Biodiversity of the P450 catalytic cycle: yeast cytochrome b₅/NADH cytochrome b₅ reductase complex efficiently drives the entire sterol 14‐demethylation (CYP51) reaction

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

Purification and Properties of Rat Liver Microsomal Stearyl Coenzyme A Desaturase

1974 • 471 citations

Separate roles for FMN and FAD in catalysis by liver microsomal NADPH-cytochrome P-450 reductase.

1981 • 295 citations

Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis

1989 • 261 citations

The Role of Cytochrome b5 in the Biosynthesis of Androgens by Human P450c17

1995 • 224 citations

Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system.

1980 • 224 citations

Characterization and catalytic properties of the sterol 14α-demethylase from Mycobacterium tuberculosis

1999 • 216 citations

The Mutation T315A in Candida albicans Sterol 14α-Demethylase Causes Reduced Enzyme Activity and Fluconazole Resistance through Reduced Affinity

1997 • 200 citations

Identification of an epitope on the P and V proteins of simian virus 5 that distinguishes between two isolates with different biological characteristics

1991 • 196 citations

A cytochromeb₅is required for full activity of flavonoid 3′,5′-hydroxylase, a cytochrome P450 involved in the formation of blue flower colors

1999 • 168 citations

Mechanism of C-5 double bond introduction in the biosynthesis of cholesterol by rat liver microsomes.

1977 • 164 citations

Modulation of the activity of human 17 α-hydroxylase-17,20-lyase (CYP17) by cytochrome b5: endocrinological and mechanistic implications

1995 • 146 citations

The Mechanism of the Acyl-Carbon Bond Cleavage Reaction Catalyzed by Recombinant Sterol 14α-Demethylase of Candida albicans (Other Names Are: Lanosterol 14α-Demethylase, P-45014DM, and CYP51)

1996 • 142 citations

Characterization of Saccharomyces cerevisiae CYP61, Sterol Δ22-Desaturase, and Inhibition by Azole Antifungal Agents

1997 • 139 citations

Cytochrome P450 of Fungi: Primary Target for Azole Antifungal Agents

1988 • 136 citations

Studies on the association of cytochrome P-450 and NADPH-cytochrome c reductase during catalysis in a reconstituted hydroxylating system.

1979 • 135 citations

The metabolism of methylated aminoazo dyes. VI. Intracellular distribution and properties of the demethylase system.

1957 • 121 citations

The sporulation-specific enzymes encoded by the DIT1 and DIT2 genes catalyze a two-step reaction leading to a soluble LL-dityrosine-containing precursor of the yeast spore wall.

1994 • 119 citations

Studies on three microsomal electron transfer enzyme systems

1977 • 92 citations

Effects of cytochrome b5 on cytochrome P-450-catalyzed reactions. Studies with manganese-substituted cytochrome b5.

1984 • 91 citations

Immunochemical evidence for the participation of cytochrome b5 in the NADH synergism of the NADPH-dependent mono-oxidase system of hepatic microsomes

1974 • 77 citations

Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain

1994 • 77 citations

Purification and reconstitution of activity of Saccharomyces cerevisiae P450 61, a sterol Δ²²‐desaturase

1995 • 71 citations

Association of cytochrome b5 and cytochrome P-450 reductase with cytochrome P-450 in the membrane of reconstituted vesicles.

1982 • 64 citations

Microsomal Electron Transfer in Higher Plants: Cloning and Heterologous Expression of NADH-Cytochromeb5Reductase from Arabidopsis

1999 • 63 citations

Disruption of the Saccharomyces Cerevlsiae gene for NADPH-cytochrome P450 reductase causes increased sensitivity to ketoconazole

1989 • 63 citations

The N-Terminal Membrane Domain of Yeast NADPH-Cytochrome P450 (CYP) Oxidoreductase Is Not Required for Catalytic Activity in Sterol Biosynthesis or in Reconstitution of CYP Activity

1998 • 57 citations

The Effects of Cytochrome b5, NADPH-P450 Reductase, and Lipid on the Rate of 6β-Hydroxylation of Testosterone as Catalyzed by a Human P450 3A4 Fusion Protein

1995 • 54 citations

The obligatory requirement of cytochrome 5 in the -nitroanisole O-demethylation reaction catalyzed by cytochrome P-450 with a high affinity for cytochrome 5

1979 • 53 citations

Inhibition of transcription factor binding to the HER2 promoter by triplex-forming oligodeoxyribonucleotides

1994 • 47 citations

The Properties of Nucleotide Complexes with Microsomal Cytochrome Reductase

1959 • 39 citations

Sterol 22‐desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism

1997 • 39 citations

Ca2+ Binding to the First Epidermal Growth Factor Module of Coagulation Factor VIIa Is Important for Cofactor Interaction and Proteolytic Function

1997 • 33 citations

Involvement of cytochrome b5 and a cyanide-sensitive monooxygenase in the 4-demethylation of 4,4-dimethyl-zymosterol by yeast microsomes

1981 • 32 citations

Purification and properties of plant cytochrome b5

1985 • 24 citations