Role of AT₁and AT₂receptors in regulation of MAPKs and MKP-1 by ANG II in adult cardiac myocytes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The MAPK signaling cascade

1995 • 3,300 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

1993 • 1,420 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.

1995 • 918 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

1993 • 713 citations

Angiotensin II type 2 receptor mediates programmed cell death.

1996 • 707 citations

The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

1995 • 688 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating.

1985 • 485 citations

The Mitogen-activated Protein Kinase Phosphatases PAC1, MKP-1, and MKP-2 Have Unique Substrate Specificities and Reduced Activity in Vivo toward the ERK2 sevenmaker Mutation

1996 • 434 citations

Angiotensin II and Other Hypertrophic Stimuli Mediated by G Protein–Coupled Receptors Activate Tyrosine Kinase, Mitogen-Activated Protein Kinase, and 90-kD S6 Kinase in Cardiac Myocytes

1995 • 412 citations

Endothelin-1 Is Involved in Mechanical Stress-induced Cardiomyocyte Hypertrophy

1996 • 400 citations

Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.

1994 • 387 citations

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases

1996 • 385 citations

MKP-3, a Novel Cytosolic Protein-tyrosine Phosphatase That Exemplifies a New Class of Mitogen-activated Protein Kinase Phosphatase

1996 • 350 citations

Blindsight in monkeys

1995 • 315 citations

Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

1996 • 275 citations

Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes.

1995 • 273 citations

Inhibitors of protein kinases and phosphatases

1994 • 268 citations

Interleukin-8. A mitogen and chemoattractant for vascular smooth muscle cells.

1994 • 259 citations

A Novel Mitogen-activated Protein Kinase Phosphatase. STRUCTURE, EXPRESSION, AND REGULATION

1995 • 233 citations

Growth Factors Proto-Oncogenes and Plasticity of the Cardiac Phenotype

1991 • 228 citations

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3

1996 • 227 citations

Rapamycin Selectively Inhibits Angiotensin II–Induced Increase in Protein Synthesis in Cardiac Myocytes In Vitro

1995 • 224 citations

Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts

1994 • 201 citations

Angiotensin II–Induced Growth Responses in Isolated Adult Rat Hearts

1995 • 200 citations

Intracardiac detection of angiotensinogen and renin: a localized renin-angiotensin system in neonatal rat heart

1992 • 197 citations

Interleukin-1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture.

1995 • 193 citations

Evidence for Two Catalytically Active Kinase Domains in pp90^rsk

1996 • 188 citations

Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein.

1994 • 182 citations

Mitogen-activated Protein (MAP) Kinase Is Regulated by the MAP Kinase Phosphatase (MKP-1) in Vascular Smooth Muscle Cells

1995 • 177 citations

Dissociation of p44 and p42 Mitogen-activated Protein Kinase Activation from Receptor-induced Hypertrophy in Neonatal Rat Ventricular Myocytes

1996 • 176 citations

Detection of angiotensin I and II in cultured rat cardiac myocytes and fibroblasts

1992 • 172 citations

Regulation of Cytokine-inducible Nitric Oxide Synthase in Cardiac Myocytes and Microvascular Endothelial Cells

1996 • 163 citations

Induction of Mitogen-activated Protein Kinase Phosphatase 1 by the Stress-activated Protein Kinase Signaling Pathway but Not by Extracellular Signal-regulated Kinase in Fibroblasts

1996 • 162 citations

Role of transiently altered sarcolemmal membrane permeability and basic fibroblast growth factor release in the hypertrophic response of adult rat ventricular myocytes to increased mechanical activity in vitro.

1996 • 147 citations

Isolation and characterization of human and rat cardiac microvascular endothelial cells

1993 • 137 citations

Angiotensin-Converting Enzyme Inhibition and Ventricular Remodeling After Myocardial Infarction

1995 • 130 citations

Structural and functional analysis of pp70S6k.

1995 • 126 citations

Continual electric field stimulation preserves contractile function of adult ventricular myocytes in primary culture

1994 • 117 citations

Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts.

1994 • 117 citations

Endothelin-1 and Angiotensin II Receptors in Cells From Rat Hypertrophied Heart

1996 • 114 citations

Intracellular Third Loop Domain of Angiotensin II Type-2 Receptor

1996 • 109 citations

Adult rat ventricular myocytes cultured in defined medium: phenotype and electromechanical function

1993 • 105 citations

Angiotensin II induces 3CH134, a protein-tyrosine phosphatase, in vascular smooth muscle cells.

1993 • 83 citations

Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro.

1994 • 80 citations

Atrial Natriuretic Peptide Induces the Expression of MKP-1, a Mitogen-activated Protein Kinase Phosphatase, in Glomerular Mesangial Cells

1996 • 79 citations

Activation of the STAT Pathway by Angiotensin II in T3CHO/AT1A Cells

1995 • 74 citations

Cell-cell signaling between adult rat ventricular myocytes and cardiac microvascular endothelial cells in heterotypic primary culture.

1993 • 74 citations

Passive Load and Angiotensin II Evoke Differential Responses of Gene Expression and Protein Synthesis in Cardiac Myocytes

1996 • 70 citations

Angiotensin II receptor subtypes in bovine and human ventricular myocardium.

1994 • 51 citations

Contraction Accelerates Myosin Heavy Chain Synthesis Rates in Adult Cardiocytes by an Increase in the Rate of Translational Initiation

1995 • 50 citations

Regulation of bFGF expression and ANG II secretion in cardiac myocytes and microvascular endothelial cells

1997 • 48 citations

Electrically stimulated contraction accelerates protein synthesis rates in adult feline cardiocytes

1993 • 43 citations

Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture

1996 • 40 citations

Growth effects of electrically stimulated contraction on adult feline cardiocytes in primary culture

1995 • 39 citations

Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro.

1994 • 37 citations

M1Muscarinic Receptors Heterologously Expressed in Cardiac Myocytes Mediate Ras-dependent Changes in Gene Expression

1995 • 28 citations