Cytochrome b5, its functions, structure and membrane topology

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

The Enzymes of Biological Membranes

1985 • 1,362 citations

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1994 • 1,263 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

Prediction of Protein Structure and the Principles of Protein Conformation

1989 • 814 citations

Eight Histidine Residues Are Catalytically Essential in a Membrane-Associated Iron Enzyme, Stearoyl-CoA Desaturase, and Are Conserved in Alkane Hydroxylase and Xylene Monooxygenase

1994 • 764 citations

The Photosynthetic Reaction Center from the Purple Bacterium Rhodopseudomonas viridis

1989 • 670 citations

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

Purification and Properties of Rat Liver Microsomal Stearyl Coenzyme A Desaturase

1974 • 471 citations

A Form of Cytochrome b ₅ That Contains an Additional Hydrophobic Sequence of 40 Amino Acid Residues

1971 • 453 citations

Principles and Patterns of Protein Conformation

1989 • 421 citations

The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene

1990 • 409 citations

The oxidative desaturation of unsaturated fatty acids in animals

1974 • 394 citations

On the membrane topology of vertebrate cytochrome P-450 proteins.

1988 • 362 citations

An hypothetical structure for an intermolecular electron transfer complex of cytochromes c and b5

1976 • 350 citations

Long-Range Electron Transfer in Heme Proteins

1986 • 311 citations

Methemoglobinemia

1993 • 311 citations

HYPERTROPHY OF THE AGRANULAR ENDOPLASMIC RETICULUM IN HAMSTER LIVER INDUCED BY PHENOBARBITAL (WITH A REVIEW ON THE FUNCTIONS OF THIS ORGANELLE IN LIVER)

1966 • 311 citations

The Structure and Insertion of Integral Proteins in Membranes

1990 • 304 citations

Increased amounts of HMG-CoA reductase induce "karmellae": a proliferation of stacked membrane pairs surrounding the yeast nucleus.

1988 • 293 citations

The Structure of Ferrocytochrome c at 2.45 A Resolution

1973 • 284 citations

Catalysis of Methaemoglobin Reduction by Erythrocyte Cytochrome b5 and Cytochrome b5 Reductase

1971 • 282 citations

Prediction of protein structure and principles of protein conformation

1990 • 267 citations

Structure of the reaction center from Rhodobacter sphaeroides R-26: membrane-protein interactions.

1987 • 229 citations

Three-dimensional fourier synthesis of calf liver cytochrome b5 at 2.8 Å resolution

1972 • 219 citations

Hepatic cytochromeP-450 monooxygenase system

1983 • 214 citations

Sesamin is a potent and specific inhibitor of Δ5 desaturase in polyunsaturated fatty acid biosynthesis

1991 • 207 citations

The three‐dimensional structure of porin from Rhodobacter capsulatus at 3 Å resolution

1990 • 204 citations

Cytochrome b5 reduction by NADPH-cytochrome P-450 reductase.

1979 • 199 citations

Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1

1993 • 198 citations

Purification by Means of Detergents and Properties of Cytochrome b5 from Liver Microsomes

1968 • 185 citations

Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer.

1985 • 176 citations

A new chromatographic approach to the resolution of individual gangliosides. Ganglioside mapping.

1978 • 171 citations

Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase.

1993 • 167 citations

Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal.

1992 • 161 citations

A new chromatographic approach to the resolution of individual gangliosides

1978 • 158 citations

Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5.

1983 • 155 citations

Molecular Dynamics of a Cytochrome c-Cytochrome b ₅ Electron Transfer Complex

1987 • 152 citations

Site-directed mutagenesis of cytochrome c shows that an invariant Phe is not essential for function

1985 • 151 citations

Specificity of unsaturated fatty acid-regulated expression of the Saccharomyces cerevisiae OLE1 gene.

