citations

Panels of immunohistochemical markers help determine primary sites of metastatic adenocarcinoma.

2007 • 179 citations

Immunohistochemical Identification of Tumor Markers in Metastatic Adenocarcinoma:A Diagnostic Adjunct in the Determination of Primary Site

1997 • 172 citations

Sample Size for Testing Differences in Proportions for the Paired-Sample Design

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Immunohistologic evaluation of metastatic carcinomas of unknown origin: an algorithmic approach.

2000 • 151 citations

Validation of a microRNA-based qRT-PCR test for accurate identification of tumor tissue origin

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Validation and Reproducibility of a Microarray-Based Gene Expression Test for Tumor Identification in Formalin-Fixed, Paraffin-Embedded Specimens

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Crizotinib and Testing for ALK

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Trastuzumab combined with chemotherapy for the treatment of HER2-positive metastatic breast cancer: Pivotal trial data

2001 • 101 citations

Performance and Clinical Evaluation of the 92-Gene Real-Time PCR Assay for Tumor Classification

2011 • 100 citations

Determining Tissue of Origin for Metastatic Cancers

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Multisite Validation Study to Determine Performance Characteristics of a 92-Gene Molecular Cancer Classifier

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Use of tumour marker immunoreactivity to identify primary site of metastatic cancer.

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Molecular gene expression profiling to predict the tissue of origin and direct site-specific therapy in patients (pts) with carcinoma of unknown primary site (CUP): Results of a prospective Sarah Cannon Research Institute (SCRI) trial.

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