Lack of genotoxicity of tamoxifen in human endometrium.

Endometrial Cancer in Tamoxifen-Treated Breast Cancer Patients: Findings From the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14 *

1994 • 1,259 citations

Risk of endometrial cancer after tamoxifen treatment of breast cancer

1994 • 574 citations

Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats.

1993 • 304 citations

Induction of covalent DNA adducts in rodents by tamoxifen.

1992 • 255 citations

Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

1992 • 239 citations

A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing

1991 • 142 citations

Cytochrome P-450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation.

1991 • 121 citations

Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen.

1994 • 97 citations

alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes.

1994 • 96 citations

Hydroxy derivatives of tamoxifen

1985 • 94 citations

Reduced genotoxicity of [D₅-ethyl]-tamoxifen implicates α-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen

1994 • 77 citations

Tamoxifen and the induction of cancer

1995 • 56 citations

Formation of DNA adducts in human skin maintained in short‐term organ culture and treated with coal‐tar, creosote or bitumen

1988 • 37 citations

Co-chromatography of a tamoxifen epoxide-deoxyguanylic acid adduct with a major DNA adduct formed in the livers of tamoxifen-treated rats

1994 • 37 citations