1992 • 142 citations

Acetone-inducible cytochrome P-450: Purification, catalytic activity, and interaction with cytochrome b5

1986 • 135 citations

Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes

1981 • 135 citations

Congenital Methemoglobinemia with a Deficiency of Cytochrome B5

1986 • 132 citations

Putidaredoxin competitively inhibits cytochrome b5-cytochrome P-450cam association: a proposed molecular model for a cytochrome P-450cam electron-transfer complex

1989 • 131 citations

Biochemical properties of cytochrome b5-dependent microsomal fatty acid elongation and identification of products.

1980 • 129 citations

An unusual yet strongly conserved flavoprotein reductase in bacteria and mammals

1991 • 126 citations

Cytochrome b5 stimulates purified testicular microsomal cytochrome P-450 (C21 side-chain cleavage)

1982 • 124 citations

Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes

1994 • 124 citations

The binding of cytochrome b5 to phospholipid vesicles and biological membranes. Effect of orientation on intermembrane transfer and digestion by carboxypeptidase Y.

1979 • 123 citations

Spectrophotometric analysis of the interaction between cytochrome b5 and cytochrome c

1982 • 122 citations

Purified liver microsomal cytochrome P-450. Electron-accepting properties and oxidation-reduction potential.

1975 • 120 citations

Probing the Mechanisms of Macromolecular Recognition: the Cytochrome b ₅ -Cytochrome C Complex

1988 • 118 citations

Structure of cytochrome b5 and its topology in the microsomal membrane

1989 • 117 citations

Modification and identification of cytochrome b5 carboxyl groups involved in protein-protein interaction with cytochrome b5 reductase.

1979 • 114 citations

Studies on the Biosynthesis of Microsomal Membrane Proteins

1982 • 114 citations

The carboxy-terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulum.

1992 • 113 citations

Structure-Function Studies on Bacteriorhodopsin

1989 • 112 citations

The surface-exposed tyrosine residue Tyr83 of pea plastocyanin is involved in both binding and electron transfer reactions with cytochrome f.

1991 • 112 citations

THE OXIDATION-REDUCTION STOICHIOMETRY AND POTENTIAL OF MICROSOMAL CYTOCHROME

1956 • 107 citations

Chemical characterization of protein-protein interactions between cytochrome P-450 and cytochrome b5.

1985 • 104 citations

N-demethylation of N-nitrosodimethylamine catalyzed by purified rat hepatic microsomal cytochrome P-450: Isozyme specificity and role of cytochrome b5

1986 • 103 citations

Evidence for the Participation of Cytochrome b5 in Plasmalogen Biosynthesis

1974 • 102 citations

Two Homologous Cytochromes b₅ in a Single Cell

1983 • 95 citations

Models for the complexes formed between cytochrome b5 and the subunits of methemoglobin.

1983 • 92 citations

The Stoichiometry of the Cytochrome P-450-catalyzed Metabolism of Methoxyflurane and Benzphetamine in the Presence and Absence of Cytochrome b5

1995 • 90 citations

A model system for studying membrane biogenesis: overexpression of cytochrome B5 in yeast results in marked proliferation of the intracellular membrane*

1993 • 90 citations

Characterization of the interaction of amphipathic cytochrome b5 with stearyl coenzyme A desaturase and NADPH:cytochrome P-450 reductase.

1980 • 90 citations

The role of cytochrome b5 in adrenal microsomal steroidogenesis

1992 • 89 citations

CONGENITAL METHEMOGLOBINEMIA. A CLINICAL AND BIOCHEMICAL STUDY OF A CASE 1

1949 • 88 citations

Rat liver microsomal elongation of fatty acids. Possible involvement of cytochrome b5.

1979 • 88 citations

On the mechanism of action of cytochrome P-450. Oxidation and reduction of the ferrous dioxygen complex of liver microsomal cytochrome P-450 by cytochrome b5.

1984 • 86 citations

Hydroxylation of prostaglandins by inducible isozymes of rabbit liver microsomal cytochrome P-450. Participation of cytochrome b5.

1982 • 86 citations

Electrostatic analysis of the interaction of cytochrome c with native and dimethyl ester heme-substituted cytochrome b5

1986 • 84 citations

Mapping electrostatic interactions in macromolecular associations

1991 • 83 citations

The structure of ferrocytochrome b5 at 2.8 A resolution

1975 • 82 citations

Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase.

