Phosphatidylinositol-Derived Precursors and Signals

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400

1989 • 1,039 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.

1984 • 849 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+

1986 • 775 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

The Metabolism of Phosphoinositide-Derived Messenger Molecules

1986 • 717 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Isolation of a putative phospholipase c gene of drosophila, norpA, and its role in phototransduction

1988 • 665 citations

Solubilization, purification, and characterization of an inositol trisphosphate receptor.

1988 • 650 citations

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

1985 • 641 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

1982 • 541 citations

Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor

1989 • 531 citations

Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels

1987 • 529 citations

The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions

1981 • 518 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles

1989 • 512 citations

Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1981 • 492 citations

Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons

1989 • 431 citations

Diversity in the lipocortin/calpactin family

1988 • 376 citations

Inositol phosphates: synthesis and degradation.

1988 • 359 citations

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.

1988 • 359 citations

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

1989 • 342 citations

Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate

1984 • 337 citations

Signal transduction via phosphatidylcholine cycles

1989 • 314 citations

myo-inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors

1984 • 310 citations

Metabolism of the inositol phosphates produced upon receptor activation

1989 • 305 citations

An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

1988 • 292 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

Phospholipid-dependent Ca2+ binding by the 36-kDa tyrosine kinase substrate (calpactin) and its 33-kDa core.

1986 • 269 citations

Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils

1989 • 256 citations

Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.

1989 • 250 citations

Arachidonate metabolism in vascular disorders.

1983 • 243 citations

Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain

1989 • 238 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells.

1987 • 230 citations

Occurrence and extracellular actions of inositol pentakis- and hexakisphosphate in mammalian brain

1987 • 190 citations

Phosphorylation of middle T by pp60c-src: A switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis

1989 • 178 citations

Phosphoinositide turnover provides a link in stimulus—response coupling

1985 • 175 citations

The purification and properties of myo-inositol monophosphatase from bovine brain

1988 • 174 citations

A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity

1989 • 160 citations

cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons

1988 • 148 citations

Metabolism of <scp>d</scp>-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate

1987 • 147 citations

Mitogenesis in Response to PDGF and Bombesin Abolished by Microinjection of Antibody to PIP ₂

1988 • 146 citations

Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.

1989 • 145 citations

Phosphatidylinositol 3-Phosphate Is Present in Normal and Transformed Fibroblasts and Is Resistant to Hydrolysis by Bovine Brain Phospholipase C II

1989 • 137 citations

Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum

1987 • 132 citations

Inositol trisphosphate isomers, but not inositol 1,3,4,5-tetrakisphosphate, induce calcium influx in Xenopus laevis oocytes.

1988 • 129 citations

<scp>d</scp>-myoInositol 1:2-cyclic phosphate 2-phosphohydrolase

1972 • 128 citations

Phosphatidylinositol 3-Kinase and Its Novel Product, Phosphatidylinositol 3-phosphate, Are Present in Saccharomyces cerevisiae

1989 • 118 citations

Phosphorylation of rat liver nuclear envelopes. I. Characterization of in vitro protein phosphorylation.

1983 • 115 citations

Biosynthesis of myo-inositol in rat mammary gland. Isolation and properties of the enzymes

1974 • 115 citations

Cloning and expression of bovine brain inositol monophosphatase.

1990 • 107 citations

<scp>l</scp>-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells

1988 • 106 citations

Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts.

1986 • 105 citations

Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes.

1985 • 103 citations

Identity of Inositol 1,2-Cyclic Phosphate 2-Phosphohydrolase with Lipocortin III

1990 • 102 citations

Characterization and Purification of Membrane-associated Phosphatidylinositol-4-phosphate Kinase from Human Red Blood Cells

1989 • 96 citations

Identification and Isolation of a 75-kDa Inositol Polyphosphate-5-phosphatase from Human Platelets

1989 • 87 citations

Purification and Properties of myo-Inositol-1-Phosphatase from Rat Brain

1985 • 86 citations

Catalytic properties of inositol trisphosphate kinase: activation by Ca ²⁺ and calmodulin

1987 • 84 citations

Transformation by polyoma virus is drastically reduced by substitution of phenylalanine for tyrosine at residue 315 of middle-sized tumor antigen.

1984 • 83 citations

Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA-10 Leydig tumor cells.

