Regulation of Cytokine-inducible Nitric Oxide Synthase in Cardiac Myocytes and Microvascular Endothelial Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Protein Lipidation in Cell Signaling

1995 • 771 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Phospholipid signaling

1995 • 561 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells

1995 • 484 citations

Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium.

1993 • 457 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro.

1994 • 436 citations

Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.

1994 • 387 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

MAP kinase by any other name smells just as sweet

1992 • 341 citations

Prevention of Lipopolysaccharide-Induced Lethal Toxicity by Tyrosine Kinase Inhibitors

1994 • 339 citations

Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes

1993 • 290 citations

Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro

1995 • 285 citations

Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing.

1992 • 279 citations

Induction of myocardial nitric oxide synthase by cardiac allograft rejection.

1994 • 212 citations

Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy.

1994 • 199 citations

The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus

1994 • 187 citations

Myocardial contractile dysfunction in the systematic inflammatory response syndrome: Role of a cytokine-inducible nitric oxide synthase in cardiac myocytes

1995 • 184 citations

Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein.

1994 • 182 citations

Endothelin‐1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes

1993 • 179 citations

Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation.

1993 • 151 citations

Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene.

1993 • 132 citations

Angiotensin II inhibits cytokine-stimulated inducible nitric oxide synthase expression in vascular smooth muscle cells

1994 • 128 citations

Induction of Nitric Oxide Synthase Activity by Cytokines in Ventricular Myocytes Is Necessary but Not Sufficient to Decrease Contractile Responsiveness to β-Adrenergic Agonists

1995 • 128 citations

Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells.

1993 • 123 citations

Production of nitric oxide by murine bone marrow cells. Inverse correlation with cellular proliferation.

1992 • 119 citations

Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells.

1992 • 98 citations

Okadaic acid activates microtubule‐associated protein kinase in quiescent fibroblastic cells

1990 • 96 citations

Contractile Responsiveness of Ventricular Myocytes to Isoproterenol Is Regulated by Induction of Nitric Oxide Synthase Activityin Cardiac Microvascular EndothelialCells in Heterotypic Primary Culture

1995 • 90 citations

Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro.

1994 • 80 citations

Activation of protein serine/threonine kinases p42, p63, and p87 in Rous sarcoma virus-transformed cells: signal transduction/transformation-dependent MBP kinases.

1992 • 68 citations

Okadaic acid stimulates the activity of microtubule associated protein kinasein PC-12 pheochromocytoma cells

1990 • 64 citations

Angiotensin II decreases inducible nitric oxide synthase expression in rat astroglial cultures

1995 • 55 citations

Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes.

1994 • 43 citations

Possible role of protein kinase C-ε isoenzyme in inhibition of interleukin 1β induction of nitric oxide synthase in rat renal mesangial cells

1994 • 39 citations

Differential modulation of human fibroblast and keratinocyte growth by the protein kinase C inhibitor GF 109203X.

1994 • 22 citations