1981 • 81 citations

The Enzymes of Biological Membranes

1976 • 81 citations

Structural and functional properties of the membrane binding segment of cytochrome b5.

1978 • 76 citations

The membrane-embedded segment of cytochrome b5 as studied by cross-linking with photoactivatable phospholipids. II. The nontransferable form.

1983 • 75 citations

The role of cytochrome b5 in Δ12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.)

1991 • 75 citations

The membrane-embedded segment of cytochrome b5 as studied by cross-linking with photoactivatable phospholipids.

1983 • 74 citations

Cytochrome P-450 Reductase and Cytochrome b5 in Cytochrome P-450 Catalysis

1986 • 73 citations

Nomenclature of initiation, elongation and termination factors for translation in eukaryotes

1989 • 71 citations

Benzene Metabolism by Reconstituted Cytochromes P450 2B1 and 2E1 and Its Modulation by Cytochrome b5, Microsomal Epoxide Hydrolase, and Glutathione Transferases: Evidence for an Important Role of Microsomal Epoxide Hydrolase in the Formation of Hydroquinone

1993 • 71 citations

A splicing mutation in the cytochrome b5 gene from a patient with congenital methemoglobinemia and pseudohermaphrodism

1994 • 68 citations

Gene synthesis, bacterial expression and proton NMR spectroscopic studies of the rat outer mitochondrial membrane cytochrome b5

1992 • 66 citations

Orientation of the carboxyl and NH2 termini of the membrane-binding segment of cytochrome b5 on the same side of phospholipid bilayers.

1981 • 63 citations

Androgen Formation by Cytochrome P450 CYP17. Solvent Isotope Effect and pL Studies Suggest a Role for Protons in the Regulation of Oxene versus Peroxide Chemistry

1994 • 62 citations

Biosynthesis of N-glycolylneuraminic acid-containing glycoconjugates. Purification and characterization of the key enzyme of the cytidine monophospho-N-acetylneuraminic acid hydroxylation system.

1994 • 59 citations

NADH‐cytochrome b₅ reductase and cytochrome b₅ isoforms as models for the study of post‐translational targeting to the endoplasmic reticulum

1993 • 55 citations

Fluorescence study of a mutant cytochrome b5 with a single tryptophan in the membrane-binding domain

1991 • 53 citations

The identification of the heat-stable microsomal protein required for methoxyflurane metabolism as cytochrome b5.

1984 • 49 citations

Exchange of cytochrome b5 between phospholipid vesicles.

1977 • 49 citations

Identification of endogenous 1-O-alk-1'-enyl-2-acyl-sn-glycerol in myocardium and its effective utilization by choline phosphotransferase.

1988 • 49 citations

Expression of cytochrome b5 in yeast and characterization of mutants of the membrane-anchoring domain.

1992 • 48 citations

THE CYTOCHROME SYSTEM IN THE CECROPIA SILKWORM, WITH SPECIAL REFERENCE TO THE PROPERTIES OF A NEW COMPONENT

1950 • 47 citations

Evidence of binary complex formations between cytochrome P-450, cytochrome b5, and NADPH-cytochrome P-450 reductase of hepatic microsomes

1986 • 47 citations

Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase

1993 • 45 citations

The Carboxyl Terminus of the Membrane-binding Domain of Cytochrome b5 Spans the Bilayer of the Endoplasmic Reticulum

1995 • 44 citations

High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens.

1993 • 43 citations

Different Modes of Membrane Interactions of the Signal Sequence of Carp Preproinsulin and of the Insertion Sequence of Rabbit Cytochrome b₅

1982 • 41 citations

Bacterial synthesis of active rat stearyl-CoA desaturase lacking the 26-residue amino-terminal amino acid sequence.

1988 • 41 citations

Intracomplex electron transfer between ruthenium-65-cytochrome b5 and position-82 variants of yeast iso-1-cytochrome c

1993 • 40 citations

Electrostatic stabilization in four‐helix bundle proteins

1993 • 40 citations

Cytochrome P-450 isozymes involved in the oxidative metabolism of delta 9-tetrahydrocannabinol by liver microsomes of adult female rats.

