Mutation induction in γ-irradiated primary human bronchial epithelial cells and molecular analysis of the HPRT− mutants

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells.

1968 • 460 citations

Mammalian cell genetics. II. Chemical induction of specific locus mutations in Chinese hamster cells in vitro.

1968 • 376 citations

Automated DNA sequencing of the human HPRT locus

1990 • 357 citations

Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families

1990 • 328 citations

Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants

1982 • 295 citations

Clonal growth of normal adult human bronchial epithelial cells in a serum-free medium

1982 • 278 citations

Fine structure of the human hypoxanthine phosphoribosyltransferase gene.

1986 • 209 citations

The nature of mutants induced by ionising radiation in cultured hamster cells III. Molecular characterization of HPRT-deficient mutants induced by γ-rays or α-particles showing that the majority have deletions of all or part of the hprt gene

1986 • 207 citations

Transformation of Human Bronchial Epithelial Cells Transfected by Harvey ras Oncogene

1985 • 198 citations

IN VIVO SOMATIC MUTATIONS IN HUMANS: MEASUREMENT AND ANALYSIS

1990 • 197 citations

Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation

1988 • 188 citations

Ionizing radiation-induced mutagenesis

1988 • 158 citations

Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells

1989 • 141 citations

Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

1992 • 126 citations

Mutagenesis of cultured mammalian cells by X-irradiation and ultraviolet light

1970 • 110 citations

Ionizing radiation and genetic risks III. Nature of spontaneous and radiation-induced mutations in mammalian in vitro systems and mechanisms of induction of mutations by radiation

1991 • 103 citations

The Chinese hamster HPRT gene: Restriction map, sequence analysis, and multiplex PCR deletion screen

1991 • 89 citations

The induction of thioguanine-resistant mutants of Chinese hamster cells by γ-rays

1977 • 88 citations

Malignant transformatin of human bronchial epithelial cells by radon-simulated α-particles

1994 • 81 citations

Decreased Deletion Mutation in Radioadapted Human Lymphoblasts

1993 • 80 citations

Failla Memorial Lecture. Changing views of cellular radiosensitivity.

1994 • 79 citations

Molecular characterization of X-ray-induced mutations at the HPRT locus in plateau-phase Chinese hamster ovary cells

1990 • 66 citations

Molecular and biochemical analyses of spontaneous and X-ray induced mutants in human lymphoblastoid cells

1987 • 63 citations

Changing Views of Cellular Radiosensitivity

1994 • 55 citations

In vitro induction, expression and selection of thioguanine-resistant mutants with human T-lymphocytes

1990 • 53 citations

Localization of deletion breakpoints in radiation-induced mutants of the hprt gene in hamster cells

1990 • 52 citations

Southern-blot analyses of human T-lymphocyte mutants induced in vitro by γ-irradiation

1990 • 52 citations

Mapping large spontaneous deletion endpoints in the human HPRT gene

1988 • 52 citations

Molecular characterization of hprt mutants induced by low- and hgh-LET radiations in human cells

1990 • 48 citations

Southern Blot and Polymerase Chain Reaction Exon Analyses of HPRT - Mutations Induced by Radon and Radon Progeny

1994 • 47 citations

Large deletions are tolerated at the hprt locus of in vivo derived human T-lymphocytes

1992 • 45 citations

Mutation induction by charged particles of defined linear energy transfer

1988 • 43 citations

Molecular Characterization of¹²⁵I Decay and X-ray-induced HPRT Mutants in CHO Cells

1987 • 36 citations

GENETICS OF SOMATIC MAMMALIAN CELLS, VII. INDUCTION AND ISOLATION OF NUTRITIONAL MUTANTS IN CHINESE HAMSTER CELLS

1968 • 31 citations

Radiosensitivity and sublethal damage repair in human umbilical cord vein endothelial cells

1987 • 31 citations

Mutagenic and Transforming Effects of Soft-X-rays with Resonance Energy of Phosphorus K-absorption Edge

1992 • 29 citations

Spectrum of spontaneous HPRT mutations in TK6 human lymphoblasts

1993 • 27 citations

Mutations induced by γ-rays and fast neutrons in cultured mammalian cells

1982 • 24 citations

Expression dynamics of transforming phenotypes in X-irradiated Syrian golden hamster embryo cells

1991 • 21 citations

Radiation-induced deletion of chromosomal regions containing tumor suppressor genes in human bronchial epithelial cells

1993 • 21 citations

Molecular analysis of mutagenesis by high let radiation

1994 • 17 citations

The effects of hypoxia and cysteamine on X-ray mutagenesis in human cells. I. Dose response and Southern blot analysis of induced mutants.

1993 • 14 citations

A human bronchial epithelial cell strain with unusual in vitro growth potential which undergoes neoplastic transformation after SV40 T antigen gene transfection

1991 • 11 citations

The Effects of Hypoxia and Cysteamine on X-Ray Mutagenesis in Human Cells: I. Dose Response and Southern Blot Analysis of Induced Mutants

1993 • 9 citations