Calmodulin: a potential target for cancer chemotherapeutic agents.

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Calmodulin Plays a Pivotal Role in Cellular Regulation

1980 • 2,441 citations

Calmodulin—an intracellular calcium receptor

1980 • 964 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.

1979 • 724 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Identification of the Ca²⁺‐dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase

1978 • 619 citations

Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase.

1975 • 546 citations

Binding of trifluoperazine to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

1977 • 544 citations

Cyclic 3',5'-Nucleotide Phosphodiesterase

1971 • 531 citations

Calcium-induced exposure of a hydrophobic surface on calmodulin

1980 • 520 citations

Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells.

1982 • 516 citations

Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain

1970 • 491 citations

Modulator protein as a component of the myosin light chain kinase from chicken gizzard

1978 • 488 citations

Phosphodiesterase protein activator mimics red blood cell cytoplasmic activator of (Ca2+-Mg2+)ATPase

1977 • 483 citations

Discovery of A Ca²⁺‐and calmodulin‐dependent protein phosphatase

1982 • 476 citations

Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

1980 • 464 citations

Calmodulin and the cell cycle: Involvement in regulation of cell-cycle progression

1982 • 414 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

Partial purification of the Ca2+-Mg2+ ATPase activator from human erythrocytes: Its similarity to the activator of 3′:5′ — cyclic nucleotide phosphodiesterase

1977 • 395 citations

Mechanism by which psychotropic drugs inhibit adenosine cyclic 3',5'-monophosphate phosphodiesterase of brain.

1976 • 389 citations

Protein activator of cyclic 3′:5′-nucleotide phosphodiesterase of bovine or rat brain also activates its adenylate cyclase

1975 • 361 citations

Calmodulin. Development and application of a sensitive radioimmunoassay.

1979 • 350 citations

Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator".

1978 • 346 citations

Stimulation of Ca ²⁺ -dependent neurotransmitter release and presynaptic nerve terminal protein phosphorylation by calmodulin and a calmodulin-like protein isolated from synaptic vesicles

1979 • 346 citations

PHARMACOLOGICAL REGULATION OF CALMODULIN*

1980 • 341 citations

Activation of calmodulin by various metal cations as a function of ionic radius.

1984 • 336 citations

Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.

1980 • 335 citations

Identification of an activator protein for myosin light chain kinase as the Ca2+-dependent modulator protein.

1978 • 311 citations

Interaction of drugs with calmodulin

1982 • 306 citations

Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase

1984 • 296 citations

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. II. Substrate specificity and inhibition by various agents.

1982 • 290 citations

Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells.

1978 • 268 citations

Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships.

1982 • 259 citations

Calcium-dependent regulator of NAD kinase in higher plants

1978 • 254 citations

Interaction of the antihypertensive drug felodipine with calmodulin

1981 • 251 citations

Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors.

1983 • 250 citations

R 24 571: A potent inhibitor of calmodulin-activated enzymes

1981 • 241 citations

Changes in calmodulin and its mrna accompany reentry of quiescent (G0) cells into the cell cycle

1984 • 229 citations

Uptake and retention of adriamycin and daunorubicin by sensitive and anthracycline-resistant sublines of P388 leukemia

1978 • 212 citations

Quantitative Determinations of Calmodulin in the Supernatant and Particulate Fractions of Mammalian Tissues1

1982 • 209 citations

Specificity of the binding of trifluoperazine to the calcium-dependent activator of phosphodiesterase and to a series of other calcium-binding proteins

1978 • 207 citations

Agonist and antagonist properties of calmodulin fragments.

1984 • 198 citations

Ca2+-dependent high-affinity complex formation between calmodulin and melittin

1983 • 191 citations

Enhancement of sensitivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluoperazine.

1983 • 167 citations

Local anesthetics, mepacrine, and propranolol are antagonists of calmodulin.

1981 • 164 citations

Calmodulin stimulates DNA synthesis by rat liver cells

1980 • 164 citations

Interaction of calcium antagonists with cyclic AMP phosphodiesterases and calmodulin

1982 • 163 citations

Separation of multiple molecular forms of cyclic adenosine-3′,5′-monophosphate phosphodiesterase in rat cerebellum by polyacrylamide gel electrophoresis

1972 • 156 citations

Stimulation of the purified erythrocyte Ca2+-ATPase by tryptic fragments of calmodulin.

1984 • 151 citations

Calcium and calmodulin in cell growth and transformation

1984 • 145 citations

Characterization of tryptic fragments obtained from bovine brain protein modulator of cyclic nucleotide phosphodiesterase.

1977 • 142 citations

Phenothiazine antagonism of calmodulin: A structurally-nonspecific interaction

1981 • 141 citations

Calmodulin-dependent glycogen synthase kinase.

1980 • 138 citations

Different calcium requirements for proliferation of conditionally and unconditionally tumorigenic mouse cells.

