SLP-76 Expression Is Restricted to Hemopoietic Cells of Monocyte, Granulocyte, and T Lymphocyte Lineage and Is Regulated During T Cell Maturation and Activation

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

1994 • 498 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

Interaction of Shc with the ζ Chain of the T Cell Receptor Upon T Cell Activation

1993 • 343 citations

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

1996 • 343 citations

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

1995 • 337 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Clonal expansion precedes anergy and death of V_β8⁺ peripheral T cells responding to staphylococcal enterotoxin B in vivo

1991 • 330 citations

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

1994 • 299 citations

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1997 • 265 citations

A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.

1994 • 246 citations

Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases

1997 • 238 citations

CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection

1993 • 225 citations

Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

1997 • 224 citations

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.

1996 • 194 citations

Casein Kinase II Phosphorylates IκBα at S-283, S-289, S-293, and T-291 and Is Required for Its Degradation

1996 • 187 citations

GRB2 and Phospholipase C-7γ1 Associate with a 36- to 38-Kilodalton Phosphotyrosine Protein after T-Cell Receptor Stimulation

1994 • 181 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

The effect of recombinant mast cell growth factor on purified murine hematopoietic stem cells.

1991 • 157 citations

Interactions of Cbl with Two Adaptor Proteins, Grb2 and Crk, upon T Cell Activation

1996 • 136 citations

Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.

1996 • 129 citations

Positive selection of thymocytes bearing αβ T cell receptors

1997 • 124 citations

G₁ Cyclin Degradation: the PEST Motif of Yeast Cln2 Is Necessary, but Not Sufficient, for Rapid Protein Turnover

1994 • 108 citations

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.

1994 • 103 citations

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit.

1995 • 98 citations

Molecular basis for developmental changes in interleukin-2 gene inducibility.

1993 • 96 citations

Basal Phosphorylation of the PEST Domain in IκBβ Regulates Its Functional Interaction with the c-rel Proto-Oncogene Product

1996 • 91 citations

Three domains of SLP-76 are required for its optimal function in a T cell line.

1997 • 87 citations

G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover.

1994 • 74 citations

SLP-76 Is a Substrate of the High Affinity IgE Receptor-stimulated Protein Tyrosine Kinases in Rat Basophilic Leukemia Cells

1997 • 66 citations

A Role for Shc, Grb2, and Raf-1 in FcγRI Signal Relay

1996 • 43 citations

Molecular Basis for Developmental Changes in Interleukin-2 Gene Inducibility

1993 • 30 citations

Chapter 41 Identafication and Purafication of Murine Hematopoietic Stem Cellsby Flow Cytometry

1990 • 24 citations

A signal strength hypothesis of thymic selection: preliminary considerations

1995 • 11 citations