Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein

Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases.

1992 • 555 citations

Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro

1992 • 517 citations

Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.

1986 • 483 citations

The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro

1990 • 411 citations

Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA.

1991 • 405 citations

Reversal of Integration and DNA Splicing Mediated by Integrase of Human Immunodeficiency Virus

1992 • 376 citations

The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro

1990 • 350 citations

Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity.

1990 • 329 citations

Efficient oligonucleotide-directed construction of mutations in expression vectors by the gapped duplex DNA method using alternating selectable markers

1989 • 321 citations

A molecular clone of HTLV-III with biological activity

1985 • 320 citations

Retroviral integrase domains: DNA binding and the recognition of LTR sequences

1991 • 289 citations

Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells

1992 • 261 citations

Residues Critical for Retroviral Integrative Recombination in a Region That Is Highly Conserved among Retroviral/Retrotransposon Integrases and Bacterial Insertion Sequence Transposases

1992 • 244 citations

Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in Vitro

1992 • 206 citations

Functional similarities between retroviruses and the IS3 family of bacterial insertion sequences?

1990 • 205 citations

Mutational analysis of the integrase protein of human immunodeficiency virus type 2.

1992 • 203 citations

Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficient cleavage

1991 • 176 citations

Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase.

1992 • 169 citations

Integration of Retroviral DNA

1990 • 161 citations

Substrate specificity of recombinant human immunodeficiency virus integrase protein

1991 • 158 citations

Polynucleotidyl transfer reactions in transpositional DNA recombination.

1992 • 154 citations

Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNa termini mediated by the viral integrase protein

1991 • 131 citations

Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae

1992 • 127 citations

Human immunodeficiency virus type 1 integration protein: DNA sequence requirements for cleaving and joining reactions

1992 • 108 citations

Unraveling retrovirus integration

1990 • 102 citations

Defining nucleic acid-binding properties of avian retrovirus integrase by deletion analysis

1991 • 87 citations

Localization of DNA Binding Activity of HIV-1 Integrase to the C-Terminal Half of the Protein

1992 • 86 citations

The N-terminal region of HIV-1 integrase is required for integration activity, but not for DNA-binding

1992 • 77 citations

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