Mechanisms of Estrogen Receptor Signaling: Convergence of Genomic and Nongenomic Actions on Target Genes

STATs and Gene Regulation

1997 • 3,927 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Mechanisms of Estrogen Action

2001 • 1,945 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

2000 • 1,411 citations

Effects of Postmenopausal Estrogen Replacement on the Concentrations and Metabolism of Plasma Lipoproteins

1991 • 1,158 citations

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors

2001 • 1,123 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ERα and ERβ Expressed in Chinese Hamster Ovary Cells

1999 • 1,046 citations

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.

1996 • 964 citations

Nongenomic actions of steroid hormones

2003 • 944 citations

Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

1999 • 895 citations

Serine phosphorylation of STATs

2000 • 873 citations

Estrogen receptor pathways to AP-1

2000 • 867 citations

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

1995 • 692 citations

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.

1994 • 667 citations

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.

1995 • 665 citations

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity

2001 • 661 citations

Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor

1998 • 618 citations

ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury

2002 • 546 citations

Membrane estrogen receptors identified by multiple antibody labeling and impeded‐ligand binding

1995 • 532 citations

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

1994 • 527 citations

Coregulator Codes of Transcriptional Regulation by Nuclear Receptors

2001 • 507 citations

Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex

1990 • 486 citations

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

1997 • 478 citations

Role of plasmalemmal caveolae in signal transduction

1998 • 466 citations

PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

2001 • 463 citations

Estrogen Receptor α Rapidly Activates the IGF-1 Receptor Pathway

2000 • 461 citations

Proximal Events in Signaling by Plasma Membrane Estrogen Receptors

2003 • 460 citations

Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1

1999 • 460 citations

Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human

1998 • 452 citations

Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells

2003 • 442 citations

Estrogen-induced Activation of Cdk4 and Cdk2 during G1-S Phase Progression Is Accompanied by Increased Cyclin D1 Expression and Decreased Cyclin-dependent Kinase Inhibitor Association with Cyclin E-Cdk2

1997 • 438 citations

Genomic Targets of Nuclear Estrogen Receptors

2004 • 426 citations

Opposing Action of Estrogen Receptors α and β on Cyclin D1 Gene Expression

2002 • 426 citations

Transcriptional activation of genes by 17β-estradiol through estrogen receptor-Sp1 interactions

2001 • 414 citations

Estrogen Receptor α and Endothelial Nitric Oxide Synthase Are Organized Into a Functional Signaling Module in Caveolae

2000 • 409 citations

Linkage of Rapid Estrogen Action to MAPK Activation by ERα-Shc Association and Shc Pathway Activation

2002 • 403 citations

Functional Synergy between the Transcription Factor Sp1 and the Estrogen Receptor

1997 • 399 citations

Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements

2000 • 393 citations

Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer.

1994 • 390 citations

Transcriptional cross-talk, the second mode of steroid hormone receptor action

1998 • 390 citations

ERs Associate with and Regulate the Production of Caveolin: Implications for Signaling and Cellular Actions

2002 • 380 citations

The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions

1999 • 369 citations

Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element

1999 • 358 citations

Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors α and β

2000 • 352 citations

Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

1997 • 337 citations

Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium

1999 • 336 citations

Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha , but not by ERbeta

1999 • 331 citations

RETRACTED: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade

2002 • 329 citations

Plasma Membrane Estrogen Receptors Exist and Functions as Dimers

2004 • 327 citations

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

1994 • 307 citations

Nongenomic Stimulation of Nitric Oxide Release by Estrogen Is Mediated by Estrogen Receptor α Localized in Caveolae

1999 • 304 citations

Selective Phosphorylations of the SRC-3/AIB1 Coactivator Integrate Genomic Reponses to Multiple Cellular Signaling Pathways

2004 • 297 citations

Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain.

1996 • 283 citations

Estrogen Receptor Binding to DNA Is Not Required for Its Activity through the Nonclassical AP1 Pathway

2001 • 279 citations

Plasma Membrane Estrogen Receptors Are Coupled to Endothelial Nitric-oxide Synthase through Gαi

2001 • 279 citations

Estrogen-Dependent Cyclin E-cdk2 Activation through p21 Redistribution

1997 • 277 citations

ERβ Has Nongenomic Action in Caveolae

2002 • 265 citations

Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids

2003 • 245 citations

Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids

2003 • 227 citations

Rapid Activation of MAP Kinase by Estrogen in the Bone Cell Line

1997 • 225 citations

Estrogen action and cytoplasmic signaling pathways. Part II: the role of growth factors and phosphorylation in estrogen signaling

2002 • 219 citations

Estrogen Regulation of Cyclin D1 Gene Expression in ZR-75 Breast Cancer Cells Involves Multiple Enhancer Elements

2001 • 200 citations

Estrogen-Induced c-fos Protooncogene Expression in MCF-7 Human Breast Cancer Cells: Role of Estrogen Receptor Sp1 Complex Formation*

1998 • 190 citations

Sp1 Binding Sites and An Estrogen Response Element Half-Site Are Involved in Regulation of the Human Progesterone Receptor A Promoter

