Molecular features of hypothalamic plaques in Alzheimer's disease.

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles

1985 • 1,425 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

1989 • 904 citations

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1988 • 584 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

1986 • 577 citations

Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease

1990 • 567 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats

1987 • 490 citations

Isolation of Low‐Molecular‐Weight Proteins from Amyloid Plaque Fibers in Alzheimer's Disease

1986 • 443 citations

Identification of the major multiphosphorylation site in mammalian neurofilaments.

1988 • 394 citations

Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease.

1989 • 336 citations

Patterns of gliosis in alzheimer's disease and aging cerebrum

1989 • 318 citations

Distribution of tau proteins in the normal human central and peripheral nervous system.

1989 • 314 citations

Distribution of Alzheimer's neurofibrillary changes in the brain stem and hypothalamus of senile dementia

1966 • 299 citations

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by? protein immunostaining

1988 • 280 citations

Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals

1988 • 270 citations

Biochemistry of Altered Brain Proteins in Alzheimer's Disease

1989 • 261 citations

Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease.

1989 • 241 citations

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.

1987 • 222 citations

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease.

1990 • 209 citations

Alzheimer changes in nondemented patients younger than sixty‐five: Possible early stages of Alzheimer's disease and senile dementia of Alzheimer type

1985 • 209 citations

Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.

1990 • 175 citations

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

1990 • 154 citations

Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2.

1987 • 147 citations

Hypothalamic pathology in Alzheimer's disease

1987 • 146 citations

The supraoptic and paraventricular nuclei of the human hypothalamus in relation to sex, age and Alzheimer's disease

1990 • 131 citations

Morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon

1984 • 130 citations

Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins.

1988 • 125 citations

Clathrin structure characterized with monoclonal antibodies. I. Analysis of multiple antigenic sites.

1985 • 117 citations

Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease

1990 • 106 citations

Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques.

1988 • 101 citations

Subcortical degeneration in Alzheimer's disease

1985 • 99 citations

Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease

1989 • 90 citations

Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains.

1991 • 85 citations

Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads.

1991 • 82 citations

Modified Bielschowsky and Immunocytochemical Studies on Cerebellar Plaques in Alzheimer's Disease

1990 • 72 citations

Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system.

1989 • 68 citations

Vasopressin Response to Dehydration in Alzheimer's Disease

1989 • 61 citations

Ubiquitin and microtubule-associated protein tau immunoreactivity each define distinct structures with differing distributions and solubility properties in Alzheimer brain.

1988 • 58 citations

Distribution of phosphate-independent MAP2 epitopes revealed with monoclonal antibodies in microwave-denatured human nervous system tissues

1989 • 54 citations

Properties of antigenic determinants that distinguish neurofibrillary tangles in progressive supranuclear palsy and Alzheimer's disease.

1988 • 45 citations

Neuronal hypertrophy in the human supraoptic and paraventricular nucleus in aging and Alzheimer's disease

1990 • 45 citations

Neuron-specific expression of high-molecular-weight clathrin light chain

1990 • 38 citations

CONGO RED BIREFRINGENT STRUCTURES IN THE HYPOTHALAMUS IN SENILE DEMENTIA OF THE ALZHEIMER TYPE

1988 • 28 citations

Cellular and molecular biology of alzheimer's disease

1989 • 25 citations

Alterations in vasopressin regulation in Alzheimer's disease.

1988 • 21 citations

Vulnerability of the Neuronal Cytoskeleton in Aging and Alzheimer Disease: Widespread Involvement of All Three Major Filament Systems

1991 • 18 citations

Clinical Neuropharmacology of Sleep

1990 • 14 citations

Growth hormone responses to growth hormone releasing factor in primary degenerative dementia

1989 • 8 citations