Opposing Effects of Reactive Oxygen Species and Cholesterol on Endothelial Nitric Oxide Synthase and Endothelial Cell Caveolae

Functional rafts in cell membranes

1997 • 9,471 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters

1997 • 1,281 citations

Dynamic activation of endothelial nitric oxide synthase by Hsp90

1998 • 1,016 citations

Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease.

1994 • 912 citations

Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

1997 • 909 citations

Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin

1997 • 808 citations

Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae

1996 • 798 citations

Src Tyrosine Kinases, Gα Subunits, and H-Ras Share a Common Membrane-anchored Scaffolding Protein, Caveolin

1996 • 770 citations

A detergent-free method for purifying caveolae membrane from tissue culture cells.

1995 • 732 citations

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling.

1996 • 677 citations

Endothelial Nitric Oxide Synthase Targeting to Caveolae

1996 • 670 citations

Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity

1997 • 647 citations

Caveolae: where incoming and outgoing messengers meet.

1993 • 616 citations

Reciprocal Regulation of Endothelial Nitric-oxide Synthase by Ca2+-Calmodulin and Caveolin

1997 • 610 citations

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

1991 • 599 citations

Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress

1995 • 572 citations

Endothelial Nitric Oxide Synthase Is Regulated by Tyrosine Phosphorylation and Interacts with Caveolin-1

1996 • 532 citations

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.

1990 • 527 citations

Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells

1994 • 520 citations

Phosphorylation of Endothelial Nitric Oxide Synthase in Response to Fluid Shear Stress

1996 • 497 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels

1997 • 468 citations

Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells

1995 • 467 citations

Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation.

1994 • 425 citations

Differential Activation of Mitogen-Activated Protein Kinases by H ₂ O ₂ and O ₂ ⁻ in Vascular Smooth Muscle Cells

1995 • 416 citations

Endothelial Nitric-oxide Synthase

1996 • 322 citations

Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization.

1993 • 275 citations

The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide

1995 • 257 citations

Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers

1997 • 241 citations

Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate.

1992 • 233 citations

Molecular Regulation of the Bovine Endothelial Cell Nitric Oxide Synthase by Transforming Growth Factor–β ₁

1995 • 194 citations

Identification, Characterization, and Comparison of the Calmodulin-binding Domains of the Endothelial and Inducible Nitric Oxide Synthases

1996 • 182 citations

Modulation of particulate nitric oxide synthase activity and peroxynitrite synthesis in cholesterol enriched endothelial cell membranes

1995 • 181 citations

Inhibitory Interactions of the Bradykinin B2 Receptor with Endothelial Nitric-oxide Synthase

1998 • 143 citations

Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting.

1995 • 141 citations

Biosynthesis and Palmitoylation of Endothelial Nitric Oxide Synthase: Mutagenesis of Palmitoylation Sites, Cysteines-15 and/or -26, Argues against Depalmitoylation-Induced Translocation of the Enzyme

1995 • 127 citations

Bradykinin-Stimulated Protein Tyrosine Phosphorylation Promotes Endothelial Nitric Oxide Synthase Translocation to the Cytoskeleton

1996 • 116 citations

Role of the Enzyme Calmodulin-binding Domain in Membrane Association and Phospholipid Inhibition of Endothelial Nitric Oxide Synthase

1995 • 96 citations

Activation of Protein Phosphorylation by Oxidants in Vascular Endothelial Cells: Identification of Tyrosine Phosphorylation of Caveolin

1997 • 71 citations

Endothelial nitric oxide generating enzyme(s) in the bovine aorta: subcellular location and metabolic characterization.

1990 • 67 citations

Age, Hypertension and Hypercholesterolaemia Alter Endothelium‐Dependent Vascular Regulation

1992 • 55 citations

Activation and tyrosine phosphorylation of p72syk as well as calcium mobilization after hydrogen peroxide stimulation in peripheral blood lymphocytes

1995 • 49 citations

Downregulation of high density lipoprotein receptor activity of cultured fibroblasts by platelet-derived growth factor.

1987 • 39 citations

EXPLANTED VEIN GRAFTS WITH AN INTACT ENDOTHELIUM DEMONSTRATE REDUCED FOCAL EXPRESSION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE SPECIFIC TO ATHEROSCLEROTIC SITES

1996 • 33 citations