1992 • 40 citations

Characterization of the covalent cross-links of the active sites of amidinated cytochrome b5 and NADH:cytochrome b5 reductase.

1990 • 40 citations

Crosslinking of cytochrome c and cytochrome b₅ with a water‐soluble carbodiimide

1989 • 39 citations

2 Fatty Acid Desaturation

1983 • 39 citations

Topography of the C terminus of cytochrome b5 tightly bound to dimyristoylphosphatidylcholine vesicles.

1987 • 38 citations

The human liver and reticulocyte cytochrome b5 mRNAs are products from a single gene

1991 • 37 citations

Evidence for participation of cytochrome b5 in microsomal Δ-6 desaturation of fatty acids

1977 • 37 citations

Computer analysis of DNA and protein sequences

1991 • 36 citations

Purification and Characterization of Cytochrome b5-like Hemoprotein Associated with Outer Mitochondrial Membrane of Rat Liver

1973 • 35 citations

Total enzymic synthesis of cholesterol from 4,4,14 alpha-trimethyl-5 alpha-cholesta-8,24-dien-3 beta-ol. Solubilization, resolution, and reconstitution of delta 7-sterol 5-desaturase.

1982 • 35 citations

Characterization of lysyl residues of NADH-cytochrome b5 reductase implicated in charge-pairing with active-site carboxyl residues of cytochrome b5 by site-directed mutagenesis of an expression vector for the flavoprotein.

1992 • 33 citations

Effects of hemolysate concentration, ionic strength and cytochrome b5 concentration on the rate of methemoglobin reduction in hemolysates of human erythrocytes

1978 • 32 citations

Cytochrome b5 and its physiological significance

1978 • 30 citations

Site of participation of cytochrome b5 in hepatic microsomal fatty acid chain elongation. Electron input in the first reduction step.

1983 • 29 citations

Obligatory role of cytochrome b5 in the microsomal metabolism of methoxyflurane

1985 • 28 citations

The Photosynthetic Reaction Centre from the Purple Bacterium Rhodopseudomonas viridis

2004 • 28 citations

In‐vitro evidence for the regulation of 17,20‐lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome

1994 • 27 citations

Essential Role of His163 of Cytochrome P450 1A2 in Catalytic Functions Associated with Cytochrome b5

1994 • 26 citations

The Function of Tyrosine 74 of Cytochrome b5

1993 • 24 citations

The role of COOH-terminal anionic residues in binding cytochrome b5 to phospholipid vesicles and biological membranes.

1981 • 23 citations

Immunocytochemical localization of alkane-inducible cytochrome P-450 and its NADPH-dependent reductase in the yeast Candida maltosa.

1992 • 22 citations

Isolation and partial characterization of the NH2-terminal membrane-binding domain of NADH-cytochrome b5 reductase.

1983 • 21 citations

?5 Desaturase activity in rat kidney microsomes

1993 • 21 citations

Cytochrome b5 and Cytochrome b5 Reductase from a Chemical and X-Ray Diffraction Viewpoint

1985 • 20 citations

High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens

1993 • 18 citations

Palmitoyl‐CoA Elongation in Brain Microsomes: Dependence on Cytochrome b₅ and NADH‐Cytochrome b₅ Reductase

1985 • 16 citations

Partial Purification and Characterization of Lathosterol 5-Desaturase from Rat Liver Microsomes1

1985 • 14 citations

Kinetics of the Reduction of Cytochrome b5 with Mutations in Its Membrane-Binding Domain

1994 • 13 citations

Molecular cloning of rabbit cytochrome b5 genes: Evidence for the occurrence of two separate genes encoding the soluble and microsomal forms

1992 • 9 citations

Evidence against cytochrome b5 involvement in liver microsomal fatty acid elongation

1991 • 7 citations

Fatty acid desaturation in an animal cell mutant defective in plasmanylethanolamine desaturase

1994 • 7 citations

Deleted Work

1955 • 0 citations