The roles of cytochrome b₅ in cytochrome P450 reactions

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

Cytochrome b 5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer

1998 • 537 citations

A Function of Cytochrome b5 in Fatty Acid Desaturation by Rat Liver Microsomes

1971 • 389 citations

Identification of the Binding Site on Cytochrome P450 2B4 for Cytochrome b 5 and Cytochrome P450 Reductase

1998 • 285 citations

Roles of NADPH-P450 Reductase and Apo- and Holo-Cytochrome b5 on Xenobiotic Oxidations Catalyzed by 12 Recombinant Human Cytochrome P450s Expressed in Membranes of Escherichia coli

2002 • 229 citations

Association of Multiple Developmental Defects and Embryonic Lethality with Loss of Microsomal NADPH-Cytochrome P450 Oxidoreductase

2002 • 210 citations

Cytochrome b5 reduction by NADPH-cytochrome P-450 reductase.

1979 • 199 citations

Lack of Electron Transfer from Cytochrome b5 in Stimulation of Catalytic Activities of Cytochrome P450 3A4

1996 • 192 citations

Oxidation-reduction properties of rat liver cytochromes P-450 and NADPH-cytochrome P-450 reductase related to catalysis in reconstituted systems

1983 • 177 citations

P450c17 Mutations R347H and R358Q Selectively Disrupt 17,20-Lyase Activity by Disrupting Interactions with P450 Oxidoreductase and Cytochrome b₅

1999 • 177 citations

Kinetics of Ferric Cytochrome P450 Reduction by NADPH−Cytochrome P450 Reductase: Rapid Reduction in the Absence of Substrate and Variations among Cytochrome P450 Systems

1997 • 166 citations

Cytochrome b5, its functions, structure and membrane topology

1995 • 153 citations

Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

1996 • 140 citations

Biochemical Differences between Rat and Human Cytochrome P450c17 Support the Different Steroidogenic Needs of These Two Species

1999 • 130 citations

Reconstitution of Recombinant Cytochrome P450 2C10(2C9) and Comparison with Cytochrome P450 3A4 and Other Forms: Effects of Cytochrome P450–P450 and Cytochrome P450–b5Interactions

1997 • 124 citations

The metabolism of methylated aminoazo dyes. VI. Intracellular distribution and properties of the demethylase system.

1957 • 121 citations

Role of Cytochrome b5 in Hydroxylation by a Reconstituted Cytochrome P-450-containing System

1974 • 112 citations

Direct evidence for electron transfer from ferrous cytochrome b5 to the oxyferrous intermediate of liver microsomal cytochrome P-450 LM2.

1981 • 109 citations

Chemical characterization of protein-protein interactions between cytochrome P-450 and cytochrome b5.

1985 • 104 citations

Stimulation of Cytochrome P450 Reactions by Apo-cytochromeb 5

2001 • 103 citations

Effects of cytochrome b5 on cytochrome P-450-catalyzed reactions. Studies with manganese-substituted cytochrome b5.

1984 • 91 citations

Interaction of Apo-cytochrome b₅ with Cytochromes P4503A4 and P45017A: Relevance of Heme Transfer Reactions

2001 • 89 citations

Biodiversity of the P450 catalytic cycle: yeast cytochrome b₅/NADH cytochrome b₅ reductase complex efficiently drives the entire sterol 14‐demethylation (CYP51) reaction

1999 • 87 citations

Electron Shuttle between Membrane-Bound Cytochrome P450 3A4 andb₅Rules Uncoupling Mechanisms

1998 • 84 citations

Immunochemical evidence for the participation of cytochrome b5 in the NADH synergism of the NADPH-dependent mono-oxidase system of hepatic microsomes

1974 • 77 citations

INTERACTIONS BETWEEN CYTOCHROME P450 AND CYTOCHROME b₅

1999 • 73 citations

TESTICULAR CYTOCHROME P-450 AND IRON-SULFUR PROTEIN AS RELATED TO STEROID METABOLISM

1973 • 67 citations

Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes

1996 • 65 citations

Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system.

1990 • 64 citations

Disruption of the Saccharomyces Cerevlsiae gene for NADPH-cytochrome P450 reductase causes increased sensitivity to ketoconazole

1989 • 63 citations

Immunohistochemical Study of Cytochrome b5 in Human Adrenal Gland and in Adrenocortical Adenomas from Patients with Cushing's Syndrome.

1998 • 56 citations

The Kinetic and Spectral Characterization of the E. coli-Expressed Mammalian CYP4A7: Cytochrome b5 Effects Vary with Substrate

2001 • 54 citations

Purification to homogeneity and enzymological characterization of a functional covalent complex composed of cytochromes P-450 isozyme 2 and b5 from rabbit liver.

1987 • 54 citations

Role of the electron transfer system in microsomal drug monooxygenase reaction catalyzed by cytochrome P-450

1984 • 53 citations

Effects of Human Cytochrome b5on CYP3A4 Activity and Stabilityin Vivo

1999 • 52 citations

Influence of Ionic Strength on the P450 Monooxygenase Reaction and Role of Cytochrome b5 in the Process

1994 • 40 citations

Mechanism of interaction between cytochromes P-450 RLM5 and b5: Evidence for an electrostatic mechanism involving cytochrome b5 heme propionate groups

1986 • 36 citations

DPNH synergism of TPNH-dependent mixed function oxidase reactions.

1973 • 34 citations

Immunochemical study on the participation of cytochrome b5 in drug oxidation reactions of mouse liver microsomes

1979 • 32 citations

Roles of residues 129 and 209 in the alteration by cytochrome b5 of hydroxylase activities in mouse 2A P450S

1992 • 29 citations

Mutagenicity of nitrosamines in methyltransferase-deficient strains of Salmonella typhimurium coexpressing human cytochrome P450 2E1 and reductase

2000 • 25 citations

Genetically engineered yeast cells and their applications

1995 • 22 citations

Human Sterol 14α-Demethylase Activity Is Enhanced by the Membrane-Bound State of Cytochrome b5

2001 • 19 citations

Cytochrome b5 coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium

2001 • 17 citations

Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes

1985 • 14 citations