The Zinc Fingers of HIV Nucleocapsid Protein NCp7 Direct Interactions with the Viral Regulatory Protein Vpr

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

1995 • 885 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.

1991 • 644 citations

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

1995 • 518 citations

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection

1995 • 411 citations

First Glimpses at Structure-function Relationships of the Nucleocapsid Protein of Retroviruses

1995 • 402 citations

Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis

1993 • 368 citations

Human immunodeficiency virus vpr product is a virion-associated regulatory protein

1990 • 363 citations

Amino acid sequence homology in gag region of reverse transcribing elements and the coat protein gene of cauliflower mosaic virus

1986 • 305 citations

Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers.

1992 • 282 citations

Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions

1993 • 275 citations

Determination of the structure of the nucleocapsid protein NCp7 from the human immunodeficiency virus type 1 by 1H NMR.

1992 • 243 citations

Retroviral nucleocapsid domains mediate the specific recognition of genomic viral RNAs by chimeric Gag polyproteins during RNA packaging in vivo

1995 • 196 citations

Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycle

1993 • 177 citations

Interaction of Virion Protein Vpr of Human Immunodeficiency Virus Type 1 with Cellular Transcription Factor Sp1 and trans-Activation of Viral Long Terminal Repeat

1995 • 176 citations

Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation

1995 • 176 citations

Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme

1996 • 173 citations

HIV-1, Vpr and the cell cycle

1996 • 173 citations

The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles

1995 • 164 citations

The glucocorticoid receptor type II complex is a target of the HIV-1 vpr gene product.

1995 • 163 citations

Fusion from without directed by human immunodeficiency virus particles

1994 • 153 citations

Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR

1994 • 140 citations

Nucleocapsid protein effects on the specificity of retrovirus RNA encapsidation

1995 • 136 citations

A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles

1995 • 136 citations

Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras.

1996 • 136 citations

Binding of Zinc Finger Protein ZPR1 to the Epidermal Growth Factor Receptor

1996 • 119 citations

A conserved LXXLF sequence is the major determinant in p6gag required for the incorporation of human immunodeficiency virus type 1 Vpr

1996 • 118 citations

The Human Immunodeficiency Virus Type 1 Vpr Transactivator: Cooperation with Promoter-bound Activator Domains and Binding to TFIIB

1996 • 117 citations

Zinc‐ and sequence‐dependent binding to nucleic acids by the N‐terminal zinc finger of the HIV‐1 nucleocapsid protein: NMR structure of the complex with the Psi‐site analog, dACGCC

1993 • 113 citations

Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particles

1994 • 113 citations

Immunological and Chemical Analysis of P6, the Carboxyl-Terminal Fragment of HIV P15

1987 • 104 citations

The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivity

1995 • 100 citations

Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization

1996 • 97 citations

Zinc Binding to the HIV-1 Nucleocapsid Protein: A Thermodynamic Investigation by Fluorescence Spectroscopy

1996 • 97 citations

1H NMR structure and biological studies of the His23 .fwdarw. Cys mutant nucleocapsid protein of HIV-1 indicate that the conformation of the first zinc finger is critical for virus infectivity

1994 • 93 citations

Biochemical mechanism of HIV-1 Vpr function. Oligomerization mediated by the N-terminal domain.

1994 • 83 citations

Binding of the HIV-1 Nucleocapsid Protein to the Primer tRNALys3, inVitro, Is Essentially Not Specific

1995 • 74 citations

Mutagenesis of the putative alpha-helical domain of the Vpr protein of human immunodeficiency virus type 1: effect on stability and virion incorporation.

1995 • 68 citations

Sequence requirements for encapsidation of deletion mutants and chimeras of human immunodeficiency virus type 1 Gag precursor into retrovirus-like particles

1995 • 61 citations

Solid phase synthesis of the retro viral nucleocapsid protein NCp10 of Moloney Murine Leukaemia virus and related “zinc‐fingers” in free SH forms

1990 • 58 citations

Direct activation of protein phosphatase‐2A₀ by HIV‐1 encoded protein complex NCp7:vpr

1997 • 49 citations

Three-dimensional 1H NMR structure of the nucleocapsid protein NCp10 of Moloney murine leukemia virus

1994 • 36 citations

Two short basic sequences surrounding the zinc finger of nucleocapsid protein NCp10 of Moloney murine leukemia virus are critical for RNA annealing activity

1993 • 35 citations

Development of a novel anti-HIV-1 agent from within: Effect of chimeric Vpr-containing protease cleavage site residues on virus replication

1997 • 34 citations

The Vpr Protein of Human Immunodeficiency Virus Type 1 Binds to Nucleocapsid Protein p7in Vitro

1996 • 30 citations

Sequence‐Specific Resonance Assignments of the ¹H‐NMR Spectra and Structural Characterization in Solution of the HIV‐1 Transframe Protein p6*

1996 • 29 citations

Evidence for Direct Association of Vpr and Matrix Protein p17 within the HIV-1 Virion

1996 • 26 citations

Monoclonal Antibody-Mediated Inhibition of RNA Binding and Annealing Activities of HIV Type 1 Nucleocapsid Protein

1994 • 19 citations

A synthetic protein corresponding to the entire vpr gene product from the human immunodeficiency virus HIV‐1 is recognized by antibodies from HIV‐infected patients

1990 • 18 citations