1990 • 79 citations

<scp>l</scp>-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase

1988 • 77 citations

The Role of Phytic Acid in the Wheat Grain

1970 • 77 citations

Purification and characterization of a phosphatidylinositol kinase from A431 cells

1988 • 72 citations

Accumulation of inositol polyphosphate isomers in agonist-stimulated cerebral-cortex slices. Comparison with metabolic profiles in cell-free preparations

1989 • 69 citations

Fibroblasts Transformed with v- src Show Enhanced Formation of an Inositol Tetrakisphosphate

1989 • 67 citations

Inositol polyphosphates and intracellular calcium release

1989 • 66 citations

Calmodulin activates inositol 1,4,5-trisphosphate 3-kinase activity in pig aortic smooth muscle

1987 • 65 citations

Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes

1988 • 64 citations

Purification and characterization of a phosphatidylinositol 4-kinase from bovine uteri.

1988 • 62 citations

Membrane current responses to intracellular injections of inositol 1,3,4,5‐tetrakisphosphate and inositol 1,3,4‐trisphosphate in NG108‐15 hybrid cells

1986 • 60 citations

On the Metabolism of the Brain Phosphoinositide Complex

1962 • 60 citations

Inositol phospholipids activate plasma membrane ATPase in plants

1989 • 55 citations

Partial purification and some properties of rat brain inositol 1,4,5-trisphosphate 3-kinase

1988 • 54 citations

Phosphatidylinositol-4,5-bisphosphate may antecede diacylglycerol as activator of protein kinase C

1988 • 54 citations

Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor.

1987 • 53 citations

Studies on avian erythrocyte metabolism—II

1976 • 49 citations

Studies on Avian Erythrocyte Metabolism

1977 • 45 citations

Polyphosphoinositide metabolism in excitable membranes

1983 • 44 citations

The identification of a novel inositol lipid, phosphatidylinostiol trisphosphate (PIP3), in rat cerebrum using in vivo techniques

1989 • 42 citations

Formation of inositol phosphate isomers in GH3 pituitary tumour cells stimulated with thyrotropin-releasing hormone. Acute effects of lithium ions

1987 • 42 citations

Phosphatidylinositol-4-phosphate kinase from rat brain. Activation by polyamines and inhibition by phosphatidylinositol 4,5-bisphosphate

1986 • 37 citations

Rapid purification of inositol monophosphate phosphatase from beef brain

1988 • 37 citations

Phosphoinositide Metabolism and Hormone Action

1989 • 37 citations

Purification and characterization of phosphatidylinositol kinase from porcine liver microsomes

1988 • 37 citations

Characterization of inositol 1,3,4‐trisphosphate phosphorylation in rat liver

1988 • 35 citations

The isolation and characterization of inositol polyphosphate 4-phosphatase.

1990 • 35 citations

Molecular target sizes of inositol 1,4,5-trisphosphate receptors in liver and cerebellum

1990 • 34 citations

The quantitative spectrum of inositol phosphate metabolites in avian erythrocytes, analysed by proton n.m.r. and h.p.l.c. with direct isomer detection

1989 • 34 citations

Modification of myo-inositol monophosphatase by the arginine-specific reagent phenylglyoxal

1989 • 31 citations

Kinetic Analysis of A23187‐Mediated Polyphosphoinositide Breakdown in Rat Cortical Synaptosomes Suggests that Inositol Bisphosphate Does Not Arise Primarily by Degradation of Inositol Trisphosphate

1989 • 30 citations

The activation of protein kinase C by the polyphosphoinositides phosphatidylinositol 4,5‐diphosphate and phosphatidylinositol 4‐monophosphate

1987 • 26 citations

Stimulation by inositol trisphosphate and tetrakisphosphate of a protein phosphatase

1988 • 26 citations

Activation by calmodulin of inositol-1,4,5-trisphosphate 3-kinase in guinea pig peritoneal macrophages

1987 • 25 citations

The phosphorylation of purified phospholamban by cyclic AMP-dependent protein kinase is stimulated by phosphatidylinositol.

1987 • 24 citations

Purification and Characterization of Membrane-Bound Inositolpolyphosphate 5-Phosphatase1

1989 • 24 citations

Subcellular localization of the enzymes that dephosphorylate myo-inositol polyphosphates in human platelets

1988 • 17 citations

Immunochemical characterization of phosphatidylinositol 4-phosphate kinase from rat brain

1986 • 16 citations

Partial purification of inositol polyphosphate 1-phosphomonoesterase with characterization of its substrates and products by nuclear magnetic resonance spectroscopy

1989 • 15 citations

Evidence for at least four different inositol bisphosphatases in bovine brain

1989 • 14 citations

Studies on avian erythrocyte metabolism: Purification and properties of myo-inositol 1-phosphatase from chick erythrocytes

1981 • 11 citations