1976 • 138 citations

Calmodulin and cell proliferation

1982 • 134 citations

Calmodulin-stimulated phosphorylation of 17 beta-estradiol receptor on tyrosine.

1984 • 134 citations

Calmodulin: an overview.

1982 • 133 citations

[17] Naphthalenesulfonamides as calmodulin antagonists

1983 • 133 citations

Structural and functional properties of calmodulin from the eukaryotic microorganism Dictyostelium discoideum

1984 • 129 citations

Inhibition of calcium-dependent regulator-stimulated phosphodiesterase activity by neuroleptic drugs is unrelated to their clinical efficacy.

1979 • 125 citations

Calcineurin is a calmodulin-dependent protein phosphatase

1982 • 121 citations

Calcium-dependent regulatory protein of cyclic nucleotide metabolism in normal and transformed chicken embryo fibroblasts.

1976 • 119 citations

Selective Alteration of the Activity of the Multiple Forms of Adenosine 3', 5'-Monophosphate Phosphodiesterase of Rat Cerebrum

1974 • 116 citations

Cellular resistance to daunomycin in Chinese hamster cells in vitro.

1971 • 113 citations

Damage of cellular functions by trifluoperazine, a calmodulin-specific drug

1980 • 111 citations

Can calmodulin inhibitors be used to probe calmodulin effects?

1981 • 110 citations

Properties and functions of calmodulin

1981 • 101 citations

Potentiation of Bleomycin Lethality by Anticalmodulin Drugs: A Role for Calmodulin in DNA Repair

1984 • 97 citations

Similarity in Ca2+-induced changes between troponin-C and protein activator of 3′:5′-cyclic nucleotide phosphodiesterase and their tryptic fragments

1977 • 96 citations

Interaction of local anesthetics with calmodulin

1981 • 96 citations

Binding of hormones and neuropeptides by calmodulin

1983 • 92 citations

Zinc inhibition of calmodulin: A proposed molecular mechanism of zinc action on cellular functions

1979 • 87 citations

Inhibition of growth of leukemic cells by inhibitors of calmodulin: Phenothiazines and melittin

1985 • 83 citations

An increase in calmodulin during growth of normal and cancerous liver in vivo

1981 • 82 citations

Activation of tryptophan 5-monooxygenase by calcium-dependent regulator protein

1979 • 81 citations

Inhibition by adriamycin of calmodulin-sensitive and phospholipid-sensitive calcium-dependent phosphorylation of endogenous proteins from heart

1981 • 80 citations

Stimulation of the Activity of Cyclic 3', 5'-Nucleotide Phosphodiesterase by Calcium Ion

1970 • 78 citations

Mechanisms and Pharmacological Implications of Altering Calmodulin Activity

1980 • 77 citations

Calmodulin triggers the resumption of meiosis in amphibian oocytes.

1981 • 77 citations

Occurrence of a low-molecular-weight calcium-binding protein in neoplastic liver.

1979 • 74 citations

Cations and calmodulin in normal and neoplastic cell growth regulation

1983 • 74 citations

Activation by a calcium-binding protein of guanylate cyclase in Tetrahymena pyriformis

1979 • 71 citations

Inhibition of human breast cancer colony formation by anticalmodulin agents: Trifluoperazine, W-7, and W-13

1983 • 70 citations

Interactions of basic polypeptides and proteins with calmodulin

1980 • 69 citations

The binding of calmodulin to myelin basic protein and histone H2B

1980 • 66 citations

High calcium content of pleiotropic drug-resistant P388 and K562 leukemia and Chinese hamster ovary cells.

1984 • 65 citations

Ultrastructural immunocytochemical localization of calmodulin in cultured cells.

1983 • 64 citations

Correlation between potency of calmodulin inhibitors and effects on cellular levels and cytotoxic activity of Doxorubicin (Adriamycin) in resistant P388 mouse leukemia cells

1984 • 63 citations

Differential effect of the calmodulin inhibitor trifluoperazine on cellular accumulation, retention, and cytotoxicity of anthracyclines in doxorubicin (adriamycin)-resistant P388 mouse leukemia cells.

1984 • 63 citations

Flow cytometric studies on modulation of cellular adriamycin retention by phenothiazines.

1985 • 63 citations

African trypanosomes contain calmodulin which is distinct from host calmodulin

1983 • 63 citations

Characteristics of the cytotoxic effects of the phenothiazine class of calmodulin antagonists

1985 • 62 citations

Calmodulin levels are grossly elevated in the psoriatic lesion

1983 • 62 citations

Inhibition by trifluoperazine of calmodulin-induced activation of ATPase activity of rat erythrocyte

1980 • 61 citations

Effects of Extracellular Calmodulin and Calmodulin Antagonists on B 16 Melanoma Cell Growth

1984 • 61 citations

Relationship between anti-diarrheal activity and binding to calmodulin

1982 • 59 citations

Multiple forms of cyclic 3′, 5′-AMP phosphodiesterase of rat cerebrum and cloned astrocytoma and neuroblastoma cells

1974 • 57 citations

Effects on calmodulin of bepridil, an antianginal agent.

