Anxiolytic actions of the substance P (NK1) receptor antagonist L-760735 and the 5-HT1A agonist 8-OH-DPAT in the social interaction test in gerbils

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The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs

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Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms ¹

1990 • 449 citations

Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists

1999 • 282 citations

Comparative Study of Pre- and Postsynaptic 5-HT_1AReceptor Modulation of Anxiety in Two Ethological Animal Tests

1996 • 229 citations

Investigation into species variants in tachykinin NK₁ receptors by use of the non‐peptide antagonist, CP‐96,345

1991 • 224 citations

Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphé nucleus of the rat

1988 • 186 citations

Bimodal modulation by nicotine of anxiety in the social interaction test: Role of the dorsal hippocampus.

1998 • 182 citations

Pharmacological blockade or genetic deletion of substance P (NK1) receptors attenuates neonatal vocalisation in guinea-pigs and mice

2000 • 171 citations

Acute and Chronic Effects of Gepirone and Fluoxetine in Rats Tested in the Elevated Plus-maze

2000 • 169 citations

Bimodal modulation by nicotine of anxiety in the social interaction test: Role of the dorsal hippocampus.

1998 • 165 citations

Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice

1996 • 164 citations

The dorsal raphé nucleus is a crucial structure mediating nicotine's anxiolytic effects and the development of tolerance and withdrawal responses

2001 • 112 citations

Anxiolytic Action of a Neurokinin1 Receptor Antagonist in the Social Interaction Test

1997 • 112 citations

Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: New tools for investigating neurokinin function

1991 • 109 citations

Serotonin and substance P co-exist in dorsal raphe neurons of the human brain

1999 • 96 citations

Substance P induces a cardiovascular defense reaction in the rat: pharmacological characterization.

1988 • 90 citations

Effects of sequential removal of rats from a group cage, and of individual housing of rats, on substance P, cholecystokinin and somatostatin levels in the periaqueductal grey and limbic regions

1994 • 88 citations

Phylogeny of tachykinin receptor localization in the vertebrate central nervous system: apparent absence of neurokinin-2 and neurokinin-3 binding sites in the human brain

1991 • 86 citations

Substance P is involved in the sensitization of the acoustic startle response by footshocks in rats

1994 • 82 citations

The NK1-receptor antagonist NKP608 has an antidepressant-like effect in the chronic mild stress model of depression in rats

2000 • 82 citations

Chemoarchitecture of the primate dorsal raphe nucleus

1998 • 80 citations

Differential inhibition of foot tapping and chromodacryorrhoea in gerbils by CNS penetrant and non-penetrant tachykinin NK1 receptor antagonists

1994 • 76 citations

The substance P antagonist L-760,735 inhibits stress-induced NK1 receptor internalisation in the basolateral amygdala

1999 • 73 citations

NKP608, an NK1 receptor antagonist, has an anxiolytic action in the social interaction test in rats

2000 • 73 citations

Chronic Fluoxetine in Tests of Anxiety in Rat Lines Selectively Bred for Differential 5-HT1A Receptor Function

1999 • 68 citations

Inhibition of shock-induced foot tapping behaviour in the gerbil by a tachykinin NK1 receptor antagonist

2001 • 57 citations

NKP608: a selective NK-1 receptor antagonist with anxiolytic-like effects in the social interaction and social exploration test in rats

2000 • 55 citations

Effects of substance P and neurokinin A (substance K) on motor behavior: unique effect of substance P attributable to its amino-terminal sequence

1987 • 53 citations

Roles of 5-HT1A receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-OH-DPAT and S 15535 in a modified Geller–Seifter conflict model

2000 • 46 citations

Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action

2001 • 43 citations

Substance P as an Immune Modulator of Anxiety

1997 • 39 citations

Behavioural effects in gerbils of the 5-HT3 receptor antagonists, BRL 43694 and ICS 205-930, under circumstances of high and low light intensity

1990 • 25 citations

Dizocilpine does not prevent the development of tolerance to the anxiolytic effects of diazepam in rats

1999 • 25 citations

Diagnosis and Management of Generalized Anxiety Disorder

1999 • 19 citations

“Neuropeptides 2000”

2000 • 1 citations