Drug receptors and the inhibition of nerve cells

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1984 • 1,339 citations

The Physiology of Synapses

1964 • 1,239 citations

Cloning and expression of a rat D2 dopamine receptor cDNA

1988 • 1,125 citations

A G Protein Couples Serotonin and GABA _B Receptors to the Same Channels in Hippocampus

1986 • 870 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

Electrophysiological responses of serotoninergic dorsal raphe neurons to 5‐HT_1A and 5‐HT_1B agonists

1987 • 838 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

Cloning of Genomic and Complementary DNA from Shaker , a Putative Potassium Channel Gene from Drosophila

1987 • 721 citations

Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

1987 • 616 citations

Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta.

1987 • 611 citations

Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro.

1987 • 550 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins

1986 • 510 citations

Primary Structure and Biochemical Properties of an M ₂ Muscarinic Receptor

1987 • 510 citations

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 509 citations

Comparison of the action of baclofen with gamma‐aminobutyric acid on rat hippocampal pyramidal cells in vitro.

1985 • 488 citations

GABAB-receptor-activated K+ current in voltage-clamped CA3 pyramidal cells in hippocampal cultures.

1985 • 468 citations

Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin

1987 • 463 citations

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G _k

1987 • 441 citations

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

1988 • 440 citations

Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

1984 • 436 citations

The output of sympathetic transmitter from the spleen of the cat

1957 • 405 citations

Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance

1986 • 391 citations

On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.

1988 • 336 citations

A bicuculline‐resistant inhibitory post‐synaptic potential in rat hippocampal pyramidal cells in vitro.

1984 • 331 citations

The Rate of Action of Drugs on Cells

1937 • 319 citations

Molecular biology of the GABAA receptor: the receptor/channel superfamily

1987 • 303 citations

Enkephalin hyperpolarizes interneurones in the rat hippocampus.

1988 • 296 citations

Acetylcholine acts on m₂‐muscarinic receptors to excite rat locus coeruleus neurones

1985 • 266 citations

On the potassium conductance increased by opioids in rat locus coeruleus neurones.

1985 • 265 citations

Enkephalin opens potassium channels on mammalian central neurones

1982 • 264 citations

The Mode of Action of Drugs on Cells.

1933 • 258 citations

Ionic mechanisms and receptor properties underlying the responses of molluscan neurones to 5‐hydroxytryptamine

1974 • 256 citations

Inhibitory and excitatory effects of dopamine on Aplysia neurones

1972 • 254 citations

Adenosine-activated potassium conductance in cultured striatal neurons.

1985 • 253 citations

Opioid receptor types and membrane ion channels

1986 • 248 citations

Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurons in vitro

1988 • 248 citations

Zum Mechanismus der Membranwirkung des Acetylcholin an der Herzmuskelfaser

1958 • 247 citations

pA_x AND COMPETITIVE DRUG ANTAGONISM

1949 • 247 citations

Characterization of α2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones

1985 • 246 citations

The actions of noradrenaline on neurones of the rat substantia gelatinosa in vitro.

1984 • 244 citations

Pertussis toxin blocks the outward currents evoked by opiate and α2-agonists in locus coeruleus neurons

1986 • 241 citations

Substantia gelatinosa neurones hyperpolarized in vitro by enkephalin

1983 • 236 citations

Synaptic excitation and inhibition resulting from direct action of acetylcholine on two types of chemoreceptors on individual amphibian parasympathetic neurones

1977 • 233 citations

A CHOLINERGIC MECHANISM OF INHIBITORY SYNAPTIC TRANSMISSION IN A MOLLUSCAN NERVOUS SYSTEM

1962 • 232 citations

Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in Vitro

1980 • 229 citations

Ionic mechanism of a two‐component cholinergic inhibition in Aplysia neurones

1972 • 222 citations

On the negative inotropic effect in the cat's auricle

1953 • 202 citations

Expression of a Cloned Rat Brain Potassium Channel in Xenopus Oocytes

1989 • 202 citations

Noradrenaline‐mediated synaptic inhibition in rat locus coeruleus neurones.

1983 • 202 citations

Acetylcholine hyperpolarizes central neurones by acting on an M2 muscarinic receptor

1986 • 196 citations

Reconstitution of Somatostatin and Muscarinic Receptor Mediated Stimulation of K⁺Channels by Isolated G_KProtein in Clonal Rat Anterior Pituitary Cell Membranes *

1987 • 188 citations

Baclofen reduces post‐synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action.

1987 • 187 citations

Theories of drug antagonism.

1957 • 181 citations

Potassium channels expressed from rat brain cDNA have delayed rectifier properties

1988 • 173 citations

Inhibitory synaptic potentials resulting from alpha 2‐adrenoceptor activation in guinea‐pig submucous plexus neurones.

1985 • 170 citations

Inward rectification of resting and opiate-activated potassium currents in rat locus coeruleus neurons

1988 • 169 citations

Opiate-receptor interactions on single locus coeruleus neurones.