1984 • 55 citations

Regional Distribution of Calmodulin Activity in Rat Brain

1985 • 54 citations

Biological activities of the peptides obtained by digestion of troponin C and calmodulin with thrombin

1981 • 53 citations

CALCIUM AND CAMP IN STIMULUS‐RESPONSE COUPLING*

1980 • 52 citations

Antitumor effect of a calmodulin antagonist on the growth of solid Sarcoma-180

1983 • 45 citations

Interaction of beta-endorphin and other opioid peptides with calmodulin.

1982 • 44 citations

Enhanced bleomycin-induced DNA damage and cytotoxicity with calmodulin antagonists.

1985 • 43 citations

Ca-calmodulin mediates the DNA-synthetic response of calcium-deprived liver cells to the tumor promoter TPA*1, *2

1982 • 42 citations

Potentiation of chemotherapeutic effect of vincristine in vincristine resistant tumor bearing mice by calmodulin inhibitor clomipramine.

1983 • 40 citations

Increased lethality of calmodulin antagonists and bleomycin to human bone marrow and bleomycin-resistant malignant cells.

1986 • 39 citations

Calcium and magnesium content of rat liver and Morris Hepatoma 5123 tc.

1967 • 38 citations

STIMULATION AND NUCLEAR BREAKDOWN IN THE NEREIS EGG

1937 • 37 citations

The interaction of dihydropyridine calcium channel blockers with calmodulin and calmodulin inhibitors.

1983 • 35 citations

Inhibition of calmodulin-activated cyclic nucleotide phosphodiesterase by triton x-100

1981 • 35 citations

Calcium: calmodulin and cancer.

1982 • 35 citations

Calcium effects on epidermal growth factor receptor‐mediated endocytosis in normal and SV40‐transformed human fibroblasts

1983 • 33 citations

Calmodulin antagonists and hormonal control of meiosis in starfish oocytes

1982 • 33 citations

THE EFFECTS OF TRIFLUOPERAZINE ON THE MACROPHAGE‐LIKE CELL LINE, J774*

1980 • 32 citations

Antagonism of calmodulin by local anesthetics. Inhibition of calmodulin-stimulated calcium transport of erythrocyte inside-out membrane vesicles.

1981 • 30 citations

Characteristics of the cyclic nucleotide phosphodiesterases of normal and leukemic lymphocytes

1977 • 29 citations

Effects of vinca alkaloids on calcium-calmodulin regulated cyclic adenosine 3',5'-monophosphate phosphodiesterase activity from brain

1981 • 28 citations

Interaction of alpha adrenergic antagonists with calmodulin

1984 • 25 citations

Isolation and characterization of des(Ala-Lys)calmodulin in porcine brain

1981 • 23 citations

Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma.

1980 • 21 citations

Cell cycle related phenothiazine effects on adriamycin transport

1984 • 20 citations

Phenothiazines cause a shift in the cAMP dose-response: Selection of resistant variants in a murine thymoma line

1984 • 19 citations

Cytotoxic Effect of Chlorpromazine and Its Interaction with Radiation on a Mouse Fibrosarcoma

1980 • 17 citations

Interaction of quaternary phenothiazine salts with calmodulin.

1984 • 16 citations

TREATMENT OF MYCOSIS FUNGOIDES WITH CYCLOPHOSPHAMIDE AND CHLORPROMAZINE

1968 • 16 citations

Inhibition of Glia maturation factor-induced mitogenesis in glioblasts by calmodulin antagonists

1983 • 14 citations

Effect of exogenous calmodulin on lymphocyte proliferation in normal subjects

1983 • 12 citations

Altered Calmodulin Activity in Fluphenazine‐Resistant Mutant Strains

1981 • 12 citations

Interaction of various peptides with calmodulin.

1984 • 11 citations

Modulation by phosphorylation of interaction between calmodulin and histones

1981 • 10 citations

Effect of nitrosoureas on calmodulin activity in vitro and in mouse intestine in vivo

1985 • 10 citations

Inhibition of growth of l1210 leukemic cells by inhibitors of cyclic nucleotide phosphodiesterase (pde) and calmodulin (cal). Abstr.

1983 • 9 citations

Cytotoxic & radiosensitizing effects of chlorpromazine hydrochloride in sarcoma 180A.

1980 • 9 citations

The fungicide chloraniformethan and the herbicide dichlofopmethyl affect calmodulin‐dependent cyclic nucleotide phosphodiesterase from bovine brain

1983 • 6 citations

Effect of perphenazine on growth and zinc‐65 uptake of the rat prostatic adenocarcinoma, R 3327

1982 • 6 citations

The effect of ring-substituted and quaternary chlorpromazine derivatives on the survival of the NK/Ly ascites tumor bearing mice.

1982 • 2 citations