2000 • 182 citations

ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry

1999 • 179 citations

Phosphorylation of Rat Serine 105 or Mouse Threonine 217 in C/EBPβ Is Required for Hepatocyte Proliferation Induced by TGFα

1999 • 165 citations

S-palmitoylation modulates human estrogen receptor-α functions

2004 • 164 citations

Estrogen Receptor-mediated Activation of the Serum Response Element in MCF-7 Cells through MAPK-dependent Phosphorylation of Elk-1

2001 • 158 citations

Signal Transducers and Activators of Transcription as Downstream Targets of Nongenomic Estrogen Receptor Actions

2002 • 143 citations

Resistance to tamoxifen‐induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancer

2001 • 140 citations

Ligand-Dependent Repression of the Erythroid Transcription Factor GATA-1 by the Estrogen Receptor

1995 • 132 citations

Distinct Nongenomic Signal Transduction Pathways Controlled by 17β-Estradiol Regulate DNA Synthesis and Cyclin D₁Gene Transcription in HepG2 Cells

2002 • 131 citations

Estren Is a Selective Estrogen Receptor Modulator with Transcriptional Activity

2003 • 126 citations

Characterization of the Physical Interaction between Estrogen Receptor α and JUN Proteins

2001 • 124 citations

Glucocorticoid Receptor/Signal Transducer and Activator of Transcription 5 (STAT5) Interactions Enhance STAT5 Activation by Prolonging STAT5 DNA Binding and Tyrosine Phosphorylation

1999 • 123 citations

Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor family

1999 • 120 citations

Rapid Nongenomic E2 Effects on p42/p44 MAPK, Activator Protein-1, and cAMP Response Element Binding Protein in Rat White Adipocytes

2002 • 119 citations

Glucocorticoids Antagonize Ap-1 by Inhibiting the Activation/Phosphorylation of Jnk without Affecting Its Subcellular Distribution

2000 • 115 citations

Mechanical Strain and Estrogen Activate Estrogen Receptor α in Bone Cells

2001 • 115 citations

Requirement of Sp1 and Estrogen Receptor α Interaction in 17β-Estradiol-Mediated Transcriptional Activation of the Low Density Lipoprotein Receptor Gene Expression*

2001 • 115 citations

Estrogen Receptor β Activates the Human Retinoic Acid Receptorα -1 Promoter in Response to Tamoxifen and Other Estrogen Receptor Antagonists, but Not in Response to Estrogen

1999 • 106 citations

Inhibition of Vascular Endothelial Growth Factor Expression in HEC1A Endometrial Cancer Cells through Interactions of Estrogen Receptor α and Sp3 Proteins

2000 • 89 citations

Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site

2000 • 86 citations

Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells

2002 • 85 citations

Estradiol regulation of the human retinoic acid receptor alpha gene in human breast carcinoma cells is mediated via an imperfect half-palindromic estrogen response element and Sp1 motifs.

1995 • 84 citations

Mechanisms of Estrogen Receptor Action in the Myocardium

2001 • 81 citations

Cross-Talk Between ERs and Signal Transducer and Activator of Transcription 5 Is E2 Dependent and Involves Two Functionally Separate Mechanisms

2001 • 80 citations

FRA-1 Expression Level Modulates Regulation of Activator Protein-1 Activity by Estradiol in Breast Cancer Cells

1998 • 77 citations

Androgen Receptor-Mediated Antagonism of Estrogen-Dependent Low Density Lipoprotein Receptor Transcription in Cultured Hepatocytes

1997 • 76 citations

A Splice Variant of Estrogen Receptor β Missing Exon 3 Displays Altered Subnuclear Localization and Capacity for Transcriptional Activation*

2001 • 75 citations

Estrogen-induced proliferation of normal endometrial glandular cells is initiated by transcriptional activation of cyclin D1 via binding of c-Jun to an AP-1 sequence

2004 • 66 citations

Estrogen receptor-dependent activation of AP-1 via non-genomic signalling.

2004 • 65 citations

Raloxifene Inhibits Estrogen-induced Up-regulation of Telomerase Activity in a Human Breast Cancer Cell Line

2003 • 63 citations

Cross-talk between Stat5b and estrogen receptor-alpha and -beta in mammary epithelial cells

2001 • 49 citations

Positive and negative effects of nuclear receptors on transcription activation by AP‐1 of the human choline acetyltransferase proximal promoter

1995 • 45 citations

Mutations in the Estrogen Receptor DNA-binding Domain Discriminate between the Classical Mechanism of Action and Cross-talk with Stat5b and Activating Protein 1 (AP-1)

2002 • 45 citations

Role of tyrosine kinase signaling in estrogen-induced LDL receptor gene expression in HepG2 cells

2002 • 37 citations

Nongenomic Activity and Subsequent c-fos Induction by Estrogen Receptor Ligands Are Not Sufficient to Promote Deoxyribonucleic Acid Synthesis in Human Endometrial Adenocarcinoma Cells

2002 • 31 citations

Deleted Work

1955 • 0 citations