Wortmannin-Enhanced X-Ray-Induced Apoptosis of Human T-Cell Leukemia MOLT-4 Cells Possibly through the JNK/SAPK Pathway

Cellular survival: a play in three Akts

1999 • 4,229 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Proteases to die for

1998 • 1,241 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Rosette-Forming Human Lymphoid Cell Lines. I. Establishment and Evidence for Origin of Thymus-Derived Lymphocytes<xref ref-type="fn" rid="FN1">2</xref>

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Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

1999 • 558 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

Ataxia-telangiectasia and cellular responses to DNA damage.

1995 • 378 citations

The Phosphatidylinositol 3-Kinase (PI3K)-Akt Pathway Suppresses Bax Translocation to Mitochondria

2002 • 369 citations

Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.

1997 • 215 citations

Stress signals for apoptosis: ceramide and c-Jun kinase

1998 • 211 citations

Ceramide Formation Leads to Caspase-3 Activation during Hypoxic PC12 Cell Death

1998 • 207 citations

PI3-kinase inhibition: a target for drug development?

2000 • 194 citations

Determination of cell fate by c-Abl activation in the response to DNA damage

1998 • 170 citations

The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

2000 • 156 citations

The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage.

1996 • 149 citations

Review: ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia

1999 • 138 citations

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

1999 • 134 citations

Ataxia Telangiectasia-mutated Gene Product Inhibits DNA Damage-induced Apoptosis via Ceramide Synthase

1999 • 120 citations

Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells

1996 • 118 citations

Akt Is Activated in Response to an Apoptotic Signal

2001 • 103 citations

Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells

2000 • 97 citations

Wortmannin Sensitizes Mammalian Cells to Radiation by Inhibiting the DNA-Dependent Protein Kinase-Mediated Rejoining of Double-Strand Breaks

1999 • 82 citations

Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation.

1995 • 75 citations

A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation

1998 • 75 citations

Wortmannin Inhibits Repair of DNA Double-Strand Breaks in Irradiated Normal Human Cells

1998 • 74 citations

Deregulated apoptosis in ataxia telangiectasia: association with clinical stigmata and radiosensitivity.

1996 • 73 citations

Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells

2000 • 69 citations

Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis

2001 • 66 citations

Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation

2000 • 58 citations

A Possible Mechanism for Hyperthermic Radiosensitization Mediated through Hyperthermic Lability of Ku Subunits in DNA-Dependent Protein Kinase

1997 • 50 citations

Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells

1999 • 50 citations

Interphase death and reproductive death in X-irradiated MOLT-4 cells.

1993 • 46 citations

Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4

2000 • 35 citations

Evaluation of the relative contribution of p53-mediated pathway in X-ray-induced apoptosis in human leukemic MOLT-4 cells by transfection with a mutant p53 gene at different expression levels

2001 • 34 citations

Interphase Death and Reproductive Death in X-Irradiated MOLT-4 Cells

1993 • 33 citations

Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway Protects against Interleukin-3 Starvation but Not DNA Damage-induced Apoptosis

2001 • 31 citations

p41 as a Possible Marker for Cell Death Is Generated by Caspase Cleavage of p42/SETβ in Irradiated MOLT-4 Cells

2000 • 22 citations

Effects of Protein Kinase Inhibitors on the Accumulation Kinetics of p53 Protein in Normal Human Embryo Cells following X-irradiation

1999 • 21 citations

Correlation between Unirradiated Cell TP53 Protein Levels and Radiosensitivity in MOLT-4 Cells

1999 • 20 citations

Sensitization by Wortmannin of Heat- or X-ray Induced Cell Death in Cultured Chinese Hamster V79 Cells

2000 • 17 citations