Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells

Mitochondria and Apoptosis

1998 • 8,909 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

Bcl-2 Gene Family and the Regulation of Programmed Cell Death

1994 • 725 citations

Role of Bcl‐2 family proteins in apoptosis: apoptosomes or mitochondria?

1998 • 705 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

1994 • 583 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

1997 • 390 citations

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.

1996 • 371 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.

1996 • 360 citations

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

1997 • 302 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis.

1997 • 259 citations

Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells.

1994 • 249 citations

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

1996 • 217 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

Ceramide Formation Leads to Caspase-3 Activation during Hypoxic PC12 Cell Death

1998 • 207 citations

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

1996 • 203 citations

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

1998 • 186 citations

Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage–induced apoptosis

1999 • 176 citations

A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation

1996 • 153 citations

T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.

1996 • 128 citations

Fas-induced apoptosis of T cells occurs independently of ceramide generation

1997 • 123 citations

Anti-immunoglobulin-induced Apoptosis in WEHI 231 Cells Involves the Slow Formation of Ceramide from Sphingomyelin and Is Blocked by bcl-xL

1997 • 114 citations

Bax Can Antagonize Bcl-XL during Etoposide and Cisplatin-induced Cell Death Independently of Its Heterodimerization with Bcl-XL

1996 • 101 citations

Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents

1998 • 73 citations

Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells

1997 • 72 citations

Apoptotic Signal of Fas Is Not Mediated by Ceramide

1998 • 66 citations

Changes in the Activity and mRNA Levels of Phospholipase D During Ceramide‐Induced Apoptosis in Rat C6 Glial Cells

1997 • 61 citations

Evidence against an early signalling role for ceramide in Fas-mediated apoptosis

1997 • 55 citations

On the complexities of ceramide changes in cells undergoing apoptosis: lack of evidence for a second messenger function in apoptotic induction

1999 • 39 citations

Overexpression ofBax sensitizes breast cancer MCF-7 cells to cisplatin and etoposide

1997 • 38 citations

Transfection of C6 glioma cells with the bax gene and increased sensitivity to treatment with cytosine arabinoside

1998 • 17 citations

Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment.

1996 • 15 citations