Effects of Human Cytochrome b5on CYP3A4 Activity and Stabilityin Vivo

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Cytochrome b 5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer

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1978 • 303 citations

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

1992 • 228 citations

Lack of Electron Transfer from Cytochrome b5 in Stimulation of Catalytic Activities of Cytochrome P450 3A4

1996 • 192 citations

Enhanced in vivo monooxygenase activities of mammalian P450s in engineered yeast cells producing high levels of NADPH-P450 reductase and human cytochrome b5

1993 • 160 citations

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

1995 • 141 citations

Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

1996 • 140 citations

Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains.

1994 • 136 citations

Roles of Divalent Metal Ions in Oxidations Catalyzed by Recombinant Cytochrome P450 3A4 and Replacement of NADPH-Cytochrome P450 Reductase with Other Flavoproteins, Ferredoxin, and Oxygen Surrogates

1995 • 128 citations

Reconstitution of Recombinant Cytochrome P450 2C10(2C9) and Comparison with Cytochrome P450 3A4 and Other Forms: Effects of Cytochrome P450–P450 and Cytochrome P450–b5Interactions

1997 • 124 citations

Role of phospholipids in reconstituted cytochrome P 450 3A form and mechanism of their activation of catalytic activity

1992 • 124 citations

A General Strategy for the Expression of Recombinant Human Cytochrome P450s inEscherichia coliUsing Bacterial Signal Peptides: Expression of CYP3A4, CYP2A6, and CYP2E1

1997 • 121 citations

Oxidation Kinetics of Ethanol by Human Cytochrome P450 2E1

1997 • 102 citations

The High-Level Expression in Escherichia coli of the Membrane-Bound Form of Human and Rat Cytochrome b5 and Studies on Their Mechanism of Function

1994 • 92 citations

Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli

1996 • 92 citations

Effects of cytochrome b5 on cytochrome P-450-catalyzed reactions. Studies with manganese-substituted cytochrome b5.

1984 • 91 citations

CYP3A4 Expressed by Insect Cells Infected with a Recombinant Baculovirus Containing Both CYP3A4 and Human NADPH-Cytochrome P450 Reductase Is Catalytically Similar to Human Liver Microsomal CYP3A4

1995 • 91 citations

Reconstitution Premixes for Assays Using Purified Recombinant Human Cytochrome P450, NADPH-Cytochrome P450 Reductase, and Cytochromeb5

1997 • 90 citations

Effects of conditions for reconstitution with cytochrome b5 on the formation of products in cytochrome P-450-catalyzed reactions.

1986 • 70 citations

Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes

1996 • 65 citations

Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system.

1990 • 64 citations

Xenobiotic metabolizing enzymes are not restricted to parenchymal cells in rat liver.

1987 • 63 citations

The interaction of cytochrome b5 with four cytochrome P-450 enzymes from the untreated rat.

1985 • 55 citations

Recombinant yeast in drug metabolism

1993 • 44 citations

Baculovirus Expression of Human P450 2E1 and Cytochrome b5: Spectral and Catalytic Properties and Effect of b5 on the Stoichiometry of P450 2E1-Catalyzed Reactions

1995 • 38 citations

The complete nucleotide sequence of human liver cytochrome b5 mRNA

1988 • 34 citations

Recombinant DNA technology as an investigative tool in drug metabolism research

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Expression of drug-metabolizing enzymes

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Influence of cytochrome b5 on the stoichiometry of the different oxidative reactions catalyzed by liver microsomal cytochrome P-450.

1987 • 27 citations

In‐vitro evidence for the regulation of 17,20‐lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome

1994 • 27 citations