1984 • 166 citations

A single GTP-binding protein regulates K+-channels coupled with dopamine, histamine and acetylcholine receptors

1987 • 161 citations

Somatostatin induces an inward rectification in rat locus coeruleus neurones through a pertussis toxin‐sensitive mechanism.

1988 • 157 citations

Somatostatin increases an inwardly rectifying potassium conductance in guinea‐pig submucous plexus neurones.

1987 • 154 citations

Production of Membrane Potential Changes in the Frog's Heart by Inhibitory Nerve Impulses

1955 • 132 citations

Agonists at μ‐opioid, M₂ ‐muscarinic and GABA_B ‐receptors increase the same potassium conductance in rat lateral parabrachial neurones

1988 • 130 citations

Mechanisms of slow postsynaptic potentials

1981 • 124 citations

Opioid peptides with differential affinity for mu and delta receptors decrease sensory neuron calcium-dependent action potentials.

1983 • 117 citations

The action of adrenalin and ergotamine on the uterus of the rabbit

1926 • 116 citations

Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: effect of pertussis toxin and GTP gamma S on the late inhibitory postsynaptic potential of hippocampal CA3 neurons

1988 • 116 citations

Serotonin increases an anomalously rectifying K+ current in the Aplysia neuron R15.

1983 • 114 citations

Muscarinic inhibition of sympathetic C neurones in the bullfrog.

1983 • 109 citations

Mechanism of synaptic inhibition by noradrenaline acting at α ₂ -adrenoceptors

1988 • 107 citations

Non‐cholinergic excitatory transmission in inferior mesenteric ganglia of the guinea‐pig: possible mediation by substance P.

1982 • 107 citations

Multiple actions of 5‐hydroxytryptamine on myenteric neurones of the guinea‐pig ileum.

1980 • 105 citations

Single potassium channels opened by opioids in rat locus ceruleus neurons.

1989 • 103 citations

Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra

1987 • 101 citations

CLONIDINE ACTIVATES MEMBRANE POTASSIUM CONDUCTANCE IN MYENTERIC NEURONES

1981 • 91 citations

Hyperpolarization of the membrane potential caused by somatostatin in dissociated human pituitary adenoma cells that secrete growth hormone.

1986 • 89 citations

Opioids increase potassium conductance in submucous neurones of guinea‐pig caecum by activating δ‐receptors

1986 • 89 citations

Opiate activation of potassium conductance in myenteric neurons: inhibition by calcium ion

1982 • 85 citations

The Electrical Properties of Isolated Human Prolactin-Secreting Adenoma Cells and Their Modification by Dopamine*

1985 • 79 citations

Role of intracellular Mg2+ in the activation of muscarinic K+ channel in cardiac atrial cell membrane

1986 • 77 citations

Differential localization of 5-HT1 receptors on myenteric and submucosal neurons

1988 • 72 citations

The morphology and projections of dorsal horn spinocerebellar tract neurones in the cat.

1988 • 66 citations

Pertussis toxin pretreatment discriminates between pre- and postsynaptic actions of baclofen in rat dorsal raphe nucleus in vitro

1988 • 63 citations

The action of somatostatin on neurones of the myenteric plexus of the guinea‐pig ileum.

1980 • 59 citations

Potentiation of enkephalin action by peptidase inhibitors in rat locus ceruleus in vitro.

1987 • 59 citations

A potassium conductance contributes to the action of somatostatin-14 to suppress ACTH secretion

1988 • 56 citations

5-Hydroxytryptamine mediates inhibitory postsynaptic potentials in rat dorsal raphe neurons

1985 • 52 citations

Baclofen increases the potassium conductance of rat locus coeruleus neurons recorded in brain slices

1988 • 48 citations

Galanin‐induced hyperpolarization and decreased membrane excitability of neurones in mudpuppy cardiac ganglia.

1989 • 46 citations

Slow IPSP and the noradrenaline-induced inhibition of the cat sympathetic preganglionic neuron in vitro

1987 • 43 citations

Inhibitory synaptic potentials recorded from mammalian neurones prolonged by blockade of noradrenaline uptake.

1987 • 43 citations

A non‐adrenergic, non‐cholinergic slow inhibitory post‐synaptic potential in neurones of the guinea‐pig submucous plexus.

1987 • 39 citations

Electrophysiological responses to somatostatin of rat hypophysial cells in somatotroph‐enriched primary cultures.

1989 • 38 citations

Direct inhibition by opioid peptides of neurones located in the ventromedial nucleus of the guinea pig hypothalamus

1988 • 21 citations

Novel synaptic responses mediated by dopamine and γ-aminobutyric acid in neuroendocrine cells of the intermediate pituitary

1986 • 20 citations

Muscarinic excitation and inhibition of neurons in the submucous plexus of the guinea-pig caecum

1989 • 14 citations